The Healing Analysis of II Degree Burn from Surgery Essential Oil Ointment (Curcuma Longa) in Wistar Rats (Rattus Norvegicus)

Data in Indonesia the death rate from burns is still high at around 40%, mainly caused by severe burns. The most potential medicinal turmeric plant is its rhizome, which contains the phenolic compound curcumin and essential oils. Some of the benefits of turmeric antioxidants, anti-inflammatory, anti-cancer, acetylcholinesterase activity inhibitors, anti-fungal, and anti-bacterial. This study aims to find out the phytochemical content and effects of Turmeric Essential Oil Ointment (Curcuma longa Linn) in curing grade II burns in Wistar rats (Rattus norvegicus). This type of research is experimental with a pre-post approach and post-test control group design. The study was conducted at Riwandi Pet Shop and Animal House March-May 2021. The research sample is turmeric (Curcuma longa) obtained from a traditional market in the city of Medan and identified in herbarium Medanese (MEDA), Laboratoirum Taxonomy of Plants, Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), University of North Sumatra, Medan. The test animal is a Wistar strain rat with as many as 20 tails divided into 4 treatment groups, so each group consists of 5 rats. The results of the study contained significant differences in the epithelial period of the standard group, 10% turmeric ointment and 15% against the control group. However, in the turmeric ointment group and the standard group, there was no difference in epithelialization periods. This is evident from the value P < 0.05 (Value P = 0.029). The healing effects of burns possessed by Turmeric ointment are both 10% and 15% and nebacetin ointment as standard shows significant differences. Where the wound contraction rate of turmeric ointment is 15% better than nebacetin ointment as standard. But in both turmeric ointments, both 10% and 15% and nebacetin ointment as standard did not show significant differences in the parameters of the epithelial period.

[1]  B. Razavi,et al.  A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents , 2021, Phytotherapy research : PTR.

[2]  Ashilah Mumtaz Hakim.  Efektifitas Aloe vera terhadap Luka Bakar , 2020 .

[3]  Lia Fikayuniar,et al.  UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma longa L.) TERHADAP Staphylococcus aureus DAN Pseudomonas aeruginosa , 2019, Pharma Xplore : Jurnal Ilmiah Farmasi.

[4]  F. Carmona,et al.  Curcuma longa L. ameliorates asthma control in children and adolescents: A randomized, double-blind, controlled trial. , 2019, Journal of ethnopharmacology.

[5]  Muthia Milasari,et al.  PENGARUH PEMBERIAN SALEP EKSTRAK KUNYIT KUNING (Curcuma longa Linn) TERHADAP PENYEMBUHAN LUKA SAYAT PADA TIKUS PUTIH (Rattus norvegicus) , 2019, Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan.

[6]  A. Adedapo,et al.  Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs , 2018, Scientific Reports.

[7]  N. Muhajir,et al.  Daya Hambat Minyak Atsiri Rimpang Kunyit terhadap Pertumbuhan Candida Albicans In Vitro , 2018 .

[8]  Anastasia Setyopuspito Pramitaningastuti,et al.  UJI EFEKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN SRIKAYA (Annona squamosa. L) TERHADAP UDEMA KAKI TIKUS PUTIH JANTAN GALUR WISTAR , 2017 .

[9]  Nurul Khumaida,et al.  Keragaman Beberapa Aksesi Temu Hitam (Curcuma aeruginosa Roxb.) Berdasarkan Karakter Morfologi , 2017 .

[10]  N. Sanlier,et al.  Curcumin, an active component of turmeric (Curcuma longa), and its effects on health , 2017, Critical reviews in food science and nutrition.

[11]  M. Ludong,et al.  PENGARUH KONSENTRASI ETANOL TERHADAP KARAKTERISTIK EKSTRAK PEWARNA ALAMI BUAH MERAH (Pandanus conoideus Lamk.) DAN APLIKASINYA PADA PRODUK PANGAN , 2016 .

[12]  F. Edelmann,et al.  Metal Complexes of Curcumin — Synthetic Strategies, Structures and Medicinal Applications , 2015 .

[13]  Dewi Anggraini,et al.  PROFIL PENDERITA ULKUS DEKUBITUS YANG MENJALANI TIRAH BARING DI RUANG RAWAT INAP RSUD ARIFIN ACHMAD PROVINSI RIAU PERIODE JANUARI 2011-DESEMBER 2013 , 2015 .

[14]  D. Fitriani.  PENGARUH EKSTRAK KUNYIT TERHADAP PENINGKATAN JUMLAH MAKROFAG PADA SOKET PASCA PENCABUTAN GIGI Cavia cobaya , 2015 .

[15]  Safwan Safwan,et al.  UJI AKTIVITAS MINYAK ATSIRI RIMPANG KUNYIT (Curcuma Longa Linn) PADA TIKUS SPRAGUE DAWLEY MODEL DEMENSIA (Kajian Penghambat Aktivitas Asetilkolinesterase) , 2014 .

[16]  W. Chrzanowski,et al.  Curcumin as a wound healing agent. , 2014, Life sciences.

[17]  K. Zandi,et al.  A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin , 2014, BioMed research international.

[18]  Fatima Zohra Rahmani,et al.  Curcuma longa L. , 2013 .

[19]  J. Negi,et al.  Major Constituents, Antioxidant and Antibacterial Activities of Zanthoxylum armatum DC. Essential Oil , 2012 .

[20]  D. Nayak,et al.  Areca catechu: Effect of topical ethanolic extract on burn wound healing in albino rats , 2012 .

[21]  Tutik Rahayu.  PENATALAKSANAAN LUKA BAKAR (COMBUSTIO) , 2012 .

[22]  S. Sandhu,et al.  Practices in Wound Healing Studies of Plants , 2011, Evidence-based complementary and alternative medicine : eCAM.

[23]  L. Leibovici,et al.  Prophylactic antibiotics for burns patients: systematic review and meta-analysis , 2010, BMJ : British Medical Journal.

[24]  K. Lee,et al.  Recent advances in the investigation of curcuminoids , 2008, Chinese medicine.

[25]  S. J. Phillips,et al.  Physiology of wound healing and surgical wound care. , 2000, ASAIO journal.

[26]  C Torrance,et al.  The physiology of wound healing. , 1986, Nursing.

[27]  Gusti Revilla,et al.  Pengaruh Papain Getah Pepaya Terhadap Pembentukan Jaringan Granulasi pada Penyembuhan Luka Bakar Tikus Percobaan , 2014 .

[28]  V. Sabale,et al.  Curcuma longa Linn. A Phytochemical and Phytopharmacological Review , 2013 .