Analysis of ventricular fibrillation signals using feature selection methods

Feature selection methods in machine learning models are a powerful tool to knowledge extraction. In this work they are used to analyse the intrinsic modifications of cardiac response during ventricular fibrillation due to physical exercise. The data used are two sets of registers from isolated rabbit hearts: control (G1: without physical training), and trained (G2). Four parameters were extracted (dominant frequency, normalized energy, regularity index and number of occurrences). From them, 18 features were extracted. This work analyses the relevance of each feature to classify the records in G1 and G2 using Logistic Regression, Multilayer Perceptron and Extreme Learning Machine. Three feature selection methods are presented: one based on the output variation, other on the classification results and, finally, another method based in the variation in ROC curve. Although we obtained different sorting of features for each used classifier, the features related to the mean value and standard deviation of dominant frequency and regularity index were the most relevant, stating that the modifications in VF response produced by physical exercise are related to the cardiac activation rate, as to the regularity of that activation.

[1]  S. Harrison,et al.  Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes , 2002, The Journal of physiology.

[2]  G. Billman,et al.  Effect of carbachol and cyclic GMP on susceptibility to ventricular fibrillation , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  R Bolognesi,et al.  Cardiovascular adaptations to physical exercise. , 2000, Italian heart journal : official journal of the Italian Federation of Cardiology.

[4]  Luca Faes,et al.  A method for quantifying atrial fibrillation organization based on wave-morphology similarity , 2002, IEEE Transactions on Biomedical Engineering.

[5]  Gustavo Camps-Valls,et al.  Unbiased sensitivity analysis and pruning techniques in neural networks for surface ozone modelling , 2005 .

[6]  Antonio J. Serrano,et al.  Feature selection using ROC curves on classification problems , 2010, The 2010 International Joint Conference on Neural Networks (IJCNN).

[7]  Trevor Hastie,et al.  The Elements of Statistical Learning , 2001 .

[8]  Simon Haykin,et al.  Neural Networks and Learning Machines , 2010 .

[9]  Kumaraswamy Nanthakumar,et al.  Effect of global ischemia and reperfusion during ventricular fibrillation in myopathic human hearts. , 2009, American journal of physiology. Heart and circulatory physiology.

[10]  Chee Kheong Siew,et al.  Extreme learning machine: Theory and applications , 2006, Neurocomputing.

[11]  Eric R. Ziegel,et al.  The Elements of Statistical Learning , 2003, Technometrics.

[12]  G. Calcagnini,et al.  Descriptors of wavefront propagation , 2006, IEEE Engineering in Medicine and Biology Magazine.

[13]  L. Faes,et al.  A morphology-based approach to the evaluation of atrial fibrillation organization , 2007, IEEE Engineering in Medicine and Biology Magazine.

[14]  Guy Salama,et al.  Life Span of Ventricular Fibrillation Frequencies , 2002, Circulation research.

[15]  Juan Francisco Guerrero Martínez,et al.  Análisis de regularidad en fibrilación ventricular: aplicación a registros de mapeado cardíaco , 2008 .

[16]  Matthias Schroder,et al.  Logistic Regression: A Self-Learning Text , 2003 .