Anticipatory brain activity predicts the success or failure of subsequent emotion regulation.

Expectations about an upcoming emotional event have the power to shape one's subsequent affective response for better or worse. Here, we used mediation analyses to examine the relationship between brain activity when anticipating the need to cognitively reappraise aversive images, amygdala responses to those images and subsequent success in diminishing negative affect. We found that anticipatory activity in right rostrolateral prefrontal cortex was associated with greater subsequent left amygdala responses to aversive images and decreased regulation success. In contrast, anticipatory ventral anterior insula activity was associated with reduced amygdala responses and greater reappraisal success. In both cases, left amygdala responses mediated the relationship between anticipatory activity and reappraisal success. These results suggest that anticipation facilitates successful reappraisal via reduced anticipatory prefrontal 'cognitive' elaboration and better integration of affective information in paralimbic and subcortical systems.

[1]  W. Mischel,et al.  Cognitive appraisals and transformations in delay behavior. , 1975 .

[2]  M. Mesulam,et al.  Insula of the old world monkey. III: Efferent cortical output and comments on function , 1982, The Journal of comparative neurology.

[3]  M. Mesulam,et al.  Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain , 1982, The Journal of comparative neurology.

[4]  M. Mesulam,et al.  Insula of the old world monkey. II: Afferent cortical input and comments on the claustrum , 1982, The Journal of comparative neurology.

[5]  M. Gazzaniga.  Handbook of Cognitive Neuroscience , 1984, Springer US.

[6]  M M Mesulam,et al.  Thalamic connections of the insula in the rhesus monkey and comments on the paralimbic connectivity of the medial pulvinar nucleus , 1984, The Journal of comparative neurology.

[7]  D. A. Kenny,et al.  The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. , 1986, Journal of personality and social psychology.

[8]  Timothy D. Wilson,et al.  Preferences as expectation-driven inferences: effects of affective expectations on affective experience. , 1989, Journal of personality and social psychology.

[9]  K Merikangas,et al.  Fear-potentiated startle in humans: effects of anticipatory anxiety on the acoustic blink reflex. , 1991, Psychophysiology.

[10]  M. Bradley,et al.  Looking at pictures: affective, facial, visceral, and behavioral reactions. , 1993, Psychophysiology.

[11]  L. F. Barrett,et al.  Handbook of Emotions , 1993 .

[12]  Timothy D. Wilson,et al.  THE ROLE OF AFFECTIVE EXPECTATIONS IN SUBJECTIVE EXPERIENCE AND DECISION-MAKING , 1994 .

[13]  J. R. Augustine.  Circuitry and functional aspects of the insular lobe in primates including humans , 1996, Brain Research Reviews.

[14]  J. Gross.  The Emerging Field of Emotion Regulation: An Integrative Review , 1998 .

[15]  J. Gabrieli,et al.  The frontopolar cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex , 2000, Psychobiology.

[16]  M. Honda,et al.  Expectation of Pain Enhances Responses to Nonpainful Somatosensory Stimulation in the Anterior Cingulate Cortex and Parietal Operculum/Posterior Insula: an Event-Related Functional Magnetic Resonance Imaging Study , 2000, The Journal of Neuroscience.

[17]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[18]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[19]  M. Corbetta,et al.  Separating Processes within a Trial in Event-Related Functional MRI II. Analysis , 2001, NeuroImage.

[20]  N. Epley,et al.  Do others judge us as harshly as we think? Overestimating the impact of our failures, shortcomings, and mishaps. , 2001, Journal of personality and social psychology.

[21]  James K. Kroger,et al.  Rostrolateral Prefrontal Cortex Involvement in Relational Integration during Reasoning , 2001, NeuroImage.

[22]  G. Shulman,et al.  Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  L. F. Barrett,et al.  Knowing what you're feeling and knowing what to do about it: Mapping the relation between emotion differentiation and emotion regulation , 2001 .

[24]  J. Gabrieli,et al.  Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion , 2002, Journal of Cognitive Neuroscience.

[25]  Y. Okamoto,et al.  Brain activity during expectancy of emotional stimuli: an fMRI study , 2003, Neuroreport.

[26]  S. Scott,et al.  The role of the rostral frontal cortex (area 10) in prospective memory: a lateral versus medial dissociation , 2003, Neuropsychologia.

[27]  H. Critchley,et al.  Neural systems supporting interoceptive awareness , 2004, Nature Neuroscience.

[28]  Kevin N. Ochsner,et al.  For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion , 2004, NeuroImage.

[29]  Tor D Wager,et al.  Neuroimaging studies of shifting attention: a meta-analysis , 2004, NeuroImage.

[30]  K. Phan,et al.  Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging study , 2005, Biological Psychiatry.

[31]  Raymond J. Dolan,et al.  Anxiety Reduction through Detachment: Subjective, Physiological, and Neural Effects , 2005, Journal of Cognitive Neuroscience.

[32]  Matthew C. Keller,et al.  Increased sensitivity in neuroimaging analyses using robust regression , 2005, NeuroImage.

[33]  A. Mathews,et al.  Anticipatory anxiety and risk perception , 1987, Cognitive Therapy and Research.

[34]  Jeffrey C. Cooper,et al.  Individual differences in trait rumination and the neural systems supporting cognitive reappraisal , 2005, Cognitive, affective & behavioral neuroscience.

[35]  J. Gross,et al.  The cognitive control of emotion , 2005, Trends in Cognitive Sciences.

[36]  Stephen Lawrie,et al.  Functional Specialization within Rostral Prefrontal Cortex (Area 10): A Meta-analysis , 2006, Journal of Cognitive Neuroscience.

[37]  C. Frith,et al.  Meeting of minds: the medial frontal cortex and social cognition , 2006, Nature Reviews Neuroscience.

[38]  Richard J. Davidson,et al.  Functional neuroanatomy of aversion and its anticipation , 2006, NeuroImage.

[39]  Henrik Walter,et al.  Cognitive modulation of emotion anticipation , 2006, The European journal of neuroscience.

[40]  Georg Northoff,et al.  Self-referential processing in our brain—A meta-analysis of imaging studies on the self , 2006, NeuroImage.

[41]  Raymond J. Dolan,et al.  Neural Correlates of Self-distraction from Anxiety and a Process Model of Cognitive Emotion Regulation , 2006, Journal of Cognitive Neuroscience.

[42]  Richard J. Davidson,et al.  Gaze fixations predict brain activation during the voluntary regulation of picture-induced negative affect , 2007, NeuroImage.

[43]  Lutz Jäncke,et al.  Modulation of anticipatory emotion and perception processing by cognitive control , 2007, NeuroImage.

[44]  J. Jonides,et al.  Interference resolution: Insights from a meta-analysis of neuroimaging tasks , 2007, Cognitive, affective & behavioral neuroscience.

[45]  B. Abler,et al.  Anticipation of aversive stimuli activates extended amygdala in unipolar depression. , 2007, Journal of psychiatric research.

[46]  Scott T. Grafton,et al.  Wandering Minds: The Default Network and Stimulus-Independent Thought , 2007, Science.

[47]  Henrik Walter,et al.  Expecting unpleasant stimuli – An fMRI study , 2007, Psychiatry Research: Neuroimaging.

[48]  Lutz Jäncke,et al.  Neural correlates of a ‘pessimistic’ attitude when anticipating events of unknown emotional valence , 2007, NeuroImage.

[49]  J. Gross,et al.  The Neural Bases of Emotion Regulation: Reappraisal and Suppression of Negative Emotion , 2008, Biological Psychiatry.

[50]  Brent L. Hughes,et al.  Prefrontal-Subcortical Pathways Mediating Successful Emotion Regulation , 2008, Neuron.

[51]  M. Delgado,et al.  Regulating the expectation of reward via cognitive strategies , 2008, Nature Neuroscience.

[52]  Joseph E LeDoux,et al.  Neural Circuitry Underlying the Regulation of Conditioned Fear and Its Relation to Extinction , 2008, Neuron.

[53]  K. Ochsner,et al.  The role of social cognition in emotion , 2008, Trends in Cognitive Sciences.

[54]  Matthew L. Davidson,et al.  The neuroimaging of emotion. , 2008 .

[55]  Lisa Feldman Barrett,et al.  Functional grouping and cortical–subcortical interactions in emotion: A meta-analysis of neuroimaging studies , 2008, NeuroImage.

[56]  K. Christoff,et al.  Experience sampling during fMRI reveals default network and executive system contributions to mind wandering , 2009, Proceedings of the National Academy of Sciences.

[57]  Jeremy D. Schmahmann,et al.  Functional topography in the human cerebellum: A meta-analysis of neuroimaging studies , 2009, NeuroImage.

[58]  Martin A. Lindquist,et al.  Brain mediators of cardiovascular responses to social threat, Part II: Prefrontal-subcortical pathways and relationship with anxiety , 2009, NeuroImage.

[59]  Kevin N. Ochsner,et al.  Neural Systems Supporting the Control of Affective and Cognitive Conflicts , 2009, Journal of Cognitive Neuroscience.

[60]  F. Van Overwalle.  Social cognition and the brain: A meta‐analysis , 2009, Human brain mapping.

[61]  John D E Gabrieli,et al.  Bottom-Up and Top-Down Processes in Emotion Generation , 2009, Psychological science.

[62]  A. Craig,et al.  How do you feel — now? The anterior insula and human awareness , 2009, Nature Reviews Neuroscience.

[63]  N. Bolger,et al.  Brain Mediators of Predictive Cue Effects on Perceived Pain , 2010, The Journal of Neuroscience.

[64]  Negative bias of processing ambiguously cued emotional stimuli , 2010, Neuroreport.

[65]  D. Gilbert,et al.  A Wandering Mind Is an Unhappy Mind , 2010, Science.

[66]  A. Aleman,et al.  Self-reflection and the brain: A theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia , 2010, Neuroscience & Biobehavioral Reviews.

[67]  Kevin N. Ochsner,et al.  The Neural Bases of Distraction and Reappraisal , 2010, Journal of Cognitive Neuroscience.

[68]  Raffael Kalisch,et al.  A meta-analysis of instructed fear studies: Implications for conscious appraisal of threat , 2010, NeuroImage.

[69]  A. Kring,et al.  Emotion regulation and psychopathology : a transdiagnostic approach to etiology and treatment , 2010 .

[70]  Tor D Wager,et al.  Predicting Individual Differences in Placebo Analgesia: Contributions of Brain Activity during Anticipation and Pain Experience , 2011, The Journal of Neuroscience.

[71]  Frank Van Overwalle,et al.  A dissociation between social mentalizing and general reasoning , 2011, NeuroImage.

[72]  Naomi B. Pitskel,et al.  Three Systems of Insular Functional Connectivity Identified with Cluster Analysis , 2010, Cerebral cortex.

[73]  Georg Northoff,et al.  How is our self related to midline regions and the default-mode network? , 2011, NeuroImage.

[74]  Mauricio R. Delgado,et al.  The Influence of Emotion Regulation on Decision-making under Risk , 2011, Journal of Cognitive Neuroscience.

[75]  Joshua M. Carlson,et al.  Feeling anxious: anticipatory amygdalo-insular response predicts the feeling of anxious anticipation. , 2011, Social cognitive and affective neuroscience.

[76]  C. Caltagirone,et al.  Keeping memory for intentions: a cTBS investigation of the frontopolar cortex. , 2011, Cerebral cortex.

[77]  Jamil Zaki,et al.  Overlapping activity in anterior insula during interoception and emotional experience , 2012, NeuroImage.

[78]  Kevin N. Ochsner,et al.  A Meta-analysis of Functional Neuroimaging Studies of Self- and Other Judgments Reveals a Spatial Gradient for Mentalizing in Medial Prefrontal Cortex , 2012, Journal of Cognitive Neuroscience.

[79]  Jennifer A. Silvers,et al.  Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies. , 2014, Cerebral cortex.