A comparison of the incidence of pruritus following epidural opioid administration in the parturient

Epidural morphine is associated with a high incidence of pruritus when used for pain control in the post-Caesarean section population. The purpose of this study was to compare the incidence of pruritus associated with epidural morphine, fentanyl, buprenorphine and butorphanol. Sixty healthy Caesarean section patients were studied in a double-blind randomized fashion. Patients were questioned at 1, 3, 12 and 24 hours postpartum for the incidence of pruritus. This study demonstrated that the incidence of pruritus was significantly higher following the use of epidural morphine and fentanyl. Even though epidural butorphanol and buprenorphine exhibited a low incidence of pruritus, their duration of analgesia was not long enough to make either attractive for singledose administration.RésuméAprès une césarienne, l’analgésie à la morphine par voie péridurale est souvent associée à du prurit. Dans une étude à double insu chez 60 patientes en santé, nous avorts comparé la morphine, le fentanyl, la buprénorphine et le butorphanol quant à l’incidence de cette complication lorsque injecté par voie péridurale lors d’une césarienne. On recherchait la présence de prurit à 1, 3, 12 et 24 h post-injection. Le problème s’est avéré plus fréquent avec la morphine et le fentanyl. Malheureusement, malgré une faible incidence de prurit, la durée de l’analgésie avec la buprénorphine ou le butorphanol était insuffisante en mode d’injection unique.

[1]  M. Douglas,et al.  Influence of bupivacaine as an adjuvant to epidural morphine for analgesia after cesarean section. , 1988 .

[2]  W. Ackerman,et al.  A COMPARISON OF EPIDURAL FENTANYL, BUPRENORPHINK AND BUTORPHANOL FOR THE MANAGEMENT OF POST CESAREAN SECTION PAIN , 1988 .

[3]  J. Chang,et al.  Increased incidence of itching and herpes simplex in patients given epidural morphine after cesarean section. , 1988, Anesthesia and analgesia.

[4]  J. Conly,et al.  Recurrent Herpes Simplex Virus Labialis and the Use of Epidural Morphine in Obstetric Patients , 1988, Anesthesia and analgesia.

[5]  S. Datta,et al.  EPIDURAL BUTORPHANOL/FENTANYL FOR POST-CESAREAN DELIVERY ANALGESIA , 1987 .

[6]  H. Turndorf,et al.  SYSTEMIC HISTAHINE RELEASE BY EPIDURAL MORPHINE , 1987 .

[7]  K. Sibert,et al.  A COMPARISON OF MEPERIDINE, MORPHINE AND OXYMORPHONE FOR USE IN PATIENT CONTROLLED ANALGESIA FOLLOWING CESAREAN DELIVERY , 1987 .

[8]  S. Datta,et al.  Epidural fentanyl for postcesarean delivery pain management. , 1985, Anesthesiology.

[9]  T. Abboud,et al.  The Effects of Naloxone Associated with the Intrathecal Use of Morphine in Labor , 1985, Anesthesia and analgesia.

[10]  E. Lanz,et al.  Epidural buprenorphine — A double-blind study of postoperative analgesia and side effects Anesth. Analg., 63 (1984) 593–598 , 1985, Pain.

[11]  C. Hunt,et al.  EPIDURAL BUTORPHANOL FOR POST-CESAREAN DELIVERY PAIN MANAGEMENT , 1984 .

[12]  E. Lanz,et al.  Epidural Buprenorphine—A Double‐Blind Study of Postoperative Analgesia and Side Effects , 1984 .

[13]  M. Rosen,et al.  Epidural Morphine Analgesia After Cesarean Delivery , 1984, Obstetrics and gynecology.

[14]  J. Villiger Binding of buprenorphine to opiate receptors Regulation by guanyl nucleotides and metal ions , 1984, Neuropharmacology.

[15]  E. T. Iwamoto,et al.  Multiple opioid receptors , 1981, Medicinal research reviews.

[16]  M. Tardieu [Acute viral meningitis and encephalitis in children]. , 1987, Pediatrie.

[17]  L. Terenius,et al.  Receptor Mechanisms for Nociception , 1986, International Anesthesiology Clinics.