Guanylpiperidine peptidomimetics: potent and selective bis-cation inhibitors of factor Xa.

[1]  Y. Cheng,et al.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. , 1973, Biochemical pharmacology.

[2]  J. Morrison,et al.  The slow-binding and slow, tight-binding inhibition of enzyme-catalysed reactions , 1982 .

[3]  H. Kunz,et al.  Diastereoselective Strecker Synthesis of α‐Aminonitriles on Carbohydrate Templates , 1987 .

[4]  R. Colman,et al.  Hemostasis and Thrombosis: Basic Principles and Clinical Practice , 1988 .

[5]  K. Mann,et al.  Cofactor proteins in the assembly and expression of blood clotting enzyme complexes. , 1988, Annual review of biochemistry.

[6]  H. Kunz,et al.  Carbohydrates as chiral templates: diastereoselective Ugi synthesis of (S)-amino acids using O-acylated D-arabinopyranosylamine as the auxiliary , 1989 .

[7]  R. Huber,et al.  Structure of human des(1-45) factor Xa at 2.2 A resolution. , 1993, Journal of molecular biology.

[8]  G. Vlasuk.  Structural and Functional Characterization of Tick Anticoagulant Peptide (TAP): A Potent and Selective Inhibitor of Blood Coagulation Factor Xa , 1993, Thrombosis and Haemostasis.

[9]  Steven H. Huang,et al.  Ancylostoma caninum anticoagulant peptide: a hookworm-derived inhibitor of human coagulation factor Xa. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Nutt,et al.  Novel and general method for the preparation of peptidyl argininals , 1996 .

[11]  R. Nutt,et al.  Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties. , 1996, Journal of medicinal chemistry.