论文信息 - Preferential formation of (2'–5')-linked internucleotide bonds in non-enzymatic reactions

Preferential formation of (2'–5')-linked internucleotide bonds in non-enzymatic reactions

Abstract The reactions of ImpU with MepU, MepC, MepA and MepG in aqueous solution yield mixtures of isomeric dinucleotides in which the (2'–5') linked compound is 6–9 times more abundant than the (3'–5')-linked compound. The ratio of isomers obtained from ImpA and MepA under these conditions is similar, but increases to 18 when a poly(U) template is included in the reaction mixture.

L. Orgel | R. Lohrmann | Leslie E. Orgel | R. Lohrmann

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