Amino acid transporters revisited: New views in health and disease.

[1]  M. Hediger,et al.  Establishment of a novel microscale thermophoresis ligand-binding assay for characterization of SLC solute carriers using oligopeptide transporter PepT1 (SLC15 family) as a model system. , 2018, Journal of pharmacological and toxicological methods.

[2]  C. Göritz,et al.  Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth , 2018, The EMBO journal.

[3]  R. Jahn,et al.  Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter. , 2018, Cell reports.

[4]  H. Daniel,et al.  NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis , 2018, Scientific Reports.

[5]  D. Merlin,et al.  Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease. , 2018, Comprehensive Physiology.

[6]  T. Gonen,et al.  Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state , 2018, Nature Structural & Molecular Biology.

[7]  C. Löw,et al.  Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter , 2018, Structure.

[8]  L. Coutellier,et al.  Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress , 2017, Molecular Neurobiology.

[9]  H. S. Hundal,et al.  Effects of Sodium and Amino Acid Substrate Availability upon the Expression and Stability of the SNAT2 (SLC38A2) Amino Acid Transporter , 2018, Front. Pharmacol..

[10]  S. Newstead,et al.  Structural basis for amino acid transport by the CAT family of SLC7 transporters , 2018, Nature Communications.

[11]  E. Lee,et al.  Role of SLC7A5 in Metabolic Reprogramming of Human Monocyte/Macrophage Immune Responses , 2018, Front. Immunol..

[12]  P. Gasparini,et al.  Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss , 2018, eLife.

[13]  Joe T. Sharick,et al.  Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models , 2017, Nature Medicine.

[14]  G. Voth,et al.  Proton movement and coupling in the POT family of peptide transporters , 2017, Proceedings of the National Academy of Sciences.

[15]  D. Thwaites,et al.  Resculpting the binding pocket of APC superfamily LeuT-fold amino acid transporters , 2017, Cellular and Molecular Life Sciences.

[16]  Gregory A. Wyant,et al.  mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient , 2017, Cell.

[17]  F. Abe,et al.  Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae. , 2017, Biochimica et biophysica acta. Biomembranes.

[18]  Min Liu,et al.  Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter , 2017, Proceedings of the National Academy of Sciences.

[19]  D. Calvisi,et al.  A functional mammalian target of rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis , 2017, Hepatology.

[20]  A. Murphy,et al.  Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice. , 2017, Cell metabolism.

[21]  D. Levy,et al.  Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease. , 2017, Kidney international.

[22]  Simone Brogi,et al.  Synthesis and Biological Evaluation of Novel Neuroprotective Pyridazine Derivatives as Excitatory Amino Acid Transporter 2 (EAAT2) Activators. , 2017, Journal of medicinal chemistry.

[23]  M. Bianchi,et al.  GPNA inhibits the sodium-independent transport system l for neutral amino acids , 2017, Amino Acids.

[24]  M. Kavanaugh,et al.  Photoswitchable Inhibitor of a Glutamate Transporter. , 2017, ACS chemical neuroscience.

[25]  K. Rajapakshe,et al.  Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer , 2017, Molecular Cancer Research.

[26]  Kenji F. Tanaka,et al.  OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior , 2017, Proceedings of the National Academy of Sciences.

[27]  J. Mi,et al.  Amino acid transporter SLC38A3 promotes metastasis of non-small cell lung cancer cells by activating PDK1. , 2017, Cancer letters.

[28]  V. Prado,et al.  Cholinergic/glutamatergic co‐transmission in striatal cholinergic interneurons: new mechanisms regulating striatal computation , 2017, Journal of neurochemistry.

[29]  M. Jadot,et al.  SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells , 2017, Proceedings of the National Academy of Sciences.

[30]  Christian Rosenmund,et al.  Characterization of a Human Point Mutation of VGLUT3 (p.A211V) in the Rodent Brain Suggests a Nonuniform Distribution of the Transporter in Synaptic Vesicles , 2017, The Journal of Neuroscience.

[31]  A. Frick,et al.  Abnormal wiring of CCK+ basket cells disrupts spatial information coding , 2017, Nature Neuroscience.

[32]  I. Eberini,et al.  Novel insights into the transport mechanism of the human amino acid transporter LAT1 (SLC7A5). Probing critical residues for substrate translocation. , 2017, Biochimica et biophysica acta. General subjects.

[33]  R. Salomon,et al.  Renal involvement in lysinuric protein intolerance: contribution of pathology to assessment of heterogeneity of renal lesions. , 2017, Human pathology.

[34]  L. Abrahmsén,et al.  Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation , 2017, Nature Communications.

[35]  R. Zoncu,et al.  Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex , 2017, Science.

[36]  Naomi R. Latorraca,et al.  Mechanism of Substrate Translocation in an Alternating Access Transporter , 2017, Cell.

[37]  G. Krause,et al.  Thyroid hormone transport across L-type amino acid transporters: What can molecular modelling tell us? , 2017, Molecular and Cellular Endocrinology.

[38]  N. Reyes,et al.  Structure and allosteric inhibition of excitatory amino acid transporter 1 , 2017, Nature.

[39]  M. A. Sutton,et al.  Vesicular Glutamate Transporter Inhibitors: Structurally Modified Brilliant Yellow Analogs , 2017, Neurochemical Research.

[40]  H. Williams,et al.  Mutations in SLC25A22: hyperprolinaemia, vacuolated fibroblasts and presentation with developmental delay , 2017, Journal of Inherited Metabolic Disease.

[41]  P. Luppi,et al.  Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder , 2017, Brain : a journal of neurology.

[42]  J. Morrison,et al.  Age and Alzheimer’s disease gene expression profiles reversed by the glutamate modulator riluzole , 2017, Molecular Psychiatry.

[43]  S. Scheuring,et al.  Direct visualization of glutamate transporter elevator mechanism by high-speed AFM , 2017, Proceedings of the National Academy of Sciences.

[44]  Jun Wan,et al.  The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling , 2017, Aging cell.

[45]  M. Hirata,et al.  Integrated analysis of miRNA and mRNA gene expression microarrays: Influence on platelet reactivity, clopidogrel response and drug-induced toxicity. , 2016, Gene.

[46]  Ji-Soo Kim,et al.  Late-onset episodic ataxia associated with SLC1A3 mutation , 2016, Journal of Human Genetics.

[47]  H. Yoo,et al.  Biochemical and molecular characteristics of citrin deficiency in Korean children , 2016, Journal of Human Genetics.

[48]  Huajun Fan,et al.  MicroRNA-593-3p regulates insulin-promoted glucose consumption by targeting Slc38a1 and CLIP3. , 2016, Journal of molecular endocrinology.

[49]  Jun Yu,et al.  SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate. , 2016, Gastroenterology.

[50]  M. Mattson,et al.  The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons , 2016, Scientific Reports.

[51]  A. De Grassi,et al.  AGC1/2, the mitochondrial aspartate-glutamate carriers. , 2016, Biochimica et biophysica acta.

[52]  Lori A. Coburn,et al.  The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria , 2016, PLoS pathogens.

[53]  Y. Bhutia,et al.  Glutamine transporters in mammalian cells and their functions in physiology and cancer. , 2016, Biochimica et biophysica acta.

[54]  H. Kuwano,et al.  Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma , 2016, Cancer science.

[55]  J. Park,et al.  Polymorphisms in cancer-related pathway genes and lung cancer , 2016, European Respiratory Journal.

[56]  Michael R. Johnson,et al.  De Novo Mutations in SLC1A2 and CACNA1A Are Important Causes of Epileptic Encephalopathies. , 2016, American journal of human genetics.

[57]  P. Rathjen,et al.  Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters , 2016, Mechanisms of Development.

[58]  F. Alkuraya,et al.  Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans , 2016, Human Genetics.

[59]  G. D. De Benedetto,et al.  Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia* , 2016, The Journal of Biological Chemistry.

[60]  C. Wagner,et al.  Regulation and function of the SLC38A3/SNAT3 glutamine transporter , 2016, Channels.

[61]  J. Köhrle,et al.  Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10. , 2016, Molecular endocrinology.

[62]  R. Edwards,et al.  Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism , 2016, Neuron.

[63]  S. Bröer,et al.  Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells* , 2016, The Journal of Biological Chemistry.

[64]  R. Evans,et al.  ERRγ Is Required for the Metabolic Maturation of Therapeutically Functional Glucose-Responsive β Cells. , 2016, Cell metabolism.

[65]  T. Herbert,et al.  System-L amino acid transporters play a key role in pancreatic β-cell signalling and function. , 2016, Journal of molecular endocrinology.

[66]  Y. Aoki,et al.  Mitochondrial Aspartate/Glutamate Carrier SLC25A12 and Autism Spectrum Disorder: a Meta-Analysis , 2016, Molecular Neurobiology.

[67]  M. Leuenberger,et al.  Concise Asymmetric Synthesis and Pharmacological Characterization of All Stereoisomers of Glutamate Transporter Inhibitor TFB-TBOA and Synthesis of EAAT Photoaffinity Probes. , 2016, ACS chemical neuroscience.

[68]  Kohei Hagiwara,et al.  Specific transport of 3‐fluoro‐l‐α‐methyl‐tyrosine by LAT1 explains its specificity to malignant tumors in imaging , 2016, Cancer science.

[69]  Tom R. Gaunt,et al.  Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels , 2016, Nature Communications.

[70]  S. Bröer,et al.  Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney , 2016, Pflügers Archiv - European Journal of Physiology.

[71]  R. Jaenisch,et al.  Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity , 2015, eLife.

[72]  S. Kuyucak,et al.  Computational Studies of Glutamate Transporters , 2015, Biomolecules.

[73]  M. Skowrońska,et al.  Induction of inducible nitric oxide synthase expression in ammonia‐exposed cultured astrocytes is coupled to increased arginine transport by upregulated y+LAT2 transporter , 2015, Journal of neurochemistry.

[74]  Christian M. Metallo,et al.  Branched chain amino acid catabolism fuels adipocyte differentiation and lipogenesis , 2015, Nature chemical biology.

[75]  Lily S. Cheung,et al.  Structure of a eukaryotic SWEET transporter in a homotrimeric complex , 2015, Nature.

[76]  W. Ritchie,et al.  ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer , 2015, Oncogene.

[77]  D. Lancet,et al.  SLC1A4 mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum , 2015, Clinical genetics.

[78]  Christian Gieger,et al.  Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality , 2015, PLoS genetics.

[79]  M. Ruberg,et al.  Hypomorphic variants of cationic amino acid transporter 3 in males with autism spectrum disorders , 2015, Amino Acids.

[80]  M. Kitazawa,et al.  Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease , 2015, Neurobiology of Aging.

[81]  Jun Liu,et al.  Association between genetic variants in SLC25A12 and risk of autism spectrum disorders: An integrated meta‐analysis , 2015, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[82]  V. Haroutunian,et al.  Glutamate transporter splice variant expression in an enriched pyramidal cell population in schizophrenia , 2015, Translational Psychiatry.

[83]  M. Monné,et al.  Mitochondrial transporters for ornithine and related amino acids: a review , 2015, Amino Acids.

[84]  M. Nandave,et al.  Emerging roles of system antiporter and its inhibition in CNS disorders , 2015, Molecular membrane biology.

[85]  A. Serra,et al.  Impaired expression of key molecules of ammoniagenesis underlies renal acidosis in a rat model of chronic kidney disease. , 2015, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[86]  U. Sundaram,et al.  Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation , 2015, BMC Gastroenterology.

[87]  M. Gleave,et al.  Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development , 2015, The Journal of pathology.

[88]  R. Fredriksson,et al.  Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. , 2015, Journal of molecular biology.

[89]  A. V. Vulto-van Silfhout,et al.  Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems. , 2015, American journal of human genetics.

[90]  I. Kato,et al.  Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2 , 2015, Cancer science.

[91]  R. Fingerhut,et al.  Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development , 2015, The Journal of physiology.

[92]  H. S. Hundal,et al.  Proteasomal Modulation of Cellular SNAT2 (SLC38A2) Abundance and Function by Unsaturated Fatty Acid Availability* , 2015, The Journal of Biological Chemistry.

[93]  Qinghua Wang,et al.  GABAergic system in the endocrine pancreas: a new target for diabetes treatment , 2015, Diabetes, metabolic syndrome and obesity : targets and therapy.

[94]  S. Oliet,et al.  Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission , 2015, Nature Neuroscience.

[95]  Toshiharu Suzuki,et al.  Vesicular Glutamate Transporters Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter , 2014, Neuron.

[96]  Thijs J. Hagenbeek,et al.  L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia , 2014, Leukemia.

[97]  G. Superti-Furga,et al.  SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1 , 2014, Nature.

[98]  A. McQuillin,et al.  Association of rare variation in the glutamate receptor gene SLC1A2 with susceptibility to bipolar disorder and schizophrenia , 2014, European Journal of Human Genetics.

[99]  M. Nakajima,et al.  Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia. , 2014, Biochemical and biophysical research communications.

[100]  E. Fukusaki,et al.  Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion , 2014, Cell reports.

[101]  S. Yokoyama,et al.  The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production. , 2014, Immunity.

[102]  E. Foran,et al.  Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization , 2014, Glia.

[103]  C. Kahn,et al.  ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes , 2014, Science Translational Medicine.

[104]  P. Nordlund,et al.  Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2 , 2014, Nature Structural &Molecular Biology.

[105]  R. Chen,et al.  The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation , 2014, The Journal of cell biology.

[106]  T. Salt,et al.  Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex , 2014, Neurochemistry International.

[107]  A. Ortega,et al.  Expression of the System N transporter (SNAT5/SN2) during development indicates its plausible role in glutamatergic neurotransmission , 2014, Neurochemistry International.

[108]  J. Lyons,et al.  Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters , 2014, EMBO reports.

[109]  K. Sugden,et al.  Effects of antidepressant drug exposure on gene expression in the developing cerebral cortex , 2014, Synapse.

[110]  S. Welford,et al.  Expression of Glutamine Transporter Slc38a3 (SNAT3) During Acidosis is Mediated by a Different Mechanism than Tissue-Specific Expression , 2014, Cellular Physiology and Biochemistry.

[111]  J. Rasko,et al.  Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth , 2014, ACS chemical biology.

[112]  Jinyu Wu,et al.  SLC7A14 linked to autosomal recessive retinitis pigmentosa , 2014, Nature Communications.

[113]  E. Gouaux,et al.  How LeuT shapes our understanding of the mechanisms of sodium‐coupled neurotransmitter transporters , 2014, The Journal of physiology.

[114]  L. Cantley,et al.  Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.

[115]  Kristin Arnsburg,et al.  Interrelation Between Protein Synthesis, Proteostasis and Life Span , 2014, Current genomics.

[116]  G. Parisi,et al.  UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation , 2014, Proceedings of the National Academy of Sciences.

[117]  John Bradbury,et al.  Recessive mutations in SLC38A8 cause foveal hypoplasia and optic nerve misrouting without albinism. , 2013, American journal of human genetics.

[118]  T. Rauen,et al.  Functional Properties of the Retinal Glutamate Transporters GLT-1c and EAAT5* , 2013, The Journal of Biological Chemistry.

[119]  L. F. Waanders,et al.  Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice* , 2013, The Journal of Biological Chemistry.

[120]  Jun Liu,et al.  SLC3A1 and SLC7A9 mutations in autosomal recessive or dominant canine cystinuria: a new classification system. , 2013, Journal of veterinary internal medicine.

[121]  M. Gleave,et al.  Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development. , 2013, Journal of the National Cancer Institute.

[122]  C. Caggese,et al.  Mitochondrial glutamate carriers from Drosophila melanogaster: biochemical, evolutionary and modeling studies. , 2013, Biochimica et biophysica acta.

[123]  O. Birk,et al.  Isolated foveal hypoplasia with secondary nystagmus and low vision is associated with a homozygous SLC38A8 mutation , 2013, European Journal of Human Genetics.

[124]  G. Uhl,et al.  Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes , 2013, PloS one.

[125]  M. Rietschel,et al.  Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment , 2013, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[126]  P. Nordlund,et al.  Structural insights into substrate recognition in proton‐dependent oligopeptide transporters , 2013, EMBO reports.

[127]  S. Nikkari,et al.  Contribution of SLC7A1 genetic variant to hypertension, the TAMRISK study , 2013, BMC Medical Genetics.

[128]  T. Oyama,et al.  Diagnostic usefulness of 18F-FAMT PET and L-type amino acid transporter 1 (LAT1) expression in oral squamous cell carcinoma , 2013, European Journal of Nuclear Medicine and Molecular Imaging.

[129]  Y. Sugita,et al.  Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT , 2013, Proceedings of the National Academy of Sciences.

[130]  S. Lipton,et al.  Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss , 2013, Proceedings of the National Academy of Sciences.

[131]  Edmund R. S. Kunji,et al.  Lipid, Detergent, and Coomassie Blue G-250 Affect the Migration of Small Membrane Proteins in Blue Native Gels , 2013, The Journal of Biological Chemistry.

[132]  J. Foster,et al.  SLC6 transporters: structure, function, regulation, disease association and therapeutics. , 2013, Molecular aspects of medicine.

[133]  M. Leuenberger,et al.  The SLC1 high-affinity glutamate and neutral amino acid transporter family. , 2013, Molecular aspects of medicine.

[134]  M. Hediger,et al.  The ABCs of membrane transporters in health and disease (SLC series): Introduction , 2013, Molecular aspects of medicine.

[135]  R. Reimer SLC17: a functionally diverse family of organic anion transporters. , 2013, Molecular aspects of medicine.

[136]  D. Fotiadis,et al.  The SLC3 and SLC7 families of amino acid transporters. , 2013, Molecular aspects of medicine.

[137]  A. Sali,et al.  Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1 , 2013, Proceedings of the National Academy of Sciences of the United States of America.

[138]  B. Beutler,et al.  Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus , 2013, Proceedings of the National Academy of Sciences.

[139]  M. Rodríguez-Moran,et al.  Association of the polymorphisms 292 C>T and 1304 G>A in the SLC38A4 gene with hyperglycaemia , 2013, Diabetes/metabolism research and reviews.

[140]  M. Malumbres,et al.  HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. , 2012, Molecular cell.

[141]  M. Palacín,et al.  T‐type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control , 2012, The Journal of physiology.

[142]  L. Bunch,et al.  Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. , 2012, Bioorganic & medicinal chemistry.

[143]  B. André,et al.  Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy , 2012, Proceedings of the National Academy of Sciences.

[144]  P. Finan,et al.  TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. , 2012, Molecular cell.

[145]  Keigo Endo,et al.  Transport of 3-Fluoro-l-α-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET , 2012, The Journal of Nuclear Medicine.

[146]  B. Liu,et al.  LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis , 2012, Science.

[147]  A. Pinto,et al.  Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B. , 2012, Biochemistry.

[148]  M. Topf,et al.  Mutations in the GlyT2 Gene (SLC6A5) Are a Second Major Cause of Startle Disease* , 2012, The Journal of Biological Chemistry.

[149]  R. Boldrini,et al.  Distribution of cystinosin-LKG in human tissues , 2012, Histochemistry and Cell Biology.

[150]  V. Saudek Cystinosin, MPDU1, SWEETs and KDELR Belong to a Well-Defined Protein Family with Putative Function of Cargo Receptors Involved in Vesicle Trafficking , 2012, PloS one.

[151]  A. Robinson,et al.  Substrate Specificity of the Two Mitochondrial Ornithine Carriers Can Be Swapped by Single Mutation in Substrate Binding Site* , 2012, The Journal of Biological Chemistry.

[152]  G. Bellenchi,et al.  Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin , 2012, Proceedings of the National Academy of Sciences.

[153]  C. Perez,et al.  Role of bundle helices in a regulatory crosstalk in the trimeric betaine transporter BetP. , 2011, Journal of molecular biology.

[154]  Stephan J Sanders,et al.  Use of array CGH to detect exonic copy number variants throughout the genome in autism families detects a novel deletion in TMLHE. , 2011, Human molecular genetics.

[155]  M. Glicksman,et al.  Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. , 2011, Bioorganic & medicinal chemistry letters.

[156]  P. Newsholme,et al.  L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge. , 2011, The Journal of endocrinology.

[157]  D. Attwell,et al.  A Role for Glutamate Transporters in the Regulation of Insulin Secretion , 2011, PloS one.

[158]  V. Ganapathy,et al.  SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer* , 2011, The Journal of Biological Chemistry.

[159]  S. Bröer,et al.  The role of amino acid transporters in inherited and acquired diseases. , 2011, The Biochemical journal.

[160]  S. Golz,et al.  OAT2 catalyses efflux of glutamate and uptake of orotic acid. , 2011, The Biochemical journal.

[161]  Ignacio Fita,et al.  Crystal structure of a substrate-bound amino acid antiporter in the outward open conformation: mechanism of substrate recognintion and transport. , 2011 .

[162]  R. Vandenberg,et al.  Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. , 2011, The Journal of clinical investigation.

[163]  C. Bundgaard,et al.  Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). , 2010, Journal of medicinal chemistry.

[164]  E. Tajkhorshid,et al.  Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter. , 2010, Biophysical journal.

[165]  Lorenz C. Blum,et al.  Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). , 2010, Journal of medicinal chemistry.

[166]  S. Bröer,et al.  Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. , 2010, The Biochemical journal.

[167]  H. Shin,et al.  A new association between polymorphisms of the SLC6A7 gene in the chromosome 5q31–32 region and asthma , 2010, Journal of Human Genetics.

[168]  K. Seyb,et al.  Identification of Translational Activators of Glial Glutamate Transporter EAAT2 through Cell-Based High-Throughput Screening , 2010, Journal of biomolecular screening.

[169]  J. Ko,et al.  Novel mutation in SLC6A19 causing late-onset seizures in Hartnup disorder. , 2010, Pediatric neurology.

[170]  Yigong Shi,et al.  Mechanism of substrate recognition and transport by an amino acid antiporter , 2010, Nature.

[171]  N. Reyes,et al.  Transport mechanism of a bacterial homologue of glutamate transporters , 2009, Nature.

[172]  H. Daniel,et al.  Projection structure of DtpD (YbgH), a prokaryotic member of the peptide transporter family. , 2009, Journal of molecular biology.

[173]  Ying Wang,et al.  Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus , 2009, Nature Genetics.

[174]  A. Hofman,et al.  The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression , 2011, Neuron.

[175]  E. Gouaux,et al.  Structure and Mechanism of a Na+-Independent Amino Acid Transporter , 2009, Science.

[176]  Yigong Shi,et al.  Structure and Mechanism of an Amino Acid Antiporter , 2009, Science.

[177]  M. Baumgartner,et al.  Identification of novel mutations in the SLC25A15 gene in hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome: A clinical, molecular, and functional study , 2009, Human mutation.

[178]  Adiel Cohen,et al.  An Amino Acid Shuffle Activates mTORC1 , 2009, Cell.

[179]  Jeffrey P. MacKeigan,et al.  Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy , 2009, Cell.

[180]  Eric Gouaux,et al.  A Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation , 2008, Science.

[181]  Anthony Mancuso,et al.  Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction , 2008, Proceedings of the National Academy of Sciences.

[182]  S. Bröer,et al.  Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. , 2008, The Journal of clinical investigation.

[183]  H. Nury,et al.  Mitochondrial bovine ADP/ATP carrier in detergent is predominantly monomeric but also forms multimeric species. , 2008, Biochemistry.

[184]  M. Tomi,et al.  Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents. , 2008, Biological & pharmaceutical bulletin.

[185]  David M. Sabatini,et al.  The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.

[186]  L. Mannucci,et al.  Identification and subcellular localization of a new cystinosin isoform. , 2008, American journal of physiology. Renal physiology.

[187]  M. Gobbi,et al.  Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. , 2008, European journal of pharmacology.

[188]  S. Amara,et al.  Enhancing Glutamate Transport: Mechanism of Action of Parawixin1, a Neuroprotective Compound from Parawixia bistriata Spider Venom , 2007, Molecular Pharmacology.

[189]  Emily F. Stone,et al.  The Glutamate and Chloride Permeation Pathways Are Colocalized in Individual Neuronal Glutamate Transporter Subunits , 2007, The Journal of Neuroscience.

[190]  H. Larsson,et al.  The Glutamate-Activated Anion Conductance in Excitatory Amino Acid Transporters Is Gated Independently by the Individual Subunits , 2007, The Journal of Neuroscience.

[191]  Eric Gouaux,et al.  Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter , 2007, Nature.

[192]  T. Usui,et al.  Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L. , 2006, Chemistry & biology.

[193]  Masahiko Watanabe,et al.  Indispensability of the glutamate transporters GLAST and GLT1 to brain development , 2006, Proceedings of the National Academy of Sciences.

[194]  C. Fahlke,et al.  Intersubunit Interactions in EAAT4 Glutamate Transporters , 2006, The Journal of Neuroscience.

[195]  Anita Shah,et al.  System B0,+ amino acid transport regulates the penetration stage of blastocyst implantation with possible long-term developmental consequences through adulthood. , 2006, Human reproduction update.

[196]  B. van Yserloo,et al.  Identification and characterization of a novel isoform of the vesicular gamma-aminobutyric acid transporter with glucose-regulated expression in rat islets. , 2006, Journal of molecular endocrinology.

[197]  L. Bunch,et al.  Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3. , 2006, Journal of medicinal chemistry.

[198]  Q. Lu,et al.  Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2. , 2005, Bioorganic & medicinal chemistry letters.

[199]  K. Fan,et al.  Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2 , 2005, Molecular Pharmacology.

[200]  T. Rauen,et al.  Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. , 2005, Biochemistry.

[201]  R. Bridges,et al.  The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes. , 2005, Pharmacology & therapeutics.

[202]  E. Gouaux,et al.  Structure of a glutamate transporter homologue from Pyrococcus horikoshii , 2004, Nature.

[203]  E. Closs,et al.  Plasma membrane transporters for arginine. , 2004, The Journal of nutrition.

[204]  N. Curthoys,et al.  Glutamine metabolism: Role in acid‐base balance * , 2004, Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology.

[205]  S. Amara,et al.  Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. , 2004, Molecular pharmacology.

[206]  H. Sitte,et al.  Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking. , 2004, Molecular interventions.

[207]  Kaisa Silander,et al.  The SLC6A14 gene shows evidence of association with obesity. , 2003, The Journal of clinical investigation.

[208]  S. Eliasof,et al.  WAY‐855 (3‐amino‐tricyclo[2.2.1.02.6]heptane‐1,3‐dicarboxylic acid): a novel, EAAT2‐preferring, nonsubstrate inhibitor of high‐affinity glutamate uptake , 2003, British journal of pharmacology.

[209]  John E. Walker,et al.  The Mitochondrial Ornithine Transporter , 2003, Journal of Biological Chemistry.

[210]  S. Amara,et al.  Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake , 2003, British journal of pharmacology.

[211]  S. Bröer Adaptation of plasma membrane amino acid transport mechanisms to physiological demands , 2002, Pflügers Archiv.

[212]  Y. Kanai,et al.  Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. , 2002, Molecular pharmacology.

[213]  C. Meier,et al.  Activation of system L heterodimeric amino acid exchangers by intracellular substrates , 2002, The EMBO journal.

[214]  C. Antignac,et al.  Cystinosin, the protein defective in cystinosis, is a H+‐driven lysosomal cystine transporter , 2001, The EMBO journal.

[215]  B. Bode Recent molecular advances in mammalian glutamine transport. , 2001, The Journal of nutrition.

[216]  M. Yudkoff,et al.  The glutamine/glutamate couplet and cellular function. , 2001, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[217]  Y. Kanai,et al.  Expression Cloning of a Na+-independent Aromatic Amino Acid Transporter with Structural Similarity to H+/Monocarboxylate Transporters* , 2001, The Journal of Biological Chemistry.

[218]  C. Antignac,et al.  The Targeting of Cystinosin to the Lysosomal Membrane Requires a Tyrosine-based Signal and a Novel Sorting Motif* , 2001, The Journal of Biological Chemistry.

[219]  V. Ganapathy,et al.  Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. , 2001, Biochimica et biophysica acta.

[220]  M. López-Fontanals,et al.  The role of system A for neutral amino acid transport in the regulation of cell volume , 2001, Molecular membrane biology.

[221]  Y. Shigeri,et al.  Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. , 2000, Bioorganic & medicinal chemistry letters.

[222]  T. Tsuruo,et al.  The 4F2hc/LAT1 complex transports l-DOPA across the blood–brain barrier , 2000, Brain Research.

[223]  M. Hediger,et al.  Functional roles of histidine and tyrosine residues in the H(+)-peptide transporter PepT1. , 2000, Biochemical and biophysical research communications.

[224]  I. Paulsen,et al.  New Glycoprotein-Associated Amino Acid Transporters , 1999, The Journal of Membrane Biology.

[225]  C. Antignac,et al.  Severity of phenotype in cystinosis varies with mutations in the CTNS gene: predicted effect on the model of cystinosin. , 1999, Human molecular genetics.

[226]  M. Kavanaugh,et al.  Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters. , 1999, Molecular pharmacology.

[227]  M. Hediger Glutamate transporters in kidney and brain. , 1999, American journal of physiology. Renal physiology.

[228]  J. Matthews,et al.  Glutamate transport and renal function. , 1999, American journal of physiology. Renal physiology.

[229]  M. Hediger,et al.  Introduction: glutamate transport, metabolism, and physiological responses. , 1999, The American journal of physiology.

[230]  Y. Anikster,et al.  Mutations of CTNS causing intermediate cystinosis. , 1999, Molecular genetics and metabolism.

[231]  W. Gahl,et al.  CTNS mutations in an American-based population of cystinosis patients. , 1998, American journal of human genetics.

[232]  M. Palacín,et al.  Molecular biology of mammalian plasma membrane amino acid transporters. , 1998, Physiological reviews.

[233]  O. Gribouval,et al.  A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis , 1998, Nature Genetics.

[234]  Y. Shigeri,et al.  DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. , 1998, Molecular pharmacology.

[235]  K. Shimamoto,et al.  New β-Hydroxyaspartate Derivatives Are Competitive Blockers for the Bovine Glutamate/Aspartate Transporter* , 1997, The Journal of Biological Chemistry.

[236]  H. Daniel,et al.  Target size analysis of the peptide/H(+)-symporter in kidney brush-border membranes. , 1995, Biochimica et biophysica acta.

[237]  M. Romero,et al.  Expression cloning of a mammalian proton-coupled oligopeptide transporter , 1994, Nature.

[238]  T. Ishii,et al.  Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer. , 2017, American journal of translational research.

[239]  S. Bröer The SLC38 family of sodium–amino acid co-transporters , 2013, Pflügers Archiv - European Journal of Physiology.

[240]  Y. Kanai,et al.  Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters. , 2008, Journal of pharmacological sciences.

[241]  F. Chaudhry,et al.  Pharmacology of neurotransmitter transport into secretory vesicles. , 2008, Handbook of experimental pharmacology.

[242]  J. Glazier,et al.  SNAT4 isoform of system A amino acid transporter is expressed in human placenta. , 2006, American journal of physiology. Cell physiology.

[243]  J. Matthews,et al.  Recent advances in amino acid transporters and excitatory amino acid receptors. , 2002, Current opinion in clinical nutrition and metabolic care.

[244]  H. Christensen,et al.  Role of amino acid transport and countertransport in nutrition and metabolism. , 1990, Physiological reviews.