Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.

[1]  D. Wismeijer,et al.  Activation of PGC-1α -dependent mitochondrial biogenesis supports therapeutic effects of silibinin against type I diabetic periodontitis. , 2023, Journal of clinical periodontology.

[2]  T. Ikejima,et al.  Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[3]  Y. Liu,et al.  Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. , 2022, Journal of ethnopharmacology.

[4]  Min Chen,et al.  Glutathione Peroxidase 4 Is a Predictor of Diabetic Kidney Disease Progression in Type 2 Diabetes Mellitus , 2022, Oxidative medicine and cellular longevity.

[5]  Myung-Shik Lee,et al.  Mitochondrial event as an ultimate step in ferroptosis , 2022, Cell Death Discovery.

[6]  Aubry K. Miller,et al.  Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals , 2022, Nature Chemical Biology.

[7]  Tao Wang,et al.  Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis , 2022, Stem cell research & therapy.

[8]  Zijun Wu,et al.  Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis. , 2022, Journal of the American Chemical Society.

[9]  M. Lotz,et al.  Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis , 2022, Aging cell.

[10]  T. Nyström,et al.  Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo , 2022, Nature Metabolism.

[11]  V. Castronovo,et al.  Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells , 2022, Redox biology.

[12]  Lin Fu,et al.  Arsenic induces ferroptosis and acute lung injury through mtROS-mediated mitochondria-associated endoplasmic reticulum membrane dysfunction. , 2022, Ecotoxicology and environmental safety.

[13]  Jianzhao Liao,et al.  NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2/Gpx4 pathway. , 2022, Free radical biology & medicine.

[14]  T. Ikejima,et al.  Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. , 2022, Toxicology in vitro : an international journal published in association with BIBRA.

[15]  Mengliang Zhou,et al.  Peroxisome proliferator-activated receptor-γ ameliorates neuronal ferroptosis after traumatic brain injury in mice by inhibiting cyclooxygenase-2 , 2022, Experimental Neurology.

[16]  H. Kiaris,et al.  The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2 , 2022, bioRxiv.

[17]  R. Dhaked,et al.  Silibinin ameliorates abrin induced hepatotoxicity by attenuating oxidative stress, inflammation and inhibiting Fas pathway. , 2022, Environmental toxicology and pharmacology.

[18]  V. Martinović,et al.  Ferroptosis as a Novel Determinant of β-Cell Death in Diabetic Conditions , 2022, Oxidative medicine and cellular longevity.

[19]  J. Chung,et al.  Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells , 2022, Cell Death & Disease.

[20]  Yuzhen Ke,et al.  Activation of osteoblast ferroptosis via the METTL3/ASK1‐p38 signaling pathway in high glucose and high fat (HGHF)‐induced diabetic bone loss , 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  Xiaopeng Li,et al.  The multifaceted role of ferroptosis in liver disease , 2022, Cell Death & Differentiation.

[22]  S. Mandrup,et al.  Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells , 2022, Diabetologia.

[23]  G. Celenza,et al.  Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis , 2021, Cells.

[24]  T. Ikejima,et al.  Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway , 2021, Acta pharmacologica Sinica.

[25]  Wenqing Li,et al.  TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells , 2021, Oxidative medicine and cellular longevity.

[26]  L. Satin,et al.  New Aspects of Diabetes Research and Therapeutic Development , 2021, Pharmacological Reviews.

[27]  Y. Xi,et al.  Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus , 2021, Journal of diabetes research.

[28]  Wanyue Huang,et al.  Protective effect of mitophagy against aluminum-induced MC3T3-E1 cells dysfunction. , 2021, Chemosphere.

[29]  P. Zabielski,et al.  Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes , 2021, Frontiers in Endocrinology.

[30]  Maowei Yang,et al.  Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis , 2021, Biological Trace Element Research.

[31]  É. B. Rangel,et al.  Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity , 2021, International journal of molecular sciences.

[32]  Nai-Feng Liu,et al.  Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects. , 2021, Free radical biology & medicine.

[33]  Zuguo Liu,et al.  Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance , 2020, The Journal of biological chemistry.

[34]  D. Yan,et al.  Metabolite biomarkers of type 2 diabetes mellitus and pre-diabetes: a systematic review and meta-analysis , 2020, BMC Endocrine Disorders.

[35]  J. Chung,et al.  Ethanolic Extract of Vaccinium corymbosum Alleviates Muscle Fatigue in Mice. , 2020, Journal of medicinal food.

[36]  D. Tang,et al.  Iron Metabolism in Ferroptosis , 2020, Frontiers in Cell and Developmental Biology.

[37]  Chunjie Jiang,et al.  Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes , 2020, Nutrients.

[38]  Tianshu Wu,et al.  Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia , 2020, Particle and Fibre Toxicology.

[39]  Xuanzhe Liu,et al.  Morroniside attenuates high glucose–induced BMSC dysfunction by regulating the Glo1/AGE/RAGE axis , 2020, Cell proliferation.

[40]  Yi Zhou The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis , 2020, Diabetes, metabolic syndrome and obesity : targets and therapy.

[41]  J. Holloszy,et al.  Exercise Training-Induced PPARβ Increases PGC-1α Protein Stability and Improves Insulin-Induced Glucose Uptake in Rodent Muscles , 2020, Nutrients.

[42]  A. Gillessen,et al.  Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review , 2020, Advances in Therapy.

[43]  V. Dhawan,et al.  Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study , 2020, Journal of cellular and molecular medicine.

[44]  Can Liu,et al.  Mitochondria regulation in ferroptosis. , 2019, European journal of cell biology.

[45]  R. McCoy,et al.  Benefits and harms of intensive glycemic control in patients with type 2 diabetes , 2019, BMJ.

[46]  Fanxing Xu,et al.  Involvement of Estrogen Receptor-α in the Activation of Nrf2-Antioxidative Signaling Pathways by Silibinin in Pancreatic β-Cells , 2019, Biomolecules & therapeutics.

[47]  Edward W. Tate,et al.  FSP1 is a glutathione-independent ferroptosis suppressor , 2019, Nature.

[48]  Yun Sun,et al.  Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy , 2019, Cell Death & Disease.

[49]  T. Ikejima,et al.  Silibinin decreases hepatic glucose production through the activation of gut-brain-liver axis in diabetic rats. , 2018, Food & function.

[50]  T. Ikejima,et al.  Role of silibinin in the management of diabetes mellitus and its complications , 2018, Archives of Pharmacal Research.

[51]  T. Ikejima,et al.  Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[52]  B. Stockwell,et al.  Unsolved mysteries: How does lipid peroxidation cause ferroptosis? , 2018, PLoS biology.

[53]  A. Walch,et al.  Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis , 2017, Cell.

[54]  S. Ylä-Herttuala,et al.  Aggravated Postinfarct Heart Failure in Type 2 Diabetes Is Associated with Impaired Mitophagy and Exaggerated Inflammasome Activation. , 2017, The American journal of pathology.

[55]  C. Verchere,et al.  Improving glycemic control in type 2 diabetes : stimulate insulin secretion or provide beta-cell rest ? , 2017 .

[56]  D. Tang,et al.  CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation. , 2016, Biochemical and biophysical research communications.

[57]  H. Bayır,et al.  Therapies targeting lipid peroxidation in traumatic brain injury , 2016, Brain Research.

[58]  J. Burman,et al.  The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy , 2015, Nature.

[59]  F. Wang,et al.  Silibinin protects β cells from glucotoxicity through regulation of the Insig-1/SREBP-1c pathway. , 2014, International journal of molecular medicine.

[60]  Yup Kang,et al.  Protective effect of nicotinamide on high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells is attributed to its inhibitory activity to sirtuins. , 2013, Archives of biochemistry and biophysics.

[61]  M. Diamant,et al.  Advances in Pharmacologic Therapies for Type 2 Diabetes , 2013, Current Atherosclerosis Reports.

[62]  H. Tian,et al.  Body Iron Stores and Heme-Iron Intake in Relation to Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis , 2012, PloS one.

[63]  A. Michalsen,et al.  Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial , 2012, BMC Medicine.

[64]  M. R. Lamprecht,et al.  Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death , 2012, Cell.

[65]  O. Shirihai,et al.  The interplay between mitochondrial dynamics and mitophagy. , 2011, Antioxidants & redox signaling.

[66]  Ji Zhang,et al.  Role of BNIP3 and NIX in cell death, autophagy, and mitophagy , 2009, Cell Death and Differentiation.

[67]  Lie-Chwen Lin,et al.  Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application. , 2007, Journal of pharmaceutical and biomedical analysis.

[68]  R. Robertson,et al.  Glutathione peroxidase protein expression and activity in human islets isolated for transplantation , 2007, Clinical transplantation.

[69]  P. Schrauwen,et al.  Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. , 2004, Diabetes.

[70]  S. Severi,et al.  Silybin, a new iron-chelating agent. , 2001, Journal of inorganic biochemistry.

[71]  César Martín,et al.  Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction. , 2021, International review of cell and molecular biology.