The impact of targeted training, a dedicated protocol and on‐site training material in reducing observer variability of prostate and transition zone dimensions measured by transrectal ultrasonography, in multicentre multinational clinical trials of men with symptomatic benign prostatic enlargement

To assess the variability of a standardized protocol of transrectal ultrasonography (TRUS), with targeted training, and compare it to the variability in other multicentre clinical trials, as TRUS‐estimated total prostate volume (TPV) and transition zone volume (TZV) are considered important efficacy endpoints in assessing new drug therapies for benign prostatic enlargement (BPE), but standardizing TRUS remains a challenge in such studies.

[1]  J. Bosch,et al.  Validity of three calliper‐based transrectal ultrasound methods and digital rectal examination in the estimation of prostate volume and its changes with age: The Krimpen study , 2005, The Prostate.

[2]  B. Nicolas Bloch,et al.  3 Tesla magnetic resonance imaging of the prostate with combined pelvic phased-array and endorectal coils; Initial experience(1). , 2004, Academic radiology.

[3]  P. Boyle,et al.  Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. , 2002, Urology.

[4]  Entezari,et al.  The importance of measuring the prostatic transition zone: an anatomical and radiological study , 1999, BJU international.

[5]  C. Roehrborn,et al.  Accurate determination of prostate size via digital rectal examination and transrectal ultrasound. , 1998, Urology.

[6]  C. Roehrborn,et al.  Microwave thermotherapy for benign prostatic hyperplasia with the Dornier Urowave: results of a randomized, double-blind, multicenter, sham-controlled trial. , 1998, Urology.

[7]  G N Collins,et al.  Correlation between prostate size estimated by digital rectal examination and measured by transrectal ultrasound. , 1997, Urology.

[8]  A L Gould,et al.  Prostate volume predicts outcome of treatment of benign prostatic hyperplasia with finasteride: meta-analysis of randomized clinical trials. , 1996, Urology.

[9]  M M Elhilali,et al.  Reassessment of nonplanimetric transrectal ultrasound prostate volume estimates. , 1996, Urology.

[10]  J E Wickham,et al.  Transrectal ultrasonography: why are estimates of prostate volume and dimension so inaccurate? , 1996, British journal of urology.

[11]  Fritz H. Schröder,et al.  Transrectal ultrasonic volumetry of the prostate: In vivo comparison of different methods , 1996, The Prostate.

[12]  A. Tewari,et al.  Transition zone volume and transition zone ratio: predictor of uroflow response to finasteride therapy in benign prostatic hyperplasia patients. , 1995, Urology.

[13]  W. Garraway,et al.  Reproducibility and observer variability of transrectal ultrasound measurements of prostatic volume. , 1995, Ultrasound in medicine & biology.

[14]  O. Löfman,et al.  Inter-observer variation in assessment of the prostate by digital rectal examination. , 1993, British journal of urology.

[15]  T. Egglin,et al.  Determination of prostate volume with transrectal US for cancer screening. Part I. Comparison with prostate-specific antigen assays. , 1991, Radiology.

[16]  C. Chan,et al.  Quantitative analysis of the accuracy of linear array transrectal ultrasound in measurement of the prostate. , 1991, British journal of urology.