Oral Contraceptives Induce Lamotrigine Metabolism: Evidence from a Double‐blind, Placebo‐controlled Trial

Summary:  Purpose: This study evaluates the effect of oral contraceptives on lamotrigine (LTG) plasma concentrations and urine excretion of LTG metabolites in a double‐blind, placebo‐controlled, crossover study in patients with epilepsy.

[1]  O. Beck,et al.  Determination of Lamotrigine and its Metabolites in Human Plasma by Liquid Chromatography-Mass Spectrometry , 2006, Therapeutic drug monitoring.

[2]  E. Leshinsky‐Silver,et al.  Congenital Hyperreninemic Hypoaldosteronism in Israel: Sequence Analysis of CYP11B2 Gene , 2006, Hormone Research in Paediatrics.

[3]  E. Brodtkorb,et al.  Lamotrigine Serum Concentrations Throughout the Menstrual Cycle-A Study of 2 Cases , 2006, Clinical neuropharmacology.

[4]  J. Sidhu,et al.  The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. , 2006, British journal of clinical pharmacology.

[5]  R. Tukey,et al.  Tissue-specific, Inducible, and Hormonal Control of the Human UDP-Glucuronosyltransferase-1 (UGT1) Locus* , 2005, Journal of Biological Chemistry.

[6]  E. Brodtkorb,et al.  Ethinyl Estradiol, Not Progestogens, Reduces Lamotrigine Serum Concentrations , 2005, Epilepsia.

[7]  M. Shipkova,et al.  Glucuronidation in therapeutic drug monitoring. , 2005, Clinica chimica acta; international journal of clinical chemistry.

[8]  A. Sabers,et al.  Individual changes in lamotrigine plasma concentrations during pregnancy , 2005, Epilepsy Research.

[9]  M. Engelsman,et al.  Gestation-induced changes in lamotrigine pharmacokinetics: A monotherapy study , 2004, Neurology.

[10]  B. Bourgeois,et al.  Efficacy and Tolerability of the New Antiepileptic Drugs, I: Treatment of New‐Onset Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society , 2004, Epilepsia.

[11]  B. Bourgeois,et al.  Efficacy and Tolerability of the New Antiepileptic Drugs, I: Treatment of New‐Onset Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society , 2004, Epilepsia.

[12]  M. Manns,et al.  Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP‐glucuronosyltransferase UGT1A4 , 2004, Hepatology.

[13]  P. Pennell,et al.  The impact of pregnancy and childbirth on the metabolism of lamotrigine , 2004, Neurology.

[14]  T. Tomson,et al.  Oral contraceptives reduce lamotrigine plasma levels , 2003, Neurology.

[15]  E. Perucca,et al.  Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs , 2003, The Lancet Neurology.

[16]  E. Perucca,et al.  Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs , 2003, The Lancet Neurology.

[17]  M. Bialer,et al.  Effect of Topiramate or Carbamazepine on the Pharmacokinetics of an Oral Contraceptive Containing Norethindrone and Ethinyl Estradiol in Healthy Obese and Nonobese Female Subjects , 2003, Epilepsia.

[18]  I. Leppik,et al.  Lamotrigine clearance during pregnancy , 2002, Neurology.

[19]  P. Crawford.  Interactions Between Antiepileptic Drugs and Hormonal Contraception , 2002, CNS drugs.

[20]  P. Uldall,et al.  Lamotrigine plasma levels reduced by oral contraceptives , 2001, Epilepsy Research.

[21]  J. Djurhuus,et al.  [The GCP-unit at the Aaarhus University Hospital]. , 2000, Ugeskrift for laeger.

[22]  J. Posner,et al.  Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data. , 1997, British journal of clinical pharmacology.

[23]  B. Burchell,et al.  Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol. , 1993, Molecular pharmacology.

[24]  I. Osorio,et al.  Antiepileptic Drug Intoxication: Factors and Their Significance , 1991, Epilepsia.