Miniaturized HTS technologies - uHTS.

[1]  R. Seethala,et al.  Handbook of drug screening , 2001 .

[2]  U. Haupts,et al.  Developments in fluorescence lifetime-based analysis for ultra-HTS , 2001 .

[3]  Ralf Thiericke,et al.  Evaluation of Liquid Handling Conditions in Microplates , 2001, Journal of biomolecular screening.

[4]  M. Lohse,et al.  Receptor-Ligand Interactions Studied with Homogeneous Fluorescence-Based Assays Suitable for Miniaturized Screening , 2001, Journal of biomolecular screening.

[5]  D A. Dunn,et al.  Challenges and solutions to ultra-high-throughput screening assay miniaturization: submicroliter fluid handling. , 2000, Drug discovery today.

[6]  Hrib,et al.  Chemoinformatics: are we exploiting this new science?. 'We need to make chemoinformatics tools more accessible to the bench chemist.' , 2000, Drug discovery today.

[7]  R. Hertzberg,et al.  High-throughput screening: new technology for the 21st century. , 2000, Current opinion in chemical biology.

[8]  Sean T. Quinn,et al.  Automated Assay Optimization with Integrated Statistics and Smart Robotics , 2000, Journal of biomolecular screening.

[9]  Oliver Bruttger,et al.  High Throughput Screening at the Nano Scale , 2000 .

[10]  J. Sportsman,et al.  Miniaturization of homogeneous assays using fluorescence polarization , 2000 .

[11]  I. Gibbons,et al.  Microfluidic arrays for high-throughput submicroliter assays using capillary electrophoresis , 2000 .

[12]  U. Haupts,et al.  Macroscopic versus microscopic fluorescence techniques in (ultra)-high-throughput screening , 2000 .

[13]  Daniel Chelsky,et al.  Miniaturizing screening: how low can we go today? , 2000 .

[14]  Bryn R. Roberts.  Screening informatics: adding value with meta-data structures and visualization tools , 2000 .

[15]  M Webb,et al.  Ultra-High Throughput Screen of Two-Million-Member Combinatorial Compound Collection in a Miniaturized, 1536-Well Assay Format , 2000, Journal of biomolecular screening.

[16]  A Tropsha,et al.  Recent trends in computer-aided drug discovery. , 2000, Current opinion in drug discovery & development.

[17]  M. Cronin,et al.  Computational methods for the prediction of drug toxicity. , 2000, Current opinion in drug discovery & development.

[18]  J H Zhang,et al.  Confirmation of primary active substances from high throughput screening of chemical and biological populations: a statistical approach and practical considerations. , 2000, Journal of combinatorial chemistry.

[19]  J. Jungmann,et al.  Two-dimensional fluorescence intensity distribution analysis: theory and applications. , 2000, Biophysical journal.

[20]  Gregory J. Parker,et al.  Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand-Binding and Kinase/Phosphatase Assays , 2000, Journal of biomolecular screening.

[21]  G. Whitesides,et al.  Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[22]  J J Burbaum,et al.  The Evolution of Miniaturized Well Plates , 2000, Journal of biomolecular screening.

[23]  Michael R. Knapp,et al.  Test Tube's End , 2000, Journal of biomolecular screening.

[24]  S A Sundberg,et al.  High-throughput and ultra-high-throughput screening: solution- and cell-based approaches. , 2000, Current opinion in biotechnology.

[25]  I. Hemmilä.  LANCE™: Homogeneous Assay Platform for HTS , 1999 .

[26]  Joseph R. Lakowicz,et al.  High Throughput Screening with Multiphoton Excitation , 1999, Journal of biomolecular screening.

[27]  Stephen Ashman,et al.  Single Molecule Detection Technologies in Miniaturized High Throughput Screening: Fluorescence Correlation Spectroscopy , 1999, Journal of biomolecular screening.

[28]  D. Ullmann,et al.  Fluorescence-intensity distribution analysis and its application in biomolecular detection technology. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. Michael Ramsey,et al.  The burgeoning power of the shrinking laboratory , 1999, Nature Biotechnology.

[30]  Ramm,et al.  Imaging systems in assay screening. , 1999, Drug discovery today.

[31]  Rose.  Microdispensing technologies in drug discovery. , 1999, Drug discovery today.

[32]  Mark Divers,et al.  What is the Future of High Throughput Screening? , 1999, Journal of biomolecular screening.

[33]  Peter J. Coassin,et al.  Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening. , 1999, Drug discovery today.

[34]  U. Haupts,et al.  Homogeneous fluorescence readouts for miniaturized high-throughput screening: theory and practice. , 1999, Drug discovery today.

[35]  Mark Beggs,et al.  The High Throughput Screening Infrastructure: The Right Tools for the Task , 1999, Journal of biomolecular screening.

[36]  Thomas D. Y. Chung,et al.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.

[37]  Steffen Howitz,et al.  Components and systems for microliquid handling , 1999 .

[38]  Mathis.  HTRF(R) Technology. , 1999, Journal of biomolecular screening.

[39]  D. J. Rose,et al.  Inkjet dispensing technology: applications in drug discovery. , 1998, Current opinion in biotechnology.

[40]  Manfred Auer,et al.  Fluorescence correlation spectroscopy: Lead discovery by miniaturized HTS , 1998 .

[41]  Roeland Papen,et al.  Nanolitre dispensing — a new innovation in robotic liquid handling , 1998 .

[42]  Matthew A. Sills,et al.  Future considerations in HTS: the acute effect of chronic dilemmas , 1998 .

[43]  Jonathan J. Burbaum,et al.  Miniaturization technologies in HTS: how fast, how small, how soon? , 1998 .

[44]  Willie Harrison,et al.  Changes in scale in automated pharmaceutical research , 1998 .

[45]  Patricia A. Johnston,et al.  Integration of Screen Development with HTS Operations Generates Significant Improvements in the Lead Generation Process , 1998 .

[46]  J. Broach,et al.  New assay technologies for high-throughput screening. , 1998, Current opinion in chemical biology.

[47]  Mark A. Murcko,et al.  Virtual screening : an overview , 1998 .

[48]  C. Seidel,et al.  Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[49]  J. Major.  Challenges and Opportunities in High Throughput Screening: Implications for New Technologies , 1998 .

[50]  Thomas D.Y. Chung,et al.  Assay Miniaturization for Ultra-High Throughput Screening of Combinatorial and Discrete Compound Libraries: A 9600-Well (0.2 Microliter) Assay System , 1998 .

[51]  G. Whitesides,et al.  A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells. , 1997, Chemistry & biology.

[52]  D. W. Brandt.  Multiplexed Nanoliter Transfers for High Throughput Drug Screening Using the Biomek 2000 and the High Density Replicating Tool , 1997 .

[53]  Jürgen Drews,et al.  Innovation Deficit in the Pharmaceutical Industry , 1996 .