Useless or Helpful? The "Limbic System" Concept

The "limbic system" is a widespread and frequently used concept in the neurosciences although it is characterized by many different and often vague or even contradictory definitions. This concept has therefore received an increasing amount of critique during the past years. An appraisal of various opinions - ranging from rejection to limited use and support - led us to suggestions concerning its appropriate use. Most importantly, the diversity of definitions and the weak empirical foundation require careful consideration as to what extent certain aspects of the "limbic system" concept can be useful heuristic tools in scientific reasoning.

[1]  R. Joseph,et al.  The limbic system: emotion, laterality, and unconscious mind. , 1992, Psychoanalytic review.

[2]  J. Gray,et al.  Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system , 1982, Behavioral and Brain Sciences.

[3]  K H PRIBRAM,et al.  Neuronographic analysis of medial and basal cerebral cortex. I. Cat. , 1953, Journal of neurophysiology.

[4]  P. Broca,et al.  Anatomie comparée des circonvolutions cérébrales : le grand lobe limbique et la scissure limbique dans la série des mammifères , 1878 .

[5]  P. Maclean.  Psychosomatic Disease and the "Visceral Brain": Recent Developments Bearing on the Papez Theory of Emotion , 1949, Psychosomatic medicine.

[6]  Joseph E. LeDoux,et al.  Emotion and the limbic system concept , 1991 .

[7]  O. Vinogradova.  Functional Organization of the Limbic System in the Process of Registration of Information: Facts and Hypotheses , 1975 .

[8]  Douglas L. Jones,et al.  From motivation to action: Functional interface between the limbic system and the motor system , 1980, Progress in Neurobiology.

[9]  L. Swanson,et al.  Structural Evidence for Functional Domains in the Rat Hippocampus , 1996, Science.

[10]  J. W. Papez.  A PROPOSED MECHANISM OF EMOTION , 1937 .

[11]  C. Keyes.  The triune brain in evolution: Role in paleocerebral functions: By Paul D. MacLean. New York: Plenum, 1990, xxiv + 672 pp , 1991 .

[12]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[13]  T. Dagi,et al.  Reformulation of the papez circuit: Absence of hippocampal influence on cingulate cortex unit activity in the primate , 1983, Brain Research.

[14]  G. E. Alexander,et al.  Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. , 1990, Progress in brain research.

[15]  Robert L. Isaacson,et al.  A fuzzy limbic system , 1992, Behavioural Brain Research.

[16]  L. Ciompi,et al.  Affects as Central Organising and Integrating Factors a New Psychosocial/Biological Model of the Psyche , 1991, British Journal of Psychiatry.

[17]  D von Cramon,et al.  [Disorders of learning and memory in focal cerebral tissue lesions]. , 1989, Fortschritte der Neurologie-Psychiatrie.

[18]  P. Levitt,et al.  A monoclonal antibody to limbic system neurons. , 1984, Science.

[19]  J. Herbert,et al.  Peptides in the limbic system: Neurochemical codes for co-ordinated adaptive responses to behavioural and physiological demand , 1993, Progress in Neurobiology.

[20]  K. Pribram,et al.  Neuronographic analysis of medial and basal cerebral cortex. II. Monkey. , 1953, Journal of neurophysiology.

[21]  P. Maclean.  Some psychiatric implications of physiological studies on frontotemporal portion of limbic system (visceral brain). , 1952, Electroencephalography and clinical neurophysiology.

[22]  R. Passingham.  The hippocampus as a cognitive map J. O'Keefe & L. Nadel, Oxford University Press, Oxford (1978). 570 pp., £25.00 , 1979, Neuroscience.

[23]  K. Livingston,et al.  The Experimental-Clinical Interface: Kindling as a Dynamic Model of Induced Limbic System Dysfunction , 1978 .

[24]  R. Kötter,et al.  The limbic system: a review of its empirical foundation , 1992, Behavioural Brain Research.

[25]  A. Meyer.  Historical aspects of cerebral anatomy , 1971 .

[26]  C R Olson,et al.  Organization of cortical and subcortical projections to anterior cingulate cortex in the cat , 1988, The Journal of comparative neurology.

[27]  Y. Hurd,et al.  Differential messenger RNA expression of prodynorphin and proenkephalin in the human brain , 1996, Neuroscience.

[28]  L. E. White,et al.  A morphologic concept of the limbic lobe. , 1965, International review of neurobiology.

[29]  Smith Ge,et al.  Natural Subdivision of the Cerebral Hemisphere. , 1901 .

[30]  S. Bayer,et al.  Development of the lateral and medial limbic cortices in the rat in relation to cortical phylogeny , 1990, Experimental Neurology.

[31]  W. Nauta,et al.  Hippocampal projections and related neural pathways to the midbrain in the cat. , 1958, Brain : a journal of neurology.

[32]  W. A. FORBES,et al.  The Cat , 2020, Nature.

[33]  F. H. Lopes da Silva,et al.  Anatomic organization and physiology of the limbic cortex. , 1990, Physiological reviews.