Locally E-optimal designs for expo-nential regression models

In this paper we investigate locally E- and c-optimal designs for exponential regression models of the form _k i=1 ai exp(??ix). We establish a numerical method for the construction of efficient and locally optimal designs, which is based on two results. First we consider the limit ?i ? ? and show that the optimal designs converge weakly to the optimal designs in a heteroscedastic polynomial regression model. It is then demonstrated that in this model the optimal designs can be easily determined by standard numerical software. Secondly, it is proved that the support points and weights of the locally optimal designs in the exponential regression model are analytic functions of the nonlinear parameters ?1, . . . , ?k. This result is used for the numerical calculation of the locally E-optimal designs by means of a Taylor expansion for any vector (?1, . . . , ?k). It is also demonstrated that in the models under consideration E-optimal designs are usually more efficient for estimating individual parameters than D-optimal designs.

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