Both eugenol and biseugenol treatments reduced lung alterations in an experimental model of elastase-induced pulmonary emphysema

[1]  S. Raha,et al.  Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses , 2021, Journal of Neuroimmune Pharmacology.

[2]  H. Tsukahara,et al.  Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease , 2021, Antioxidants.

[3]  M. Rafiq,et al.  Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review , 2021, Oxidative medicine and cellular longevity.

[4]  F. R. Santana,et al.  Effects of Eugenol and Dehydrodieugenol B from Nectandra leucantha against Lipopolysaccharide (LPS)-Induced Experimental Acute Lung Inflammation. , 2021, Journal of natural products.

[5]  J. Cortijo,et al.  Nitric Oxide System and Bronchial Epithelium: More Than a Barrier , 2021, Frontiers in Physiology.

[6]  M. P. Barros,et al.  Melatonin improves the antioxidant capacity in cardiac tissue of Wistar rats after exhaustive exercise , 2021, Free radical research.

[7]  H. Khan,et al.  Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[8]  C. Beisswenger,et al.  Preclinical studies and the function of IL-17 cytokines in COPD. , 2021, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[9]  Leina Ma,et al.  Eugenol protects cells against oxidative stress via Nrf2 , 2020, Experimental and therapeutic medicine.

[10]  F. R. Santana,et al.  Biseugenol Exhibited Anti-Inflammatory and Anti-Asthmatic Effects in an Asthma Mouse Model of Mixed-Granulocytic Asthma , 2020, Molecules.

[11]  J. Yodoi,et al.  Progress in the mechanism and targeted drug therapy for COPD , 2020, Signal Transduction and Targeted Therapy.

[12]  Francisco Das Chagas Pereira de Andrade,et al.  Computational analysis of eugenol inhibitory activity in lipoxygenase and cyclooxygenase pathways , 2020, Scientific Reports.

[13]  R. Righetti,et al.  Bronchial Vascular Remodeling Is Attenuated by Anti-IL-17 in Asthmatic Responses Exacerbated by LPS , 2020, Frontiers in Pharmacology.

[14]  D. Ribeiro,et al.  Dehydrodieugenol improved lung inflammation in an asthma model by inhibiting the STAT3/SOCS3 and MAPK pathways. , 2020, Biochemical pharmacology.

[15]  Jieyu Tian,et al.  Cigarette smoke‐induced HMGB1 translocation and release contribute to migration and NF‐κB activation through inducing autophagy in lung macrophages , 2019, Journal of cellular and molecular medicine.

[16]  Y. Bustanji,et al.  Eugenol Reduces LDL Cholesterol and Hepatic Steatosis in Hypercholesterolemic Rats by Modulating TRPV1 Receptor , 2019, Scientific Reports.

[17]  C. Brightling,et al.  Airway inflammation in COPD: progress to precision medicine , 2019, European Respiratory Journal.

[18]  M. Ansari,et al.  A novel Nanoformulation Development of Eugenol and their treatment in inflammation and periodontitis , 2019, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

[19]  X. Ci,et al.  Role of Nrf2 and Its Activators in Respiratory Diseases , 2019, Oxidative medicine and cellular longevity.

[20]  Ateeque Ahmad,et al.  Synthesis of eugenol derivatives and its anti-inflammatory activity against skin inflammation , 2018, Natural product research.

[21]  Francisco Noé da Fonseca,et al.  Eugenol as a Promising Molecule for the Treatment of Dermatitis: Antioxidant and Anti-inflammatory Activities and Its Nanoformulation , 2018, Oxidative medicine and cellular longevity.

[22]  O. Al‐Shabanah,et al.  Anti-metastatic and anti-proliferative activity of eugenol against triple negative and HER2 positive breast cancer cells , 2018, BMC Complementary and Alternative Medicine.

[23]  D. P. de Sousa,et al.  An Overview on the Anti-inflammatory Potential and Antioxidant Profile of Eugenol , 2018, Oxidative medicine and cellular longevity.

[24]  A. Agustí,et al.  Bone marrow characterization in COPD: a multi-level network analysis , 2018, Respiratory Research.

[25]  Liao FangJun,et al.  Tumor suppressive roles of eugenol in human lung cancer cells , 2017, Thoracic cancer.

[26]  Y. Murakami,et al.  Expression of Cyclooxygenase-2, Nitric Oxide Synthase 2 and Heme Oxygenase-1 mRNA Induced by Bis-Eugenol in RAW264.7 Cells and their Antioxidant Activity Determined Using the Induction Period Method. , 2017, In vivo.

[27]  G. Dale,et al.  The Role of Neutrophil Elastase Inhibitors in Lung Diseases. , 2017, Chest.

[28]  N. Başaran,et al.  Pharmacological and Toxicological Properties of Eugenol , 2017, Turkish journal of pharmaceutical sciences.

[29]  N. Câmara,et al.  Prophylactic and therapeutic treatment with the flavonone sakuranetin ameliorates LPS-induced acute lung injury. , 2017, American journal of physiology. Lung cellular and molecular physiology.

[30]  Cécile M. Bidan,et al.  Elastase-Induced Parenchymal Disruption and Airway Hyper Responsiveness in Mouse Precision Cut Lung Slices: Toward an Ex vivo COPD Model , 2017, Front. Physiol..

[31]  F. Lu,et al.  Differentiating parts of Cinnamomum cassia using LC-qTOF-MS in conjunction with principal component analysis. , 2016, Biomedical chromatography : BMC.

[32]  N. Câmara,et al.  A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases , 2015, Respiratory Research.

[33]  Chunhua Ma,et al.  Anti-inflammatory effects of eugenol on lipopolysaccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status. , 2015, International immunopharmacology.

[34]  A. Satoskar,et al.  Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha. , 2015, Journal of natural products.

[35]  E. Miyaji,et al.  Aerobic exercise attenuates pulmonary inflammation induced by Streptococcus pneumoniae. , 2014, Journal of applied physiology.

[36]  F. Stefanello,et al.  Eugenol derivatives as potential anti‐oxidants: is phenolic hydroxyl necessary to obtain an effect? , 2014, The Journal of pharmacy and pharmacology.

[37]  P. Barnes.  Cellular and molecular mechanisms of chronic obstructive pulmonary disease. , 2014, Clinics in chest medicine.

[38]  B. Suki,et al.  Emphysema and mechanical stress-induced lung remodeling. , 2013, Physiology.

[39]  Y. Wang,et al.  Effects of combined acupuncture and eugenol on learning-memory ability and antioxidation system of hippocampus in Alzheimer disease rats via olfactory system stimulation. , 2013, Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.

[40]  Moon‐Moo Kim,et al.  Eugenol with antioxidant activity inhibits MMP-9 related to metastasis in human fibrosarcoma cells. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[41]  Y. Murakami,et al.  Comparative inhibitory effects of magnolol, honokiol, eugenol and bis-eugenol on cyclooxygenase-2 expression and nuclear factor-kappa B activation in RAW264.7 macrophage-like cells stimulated with fimbriae of Porphyromonas gingivalis. , 2012, In vivo.

[42]  P. Saldiva,et al.  Eugenol attenuates pulmonary damage induced by diesel exhaust particles. , 2012, Journal of applied physiology.

[43]  P. Rocco,et al.  Elastase-induced pulmonary emphysema: insights from experimental models. , 2011, Anais da Academia Brasileira de Ciencias.

[44]  I. Gülçin.  Antioxidant activity of eugenol: a structure-activity relationship study. , 2011, Journal of medicinal food.

[45]  I. Chen,et al.  Eugenolol and Glyceryl-Isoeugenol Suppress LPS-Induced INOS Expression by Down-Regulating NF-κB and AP-1 through Inhibition of Mapks and AKT/IκBα Signaling Pathways in Macrophages , 2011, International journal of immunopathology and pharmacology.

[46]  R. S. Murugan,et al.  Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. , 2010, Life sciences.

[47]  W. Zin,et al.  In vivo anti-inflammatory action of eugenol on lipopolysaccharide-induced lung injury. , 2010, Journal of applied physiology.

[48]  F. C. Sampaio,et al.  Estudo toxicológico pré-clínico (agudo) do extrato do Syzygium aromaticum (L) em roedores , 2009 .

[49]  P. Calverley,et al.  Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. , 2008, American journal of respiratory and critical care medicine.

[50]  K. Yoshiura,et al.  Sequential and quantitative analysis of a murine model of elastase-induced emphysema. , 2008, Biological & pharmaceutical bulletin.

[51]  M. Martins,et al.  Effects of chronic L-NAME treatment lung tissue mechanics, eosinophilic and extracellular matrix responses induced by chronic pulmonary inflammation. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[52]  A. Chung,et al.  Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kappaB activation. , 2006, Carcinogenesis.

[53]  J. Zubeldia,et al.  Inhibition of Chronic Airway Inflammation and Remodeling by Galectin-3 Gene Therapy in a Murine Model1 , 2006, The Journal of Immunology.

[54]  J. McCord,et al.  SOD, oxidative stress and human pathologies: a brief history and a future vision. , 2005, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[55]  Y. Murakami,et al.  Dehydrodiisoeugenol, an isoeugenol dimer, inhibits lipopolysaccharide-stimulated nuclear factor kappa B activation and cyclooxygenase-2 expression in macrophages. , 2005, Archives of biochemistry and biophysics.

[56]  X. Busquets,et al.  NF-κB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight , 2004, Thorax.

[57]  O. Erel,et al.  A novel automated method to measure total antioxidant response against potent free radical reactions. , 2004, Clinical biochemistry.

[58]  Y. Murakami,et al.  Preventive effect of bis-eugenol, a eugenol ortho dimer, on lipopolysaccharide-stimulated nuclear factor kappa B activation and inflammatory cytokine expression in macrophages. , 2003, Biochemical pharmacology.

[59]  S. Urano,et al.  Antioxidant activity of eugenol and related monomeric and dimeric compounds. , 2000, Chemical & pharmaceutical bulletin.

[60]  K. Oka,et al.  Impact of free magnolol excretions in asthmatic patients who responded well to Saiboku‐To, a Chinese herbal medicine , 1993, The Journal of pharmacy and pharmacology.

[61]  K. Oka,et al.  Suppression of mitogen-induced proliferation of human peripheral blood lymphocytes by plant lignans. , 1991, Planta medica.

[62]  S. Barman,et al.  Galectin-3 Promotes ROS, Inflammation, and Vascular Fibrosis in Pulmonary Arterial Hypertension. , 2021, Advances in experimental medicine and biology.

[63]  B. Suki,et al.  Elastase-Induced Lung Emphysema Models in Mice. , 2017, Methods in molecular biology.

[64]  Y. Murakami,et al.  Eugenol and Its Role in Chronic Diseases. , 2016, Advances in experimental medicine and biology.