Proteomic approach to studying parkinson’s disease
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[1] Janel O. Johnson,et al. α-Synuclein Locus Triplication Causes Parkinson's Disease , 2003, Science.
[2] Jeffrey H. Kordower,et al. The role of α-synuclein in Parkinson's disease: insights from animal models , 2003, Nature Reviews Neuroscience.
[3] V. Buchman,et al. Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease , 2003, Neuropharmacology.
[4] T. Flotte,et al. A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[5] A. Björklund,et al. Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[6] Matthew P Frosch,et al. The Formation of Highly Soluble Oligomers of α-Synuclein Is Regulated by Fatty Acids and Enhanced in Parkinson's Disease , 2003, Neuron.
[7] C. Warren Olanow,et al. Altered Proteasomal Function in Sporadic Parkinson's Disease , 2003, Experimental Neurology.
[8] Todd B. Sherer,et al. Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation , 2003, Experimental Neurology.
[9] T. Dawson,et al. Rare genetic mutations shed light on the pathogenesis of Parkinson disease. , 2003, The Journal of clinical investigation.
[10] K. Davies,et al. Ubiquitin Conjugation Is Not Required for the Degradation of Oxidized Proteins by Proteasome* , 2003, The Journal of Biological Chemistry.
[11] Smita Patel,et al. Golgi Fragmentation Occurs in the Cells with Prefibrillar α-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion* , 2002, The Journal of Biological Chemistry.
[12] B. Bioulac,et al. A ‘single toxin–double lesion’ rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis , 2002, Neuroscience.
[13] S. Totterdell,et al. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson’s disease , 2002, Brain Research.
[14] Hideo Fujiwara,et al. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. , 2002, The Journal of clinical investigation.
[15] P. Auluck,et al. Pharmacological prevention of Parkinson disease in Drosophila , 2002, Nature Medicine.
[16] M. Waterfield,et al. Identification of novel candidates for replicative senescence by functional proteomics , 2002, Oncogene.
[17] Robert Burke,et al. Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[18] J. Trojanowski,et al. Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses. , 2002, Neurotoxicology.
[19] Makoto Hashimoto,et al. Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein. , 2002, Neurotoxicology.
[20] G. Cohen,et al. Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro * , 2002, The Journal of Biological Chemistry.
[21] D. Butterfield,et al. Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase‐related protein 2, α‐enolase and heat shock cognate 71 , 2002, Journal of neurochemistry.
[22] P. Werner,et al. Selective destruction of dopaminergic neurons by low concentrations of 6-OHDA and MPP+: protection by acetylsalicylic acid aspirin. , 2002, Parkinsonism & related disorders.
[23] Todd B. Sherer,et al. An In Vitro Model of Parkinson's Disease: Linking Mitochondrial Impairment to Altered α-Synuclein Metabolism and Oxidative Damage , 2002, The Journal of Neuroscience.
[24] C. Olanow,et al. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats , 2002, Neuroreport.
[25] M. Mann,et al. Large-scale Proteomic Analysis of the Human Spliceosome References , 2006 .
[26] L. Millen,et al. Conformational Remodeling of Proteasomal Substrates by PA700, the 19 S Regulatory Complex of the 26 S Proteasome* , 2002, The Journal of Biological Chemistry.
[27] P. Lansbury,et al. Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes. , 2002, Biochemistry.
[28] Johannes Schwarz,et al. Expression of mutant &agr;-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro , 2002, Neuroreport.
[29] C. Olanow,et al. Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease , 2002, Neuroscience Letters.
[30] T. Montine,et al. Mitochondrial DNA Deletions/Rearrangements in Parkinson Disease and Related Neurodegenerative Disorders , 2002, Journal of neuropathology and experimental neurology.
[31] B. Cravatt,et al. Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype , 2002, Nature Biotechnology.
[32] Nancy A. Jenkins,et al. Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[33] I. Ziv,et al. Mutant and wild-type α-synuclein interact with mitochondrial cytochrome C oxidase , 2002, Journal of Molecular Neuroscience.
[34] J. Trojanowski,et al. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. , 2002, Free radical biology & medicine.
[35] M. Barrachina,et al. MPP+ increases α-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells , 2002, Brain Research.
[36] B. Hyman,et al. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. , 2002, The American journal of pathology.
[37] C. Dobson,et al. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases , 2002, Nature.
[38] A. Björklund,et al. Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System , 2002, The Journal of Neuroscience.
[39] Rajesh Pahwa,et al. Age at onset in two common neurodegenerative diseases is genetically controlled. , 2002, American journal of human genetics.
[40] Mary F. Lopez,et al. Applied proteomics: mitochondrial proteins and effect on function. , 2002, Circulation research.
[41] Chung-Soo Lee,et al. Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells , 2002, Neurochemistry International.
[42] S. Shin,et al. Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors* , 2002, The Journal of Biological Chemistry.
[43] Hanno Langen,et al. The rat liver mitochondrial proteins , 2002, Electrophoresis.
[44] D. Goodlett,et al. Proteomics without polyacrylamide: qualitative and quantitative uses of tandem mass spectrometry in proteome analysis , 2002, Functional & Integrative Genomics.
[45] R. Roth,et al. Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP‐treated monkeys: Feasibility relevant to multiple‐target grafting as a therapy for Parkinson's disease , 2002, The Journal of comparative neurology.
[46] J. Growdon,et al. Epidemiologic study of 203 sibling pairs with Parkinson’s disease , 2002, Neurology.
[47] Shihua Li,et al. Chaperone Suppression of Cellular Toxicity of Huntingtin Is Independent of Polyglutamine Aggregation* , 2001, The Journal of Biological Chemistry.
[48] John Q. Trojanowski,et al. Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease , 2001, Science.
[49] E. Melamed,et al. 6-Hydroxydopamine Increases Ubiquitin-Conjugates and Protein Degradation: Implications for the Pathogenesis of Parkinson's Disease , 2001, Cellular and Molecular Neurobiology.
[50] J. Smeitink,et al. Mitochondrial oxidative phosphorylation system assembly in man: recent achievements , 2001, Current opinion in neurology.
[51] D. Sulzer. α-synuclein and cytosolic dopamine: Stabilizing a bad situation , 2001, Nature Medicine.
[52] M. Spillantini,et al. α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome , 2001, FEBS letters.
[53] David Blum,et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease , 2001, Progress in Neurobiology.
[54] K. Davies,et al. Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells , 2001, Cellular and Molecular Life Sciences CMLS.
[55] J. Bergquist,et al. Identification of nuclei associated proteins by 2D-gel electrophoresis and mass spectrometry , 2001, Journal of Neuroscience Methods.
[56] B. Friguet,et al. Oxidative Modification and Inactivation of the Proteasome during Coronary Occlusion/Reperfusion* , 2001, The Journal of Biological Chemistry.
[57] Barry Halliwell,et al. Failure of the ubiquitin–proteasome system in Parkinson's disease , 2001, Nature Reviews Neuroscience.
[58] R. Aebersold,et al. Differential stable isotope labeling of peptides for quantitation and de novo sequence derivation. , 2001, Rapid communications in mass spectrometry : RCM.
[59] Nobutaka Hattori,et al. Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease , 2001, Science.
[60] P. Lansbury,et al. Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. , 2001, Biochemistry.
[61] David M. Smith,et al. Ester Bond-containing Tea Polyphenols Potently Inhibit Proteasome Activity in Vitro and in Vivo * , 2001, The Journal of Biological Chemistry.
[62] C. Ross,et al. Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. , 2001, Human molecular genetics.
[63] B. Chait,et al. Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome , 2001, Nature Biotechnology.
[64] K. Davies. Degradation of oxidized proteins by the 20S proteasome. , 2001, Biochimie.
[65] M. Vu,et al. Proteasomes Modulate Balance Among Proapoptotic and Antiapoptotic Bcl-2 Family Members and Compromise Functioning of the Electron Transport Chain in Leukemic Cells1 , 2001, The Journal of Immunology.
[66] R. Aebersold,et al. Mass spectrometry in proteomics. , 2001, Chemical reviews.
[67] K. McNaught,et al. Proteasomal function is impaired in substantia nigra in Parkinson's disease , 2001, Neuroscience Letters.
[68] F. Dabbeni-sala,et al. Melatonin protects against 6‐OHDA‐induced neurotoxicity in rats: a role for mitochondrial complex I activity , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[69] Virginia M. Y. Lee,et al. Oxidative post‐translational modifications of α‐synuclein in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model of Parkinson's disease , 2001, Journal of neurochemistry.
[70] J. Trojanowski,et al. “Fatal Attractions” of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders , 2000, Annals of the New York Academy of Sciences.
[71] Todd B. Sherer,et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.
[72] P. Riederer,et al. Crosslinking of α-synuclein by advanced glycation endproducts — an early pathophysiological step in Lewy body formation? , 2000, Journal of Chemical Neuroanatomy.
[73] J. Trojanowski,et al. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. , 2000, Science.
[74] Andrew P. VanDemark,et al. Opening doors into the proteasome , 2000, Nature Structural Biology.
[75] A. Goldberg,et al. PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone , 2000, Nature Cell Biology.
[76] Mauro Fasano,et al. Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson’s disease patients are consistent with protein aggregation , 2000, Neurochemistry International.
[77] S. Gygi,et al. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[78] J. Trojanowski,et al. Neurodegeneration with Brain Iron Accumulation, Type 1 Is Characterized by α-, β-, and γ-Synuclein Neuropathology , 2000 .
[79] A. Davies,et al. Induction of neuronal death by α‐synuclein , 2000, The European journal of neuroscience.
[80] E. Masliah,et al. α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress , 2000 .
[81] R. Jansen. Origin and persistence of the mitochondrial genome. , 2000, Human reproduction.
[82] P. Lansbury,et al. Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson’s disease? , 2000, Nature Cell Biology.
[83] B. Giasson,et al. Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. , 2000, The Journal of biological chemistry.
[84] G. Kroemer,et al. Simplification of complex peptide mixtures for proteomic analysis: Reversible biotinylation of cysteinyl peptides , 2000, Electrophoresis.
[85] P. Gluckman,et al. N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats , 2000, Brain Research.
[86] W. Bender,et al. A Drosophila model of Parkinson's disease , 2000, Nature.
[87] M. Mostert,et al. Structural and functional characterization of 20S and 26S proteasomes from bovine brain. , 2000, Brain research. Molecular brain research.
[88] T. Montine,et al. Enhancement of Dopaminergic Neurotoxicity by the Mercapturate of Dopamine , 2000, Journal of neurochemistry.
[89] B. Chait,et al. The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism , 2000 .
[90] L. Mucke,et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. , 2000, Science.
[91] K. Marder,et al. Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson’s disease , 2000, Neurology.
[92] G. Kroemer,et al. Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition , 2000, Cell Death and Differentiation.
[93] M. Vila,et al. α‐Synuclein Up‐Regulation in Substantia Nigra Dopaminergic Neurons Following Administration of the Parkinsonian Toxin MPTP , 2000, Journal of neurochemistry.
[94] R. Mandel. Effect of Acute l -Dopa Pretreatment on Apomorphine-Induced Rotational Behavior in a Rat Model of Parkinson's Disease , 2000, Experimental Neurology.
[95] Heidi Phillips,et al. Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System , 2000, Neuron.
[96] Philippe Hantraye,et al. MPTP induces alpha‐synuclein aggregation in the substantia nigra of baboons , 2000, Neuroreport.
[97] R. Roth,et al. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment , 1999, Neuroscience.
[98] S. Gygi,et al. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags , 1999, Nature Biotechnology.
[99] C. Slaughter,et al. The Proteasome, a Novel Protease Regulated by Multiple Mechanisms* , 1999, The Journal of Biological Chemistry.
[100] J. Yates,et al. Direct analysis of protein complexes using mass spectrometry , 1999, Nature Biotechnology.
[101] T. Montine,et al. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. , 1999, The American journal of pathology.
[102] A. Fink. Chaperone-mediated protein folding. , 1999, Physiological reviews.
[103] Erwan Bezard,et al. Absence of MPTP-Induced Neuronal Death in Mice Lacking the Dopamine Transporter , 1999, Experimental Neurology.
[104] R. Kopito,et al. Aggresomes: A Cellular Response to Misfolded Proteins , 1998, The Journal of cell biology.
[105] M. Bolotin-Fukuhara,et al. A mutation in a novel yeast proteasomal gene, RPN11/MPR1, produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA, and an altered mitochondrial morphology. , 1998, Molecular biology of the cell.
[106] Georg Auburger,et al. The ubiquitin pathway in Parkinson's disease , 1998, Nature.
[107] M. Polymeropoulos. Autosomal dominant Parkinson’s disease , 1998, Journal of Neurology.
[108] J Q Trojanowski,et al. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein , 1998, Annals of neurology.
[109] J. Langston,et al. Epidemiology versus genetics in parkinson's disease: Progress in resolving an age‐old debate , 1998, Annals of neurology.
[110] P. Jenner,et al. Understanding cell death in parkinson's disease , 1998, Annals of neurology.
[111] Langston Jw. Epidemiology versus genetics in parkinson's disease: Progress in resolving an age-old debate , 1998 .
[112] K. Tipton,et al. Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine. , 1998, European Journal of Pharmacology.
[113] W. Welch,et al. Neurodegeneration: Chaperoning brain diseases , 1998, Nature.
[114] T. Montine,et al. Neurotoxicity of Endogenous Cysteinylcatechols , 1997, Experimental Neurology.
[115] G. Dryhurst,et al. Irreversible Inhibition of Mitochondrial Complex I by 7‐(2‐Aminoethyl)‐3,4‐Dihydro‐5‐Hydroxy‐2H‐1,4‐Benzothiazine‐3‐Carboxylic Acid (DHBT‐1): A Putative Nigral Endotoxin of Relevance to Parkinson's Disease , 1997, Journal of neurochemistry.
[116] D. D. Di Monte,et al. Inhibition of Monoamine Oxidase Contributes to the Protective Effect of 7‐Nitroindazole Against MPTP Neurotoxicity , 1997, Journal of neurochemistry.
[117] A. Lees,et al. A Generalised Increase in Protein Carbonyls in the Brain in Parkinson's but Not Incidental Lewy Body Disease , 1997, Journal of neurochemistry.
[118] Robert L. Nussbaum,et al. Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease , 1997 .
[119] M. Boyd,et al. Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice , 1997, Brain Research.
[120] K. Hoyt,et al. Mechanisms of Dopamine-Induced Cell Death in Cultured Rat Forebrain Neurons: Interactions with and Differences from Glutamate-Induced Cell Death , 1997, Experimental Neurology.
[121] K. Kosaka,et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB) , 1996, Neurology.
[122] R. Swerdlow,et al. Origin and functional consequences of the complex I defect in Parkinson's disease , 1996, Annals of neurology.
[123] Xiaodong Wang,et al. Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c , 1996, Cell.
[124] N. Hattori,et al. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[125] J. Cano,et al. Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine , 1995, Human & experimental toxicology.
[126] M. Beal,et al. Aging, energy, and oxidative stress in neurodegenerative diseases , 1995, Annals of neurology.
[127] Robert Hill,et al. Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease , 1995, Annals of neurology.
[128] C. L. Li,et al. Lipid peroxidation in brain: interactions of L-DOPA/dopamine with ascorbate and iron. , 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.
[129] E. Montgomery. Heavy metals and the etiology of Parkinson's disease and other movement disorders. , 1995, Toxicology.
[130] R. Bartrons,et al. Cerebrospinal dopamine metabolites in rats after intrastriatal administration of 6-hydroxydopamine or 1-methyl-4-phenylpyridinium ion , 1995, Brain Research.
[131] D. Murphy,et al. In Vivo Generation of Hydroxyl Radicals and MPTP‐Induced Dopaminergic Toxicity in the Basal Ganglia , 1994, Annals of the New York Academy of Sciences.
[132] K. H. White,et al. Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue. , 1994, Molecular biology of the cell.
[133] V. Bergdall,et al. Effects of Nerve Growth Factor Infusion on Behavioral Recovery and Graft Survival Following Intraventricular Adrenal Medulla Grafts in the Unilateral 6-Hydroxydopamine Lesioned Rat , 1994, Journal of neural transplantation & plasticity.
[134] A. Zuddas,et al. In Brown Norway Rats, MPP+ Is Accumulated in the Nigrostriatal Dopaminergic Terminals but It Is Not Neurotoxic: A Model of Natural Resistance to MPTP Toxicity , 1994, Experimental Neurology.
[135] R. Benecke,et al. Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes. , 1993, Brain : a journal of neurology.
[136] T. Haystead,et al. Gamma-phosphate-linked ATP-sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase. , 1993, European journal of biochemistry.
[137] C. Piantadosi,et al. Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. , 1992, The Journal of clinical investigation.
[138] B. Chait,et al. Weighing naked proteins: practical, high-accuracy mass measurement of peptides and proteins. , 1992, Science.
[139] D. Wallace. Mitochondrial genetics: a paradigm for aging and degenerative diseases? , 1992, Science.
[140] E. Abercrombie,et al. Neurochemical Responses to 6‐Hydroxydopamine and L‐Dopa Therapy: Implications for Parkinson's Disease a , 1992, Annals of the New York Academy of Sciences.
[141] M. Beal,et al. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? , 1992, Annals of neurology.
[142] K. Takeshige,et al. 1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles. , 1990, Biochemical and biophysical research communications.
[143] S. Ohta,et al. Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease , 1990, Journal of the Neurological Sciences.
[144] C. Marsden,et al. Mitochondrial Complex I Deficiency in Parkinson's Disease , 1990, Lancet.
[145] C. Altar,et al. 1-Methyl-4-phenylpyridine (MPP+): regional dopamine neuron uptake, toxicity, and novel rotational behavior following dopamine receptor proliferation. , 1986, European journal of pharmacology.
[146] R. Duvoisin,et al. Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity , 1985, Neuroscience Letters.
[147] C. Rebert,et al. Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey , 1984, Brain Research.
[148] J. Langston,et al. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. , 1983, Science.
[149] J. LaManna,et al. Abnormalities of cerebral oxidative metabolism in animal models of Parkinson disease , 1982, Neurology.
[150] B. Sahakian,et al. Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA , 1980, Pharmacology Biochemistry and Behavior.
[151] D. Graham. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. , 1978, Molecular pharmacology.
[152] D. Graham,et al. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. , 1978, Molecular pharmacology.
[153] B Chance,et al. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. , 1973, The Biochemical journal.
[154] G. Cohen,et al. In vivo generation of hydrogen peroxide from 6-hydroxydopamine , 1972, Experientia.
[155] U. Ungerstedt,et al. Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. , 1971, Acta physiologica Scandinavica. Supplementum.
[156] H. Thoenen,et al. Model experiments on the molecular mechanism of action of 6-hydroxydopamine. , 1971, Molecular pharmacology.
[157] C. Chiueh,et al. In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+ , 2005, Journal of Neural Transmission / General Section JNT.
[158] P. Riederer,et al. Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man , 2005, Journal of Neural Transmission.
[159] Jeffrey H Kordower,et al. The role of alpha-synuclein in Parkinson's disease: insights from animal models. , 2003, Nature reviews. Neuroscience.
[160] V. Buchman,et al. Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease. , 2003, Neuropharmacology.
[161] A. Schapira,et al. Genetic and environmental factors in the cause of Parkinson's disease , 2003, Annals of neurology.
[162] J. Trojanowski,et al. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. , 2002, Science.
[163] M. Barrachina,et al. MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. , 2002, Brain research.
[164] I. Ziv,et al. Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase. , 2002, Journal of molecular neuroscience : MN.
[165] J. Trojanowski,et al. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. , 2002, The Journal of clinical investigation.
[166] T. Montine,et al. The mitochondrial common deletion in Parkinson's disease and related movement disorders. , 2002, Parkinsonism & related disorders.
[167] K. Jellinger,et al. Recent developments in the pathology of Parkinson's disease. , 2002, Journal of neural transmission. Supplementum.
[168] D. Price,et al. Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[169] W. Dröge. Free radicals in the physiological control of cell function. , 2002, Physiological reviews.
[170] D. Sulzer,et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. , 2000, Neuron.
[171] J. Brosens,et al. Redefining endometriosis: is deep endometriosis a progressive disease? , 2000, Human reproduction.
[172] M. Beal,et al. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease , 1999, BioFactors.
[173] W. Baumeister,et al. The 26S proteasome: a molecular machine designed for controlled proteolysis. , 1999, Annual review of biochemistry.
[174] R. Krüger,et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. , 1998, Nature genetics.
[175] S E Ide,et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. , 1997, Science.
[176] K. Jellinger,et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. , 1996, Neurology.
[177] J. Langston,et al. Similarities and differences between MPTP-induced parkinsonsim and Parkinson's disease. Neuropathologic considerations. , 1993, Advances in neurology.
[178] M. Okada,et al. Central depletion of dopamine in rats by 1-methyl-4-phenylpyridine. , 1989, Life sciences.
[179] G. Cohen. Monoamine oxidase, hydrogen peroxide, and Parkinson's disease. , 1987, Advances in neurology.
[180] G. Cohen. The pathobiology of Parkinson's disease: biochemical aspects of dopamine neuron senescence. , 1983, Journal of neural transmission. Supplementum.
[181] B. Steinmann,et al. Mass fragmentography of dopamine and 6-hydroxydopamine. Application to the determination of dopamine in human brain biopsies from the caudate nucleus. , 1974, Journal of chromatography.
[182] Yeast Yeast 2000; 17: 81±87. Review Article , 2022 .