Cytokine modulation in acute pancreatitis.

[1]  J. Neoptolemos,et al.  Treatment with neutralising antibody against cytokine induced neutrophil chemoattractant (CINC) protects rats against acute pancreatitis associated lung injury , 2000, Gut.

[2]  E. Livingston,et al.  Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. , 2000, American journal of physiology. Cell physiology.

[3]  H. Friess,et al.  Acute Necrotizing Pancreatitis: Treatment Strategy According to the Status of Infection , 2000, Annals of surgery.

[4]  K. Fearon,et al.  Randomized controlled trial of the effect of early enteral nutrition on markers of the inflammatory response in predicted severe acute pancreatitis , 2000, The British journal of surgery.

[5]  S. Pandol,et al.  Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells. , 2000, American journal of physiology. Gastrointestinal and liver physiology.

[6]  F. Gansauge,et al.  Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications , 2000, Gut.

[7]  J. Dagorn,et al.  Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation. , 2000, Gastroenterology.

[8]  Jun Yang,et al.  Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome. , 2000, Surgery.

[9]  M. Ogawa,et al.  Relationship Between Plasma Cytokine Concentration and Multiple Organ Failure in Patients with Acute Pancreatitis , 2000, Pancreas.

[10]  K. Tracey,et al.  Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome , 2000, Critical care medicine.

[11]  A. Andoh,et al.  Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. , 2000, Gastroenterology.

[12]  C. Murdoch,et al.  Chemokine receptors and their role in inflammation and infectious diseases. , 2000, Blood.

[13]  M. Kotb,et al.  Temporal correlation of tumor necrosis factor-alpha release, upregulation of pulmonary ICAM-1 and VCAM-1, neutrophil sequestration, and lung injury in diet-induced pancreatitis , 2000, Journal of Gastrointestinal Surgery.

[14]  A. Demaine,et al.  Investigation of the Interleukin 1 Gene Cluster and Its Association with Acute Pancreatitis , 2000, Pancreas.

[15]  M. Kotb,et al.  Quantitative measurement of P- and E-selectin adhesion molecules in acute pancreatitis: correlation with distant organ injury. , 2000, Annals of surgery.

[16]  J. Neoptolemos,et al.  Inflammatory mediators in acute pancreatitis , 2000, The Journal of pathology.

[17]  B. Han,et al.  CCK stimulates mob-1 expression and NF-κB activation via protein kinase C and intracellular Ca2+ , 2000 .

[18]  M. Mayo,et al.  Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding* , 1999, The Journal of Biological Chemistry.

[19]  S. L. Jensen,et al.  Acute Pancreatitis: The Pathophysiological Role of Cytokines and Integrins , 1999, Digestive Surgery.

[20]  A. Hoeft,et al.  Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. , 1999, Critical care medicine.

[21]  B. Rau,et al.  Systemic lymphocyte activation modulates the severity of diet-induced acute pancreatitis in mice. , 1999, Pancreas.

[22]  P. Galanaud,et al.  Pro- and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response, although unpredictable of death. Parisian Study Group on Acute Pancreatitis. , 1999, Critical care medicine.

[23]  A. Saluja,et al.  The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury. , 1999, Gastroenterology.

[24]  A. Masamune,et al.  Inhibition of nuclear factor-κB activation improves the survival of rats with taurocholate pancreatitis , 1999, Gut.

[25]  M. Grisham NF-kappaB activation in acute pancreatitis: protective, detrimental, or inconsequential? , 1999, Gastroenterology.

[26]  J. Yamauchi,et al.  A Novel Diamino-Pyridine Derivative Prevents Excessive Leukocyte Infiltration in Aggravation of Acute Necrotizing Pancreatitis , 1999, Digestion.

[27]  B. Göke,et al.  p38 Map Kinase Is Expressed in the Pancreas and Is Immediately Activated following Cerulein Hyperstimulation , 1999, Digestion.

[28]  S. Pandol,et al.  Early NF-κB activation is associated with hormone-induced pancreatitis. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[29]  H. Reber,et al.  Mechanism of increased lung injury after acute pancreatitis in IL-10 knockout mice. , 1998, The Journal of surgical research.

[30]  J. Grendell,et al.  Codistribution of TAP and the granule membrane protein GRAMP-92 in rat caerulein-induced pancreatitis. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[31]  George Kollias,et al.  A Critical Role of the p75 Tumor Necrosis Factor Receptor (p75TNF-R) in Organ Inflammation Independent of  TNF, Lymphotoxin α, or the p55TNF-R , 1998, The Journal of experimental medicine.

[32]  A. Saluja,et al.  The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury , 1998, International journal of pancreatology : official journal of the International Association of Pancreatology.

[33]  S. Ross,et al.  A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini* , 1998, The Journal of Biological Chemistry.

[34]  A. Straumann,et al.  Acute pancreatitis due to pyritinol: an immune-mediated phenomenon. , 1998, Gastroenterology.

[35]  M. Lerch,et al.  Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[36]  J. Neoptolemos,et al.  Acute pancreatitis: the substantial human and financial costs , 1998, Gut.

[37]  D. Heresbach,et al.  Value of early blood Th-1 cytokine determination in predicting severity of acute pancreatitis. , 1998, Scandinavian journal of gastroenterology.

[38]  L. Lozonschi,et al.  Criteria for diagnosis of acute pancreatitis in Japan and clinical implications. , 1998, Pancreas.

[39]  Jun Yang,et al.  TNF but not IL-1 decreases pancreatic acinar cell survival without affecting exocrine function: a study in the perfused human pancreas. , 1998, The Journal of surgical research.

[40]  J. Norman The role of cytokines in the pathogenesis of acute pancreatitis. , 1998, American journal of surgery.

[41]  G. Fink,et al.  Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis. , 1997, Cytokine.

[42]  R. Kao,et al.  Therapeutic modification of nuclear factor kappa B binding activity and tumor necrosis factor-alpha gene expression during acute biliary pancreatitis. , 1997, The American surgeon.

[43]  C. Logsdon,et al.  Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. , 1997, Gastroenterology.

[44]  G. Steinbach,et al.  The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis , 1997, Gut.

[45]  G. Carter,et al.  Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. , 1997, Gastroenterology.

[46]  A. Saluja,et al.  Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. , 1997, The Journal of clinical investigation.

[47]  S. Pandol,et al.  Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis. , 1997, The Journal of clinical investigation.

[48]  Jun Yang,et al.  Evidence for an unknown component of pancreatic ascites that induces adult respiratory distress syndrome through an interleukin-1 and tumor necrosis factor-dependent mechanism. , 1997, Surgery.

[49]  S. Opal,et al.  Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. , 1997, Critical care medicine.

[50]  H. Bruining,et al.  p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. , 1997, JAMA.

[51]  S. Ashley,et al.  Interleukin 10 reduces the severity of acute pancreatitis in rats. , 1997, Gastroenterology.

[52]  D. Livingston,et al.  Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). , 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[53]  T. Inagaki,et al.  Interleukin‐6 Is a Useful Marker for Early Prediction of the Severity of Acute Pancreatitis , 1997, Pancreas.

[54]  A. Kingsnorth Role of cytokines and their inhibitors in acute pancreatitis. , 1997, Gut.

[55]  G. Matuschak Circulating cytokine concentrations and outcome prediction in intensive care unit patients: still the tip of the iceberg? , 1996, Critical care medicine.

[56]  E. Moore,et al.  Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? , 1996, Annals of surgery.

[57]  D. Aderka The potential biological and clinical significance of the soluble tumor necrosis factor receptors. , 1996, Cytokine & growth factor reviews.

[58]  M. Franz,et al.  Timing of tumor necrosis factor antagonism is critical in determining outcome in murine lethal acute pancreatitis. , 1996, Surgery.

[59]  J. Carlet,et al.  INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. , 1996, Critical care medicine.

[60]  K. Fearon,et al.  Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis , 1996, The British journal of surgery.

[61]  S. Ashley,et al.  Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. , 1996, Surgery.

[62]  C. McKay,et al.  Increased monocyte cytokine production in association with systemic complications in acute pancreatitis , 1996, The British journal of surgery.

[63]  M. Kotb,et al.  Calcium Channel Blockade Inhibits Release of TNFα and Improves Survival in a Rat Model of Acute Pancreatitis , 1996, Pancreas.

[64]  S. Opal,et al.  Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. , 1996, The New England journal of medicine.

[65]  G. Fink,et al.  Intrapancreatic interleukin-1beta gene expression by specific leukocyte populations during acute pancreatitis. , 1996, The Journal of surgical research.

[66]  F. Stüber,et al.  A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. , 1996, Critical care medicine.

[67]  J. Ross,et al.  Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis , 1996, The British journal of surgery.

[68]  K. Collins,et al.  Decreased interleukin-2 production in murine acute pancreatitis: potential for immunomodulation. , 1996, Gastroenterology.

[69]  M. Kotb,et al.  Anti-TNFalpha therapy improves survival and ameliorates the pathophysiologic sequelae in acute pancreatitis in the rat. , 1996, American journal of surgery.

[70]  H. Reber,et al.  Cytokines and acute pancreatitis. , 1996, Gastroenterology.

[71]  M. Kotb,et al.  Inhibition of TNFα improves survival in an experimental model of acute pancreatitis , 1996 .

[72]  M. Kotb,et al.  Up-regulation of TNFα mRNA in the rat spleen following induction of acute pancreatitis , 1995 .

[73]  P. Montravers,et al.  Lymphatic release of cytokines during acute lung injury complicating severe pancreatitis. , 1995, American journal of respiratory and critical care medicine.

[74]  L. Formela,et al.  Randomized, double‐blind phase II trial of Lexipafant, a platelet‐activating factor antagonist, in human acute pancreatitis , 1995, The British journal of surgery.

[75]  M. Franz,et al.  Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. , 1995, Archives of surgery.

[76]  S. Akira,et al.  Interleukin-6 family of cytokines and gp130. , 1995, Blood.

[77]  P. Fabri,et al.  Decreased Mortality of Severe Acute Pancreatitis After Proximal Cytokine Blockade , 1995, Annals of surgery.

[78]  K. Miyazono,et al.  Localization of transforming growth factor β1 and its latent binding protein in human chronic pancreatitis , 1995 .

[79]  P. Fabri,et al.  Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. , 1995, Surgery.

[80]  N. Matsuura,et al.  Interleukin-1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model. , 1995, Critical care medicine.

[81]  G. Koch,et al.  Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial , 1995 .

[82]  S. Nasraway,et al.  Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. , 1995, JAMA.

[83]  M. Baggiolini,et al.  Interleukin-8 and the chemokine family. , 1995, International journal of immunopharmacology.

[84]  M. Kotb,et al.  Induction of acute pancreatitis in germ-free rats: evidence of a primary role for tumor necrosis factor-alpha. , 1995, Surgery.

[85]  L. Formela,et al.  Inflammatory mediators in acute pancreatitis , 1995, The British journal of surgery.

[86]  K. Washington,et al.  Pathology of the pancreas in severe combined immunodeficiency and DiGeorge syndrome: acute graft-versus-host disease and unusual viral infections. , 1994, Human pathology.

[87]  S. Opal,et al.  Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. , 1994, JAMA.

[88]  A. Gaber,et al.  Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage. , 1994, Surgery.

[89]  L. Gullo,et al.  Behavior of serum soluble interleukin-2 receptor, soluble CD8 and soluble CD4 in the early phases of acute pancreatitis. , 1994, Digestion.

[90]  M. Kotb,et al.  Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF-alpha polyclonal antibody. , 1994, American journal of surgery.

[91]  J. Schölmerich,et al.  Inflammatory mediators and cytokines--new aspects of the pathophysiology and assessment of severity of acute pancreatitis? , 1993, Hepato-gastroenterology.

[92]  T. Wirth,et al.  Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation , 1993, Nature.

[93]  K. Usadel,et al.  Arterial constriction, ischemia-reperfusion, and leukocyte adherence in acute pancreatitis. , 1993, The American journal of physiology.

[94]  A. Shenkin,et al.  Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. , 1993, Gut.

[95]  M. Grilli,et al.  NF-kappa B and Rel: participants in a multiform transcriptional regulatory system. , 1993, International review of cytology.

[96]  Tran Dd,et al.  Evaluation of severity in patients with acute pancreatitis. , 1992 .

[97]  J. Schölmerich,et al.  lnterleukin‐8 and neutrophil activation in acute pancreatitis , 1992, European journal of clinical investigation.

[98]  H. Reber,et al.  Influence of levamisole on pancreatic infection in acute pancreatitis. , 1992, American journal of surgery.

[99]  D. Remick,et al.  Anti-tumor necrosis factor antibody augments edema formation in caerulein-induced acute pancreatitis. , 1991, The Journal of surgical research.

[100]  C. Scheibenbogen,et al.  Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. , 1991, Gastroenterology.

[101]  J. Meakins,et al.  Therapeutic Approaches to Anergy In Surgical Patients: Surgery and Levamisole , 1979, Annals of surgery.

[102]  Meakins Jl,et al.  Neutrophil function in surgical patients: in vitro correlation of abnormal neutrophil chemotaxis by Levamisole. , 1979 .

[103]  C. Imrie,et al.  Arterial hypoxia in acute pancreatitis , 1977, The British journal of surgery.