Pharmacokinetic behaviour of clinically important TCM prescriptions

Traditional Chinese Medicine (TCM), has played a vital role in human health and welfare for a long period. Traditional Chinese Medicine prescription is the prime application scheme of TCM. Combination of two or more medicinal herbs is one of the most important and fundamental characteristic of TCM prescription. In light of their simplicity and the basic qualities of complex prescription, multi herb formulations (extract, decoction and etc) are of great significance in the considerations of herb compatibility, standardization, safety evaluation, therapeutic potential and mechanism of action of multi herb formulations. Several research papers have been published that state therapeutic activity of multi herb formulations but few are discussing the exact role of herbal combinations. To provide satisfactory data about rationality and compatibility of these TCM prescription and for pharmacokinetic profile, we reviewed the pharmacokinetic profile of 30 different clinically important TCM prescriptions.

[1]  Ranjeet P. Dash,et al.  Comparative pharmacokinetic profiles of picrosides I and II from kutkin, Picrorhiza kurroa extract and its formulation in rats. , 2013, Fitoterapia.

[2]  Hong-wu Zhang,et al.  Comparative Pharmacokinetics of Naringin in Rat after Oral Administration of Chaihu-Shu-Gan-San Aqueous Extract and Naringin Alone , 2013, Metabolites.

[3]  P. Ma,et al.  Phytic acid enhances the oral absorption of isorhamnetin, quercetin, and kaempferol in total flavones of Hippophae rhamnoides L. , 2014, Fitoterapia.

[4]  Qiang Fu,et al.  Comparative study of pharmacokinetics and tissue distribution of osthole in rats after oral administration of pure osthole and Libanotis buchtormensis supercritical extract. , 2013, Journal of ethnopharmacology.

[5]  Piyush Mehta,et al.  A Comprehensive Review on Pharmacokinetic Profile of Some Traditional Chinese Medicines , 2016 .

[6]  Yueyue Li,et al.  Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu-Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats. , 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[7]  Jian Shi,et al.  Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method. , 2013, Journal of pharmaceutical and biomedical analysis.

[8]  T. Tsai,et al.  Determination the active compounds of herbal preparation by UHPLC-MS/MS and its application on the preclinical pharmacokinetics of pure ephedrine, single herbal extract of Ephedra, and a multiple herbal preparation in rats. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[9]  Guoqing Zhang,et al.  Comparative Pharmacokinetics of Hypaconitine after Oral Administration of Pure Hypaconitine, Aconitum carmichaelii Extract and Sini Decoction to Rats , 2015, Molecules.

[10]  Liling Wang,et al.  Pharmacokinetic synergy from the taxane extract of Taxus chinensis improves the bioavailability of paclitaxel. , 2015, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[11]  L. Kong,et al.  Comparative pharmacokinetics of paeoniflorin in plasma of vascular dementia and normal rats orally administrated with Danggui-Shaoyao-San or pure paeoniflorin. , 2011, Fitoterapia.

[12]  Longshan Zhao,et al.  Comparative pharmacokinetics of three triterpene acids in rat plasma after oral administration of Poria extract and its formulated herbal preparation: GuiZhi-FuLing capsule. , 2012, Fitoterapia.

[13]  K. Bi,et al.  Comparative pharmacokinetic behavior of glycyrrhetic acid after oral administration of glycyrrhizic acid and Gancao-Fuzi-Tang. , 2004, Biological & pharmaceutical bulletin.

[14]  Nan Zhang,et al.  LC-MS/MS Determination and Pharmacokinetic Study of Pedunculoside in Rat Plasma after Oral Administration of Pedunculoside and Ilex rotunda Extract , 2015, Molecules.

[15]  X. Di,et al.  Comparative pharmacokinetics of dehydroevodiamine and coptisine in rat plasma after oral administration of single herbs and Zuojinwan prescription. , 2011, Fitoterapia.

[16]  Xiaohui Chen,et al.  Determination and pharmacokinetics of isoferulic acid in rat plasma by high-performance liquid chromatography after oral administration of isoferulic acid and Rhizoma Cimicifugae extract. , 2008, Journal of pharmaceutical and biomedical analysis.

[17]  M. Hattori,et al.  In‐vivo Assessment of Extrahepatic Metabolism of Paeoniflorin in Rats: Relevance to Intestinal Floral Metabolism , 1997, The Journal of pharmacy and pharmacology.

[18]  Liang Liu,et al.  Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC-DAD-MS method. , 2008, Journal of pharmaceutical and biomedical analysis.

[19]  Jun-song Li,et al.  Comparative pharmacokinetic and bioavailability studies of three salvianolic acids after the administration of Salviae miltiorrhizae alone or with synthetical borneol in rats. , 2011, Fitoterapia.

[20]  Hang Zeng,et al.  Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats. , 2013, Fitoterapia.

[21]  Guangji Wang,et al.  Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats. , 2008, Journal of ethnopharmacology.

[22]  R. Vaclavikova,et al.  Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants , 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.

[23]  Li-wei Guo,et al.  Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats. , 2010, Fitoterapia.

[24]  Li Wu,et al.  Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography-tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[25]  Piyush Mehta,et al.  Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants—A comprehensive review , 2015, Journal of traditional and complementary medicine.

[26]  Chang-xiao Liu,et al.  Comparative pharmacokinetics of swertiamarin in rats after oral administration of swertiamarin alone, Qing Ye Dan tablets and co-administration of swertiamarin and oleanolic acid. , 2013, Journal of ethnopharmacology.

[27]  Zheng-Tao Wang,et al.  Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats--comparison with gentiopicroside alone. , 2007, Journal of pharmaceutical and biomedical analysis.

[28]  Zhenzhong Wang,et al.  Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS after oral administration of Iris tectorum Maxim extract and pure tectoridin. , 2015, Journal of pharmaceutical and biomedical analysis.

[29]  Kyung-Mi Joo,et al.  Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method. , 2010, Journal of pharmaceutical and biomedical analysis.

[30]  Zhongqiu Liu,et al.  Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS. , 2012, Journal of Ethnopharmacology.

[31]  Zheng-Tao Wang,et al.  Comparative pharmacokinetic study of paeoniflorin after oral administration of decoction of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats. , 2008, Journal of ethnopharmacology.

[32]  Xiurong Yuan,et al.  Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. , 2012, Fitoterapia.

[33]  Liang Zhao,et al.  Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats. , 2009, Journal of ethnopharmacology.

[34]  Hongbin Xiao,et al.  Comparative pharmacokinetics of gastrodin in rats after intragastric administration of free gastrodin, parishin and Gastrodia elata extract. , 2015, Journal of ethnopharmacology.

[35]  Ying Wang,et al.  Pharmacokinetic Comparisons of Benzoylmesaconine in Rats Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry after Administration of Pure Benzoylmesaconine and Wutou Decoction , 2014, Molecules.