Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.

[1]  C. Supuran,et al.  Drug Design of Zinc-Enzyme Inhibitors , 2009 .

[2]  C. Supuran,et al.  Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives. , 2009, Bioorganic & medicinal chemistry letters.

[3]  C. Supuran,et al.  Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. , 2009, Bioorganic & medicinal chemistry letters.

[4]  A. Scaloni,et al.  Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. , 2009, Journal of medicinal chemistry.

[5]  C. Supuran,et al.  Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. , 2008, Bioorganic & medicinal chemistry.

[6]  C. Supuran,et al.  Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV. , 2008, Bioorganic & medicinal chemistry.

[7]  C. Supuran,et al.  Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines. , 2008, Bioorganic & medicinal chemistry letters.

[8]  A. Harris,et al.  Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths* , 2008, Journal of Biological Chemistry.

[9]  C. Supuran,et al.  Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. , 2008, Bioorganic & medicinal chemistry letters.

[10]  A. Harris,et al.  Cancer‐associated, hypoxia‐inducible carbonic anhydrase IX facilitates CO2 diffusion , 2008, BJU international.

[11]  C. Supuran,et al.  Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines. , 2008, Bioorganic & medicinal chemistry.

[12]  C. Supuran.  Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides. , 2008, Current pharmaceutical design.

[13]  C. Supuran,et al.  Carbonic anhydrase activation and the drug design. , 2008, Current pharmaceutical design.

[14]  C. Supuran.  Carbonic anhydrases--an overview. , 2008, Current pharmaceutical design.

[15]  C. Supuran,et al.  Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. , 2008, Current pharmaceutical design.

[16]  Claudiu T. Supuran,et al.  Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.

[17]  C. Supuran,et al.  Carbonic Anhydrase Activators as Potential Anti-Alzheimer's Disease Agents , 2007 .

[18]  C. Simons,et al.  Protein Misfolding in Neurodegenerative Diseases : Mechanisms and Therapeutic Strategies , 2007 .

[19]  C. Supuran,et al.  Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines. , 2007, Bioorganic & medicinal chemistry.

[20]  K. Kaila,et al.  Carbonic anhydrase activators: activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines. , 2007, Bioorganic & medicinal chemistry letters.

[21]  Andrea Scozzafava,et al.  Carbonic anhydrases as targets for medicinal chemistry. , 2007, Bioorganic & medicinal chemistry.

[22]  C. Supuran.  Carbonic anhydrases as drug targets--an overview. , 2007, Current topics in medicinal chemistry.

[23]  C. Supuran,et al.  Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV. , 2007, Current topics in medicinal chemistry.

[24]  C. Supuran.  Therapeutic applications of the carbonic anhydrase inhibitors , 2007 .

[25]  C. Supuran,et al.  Carbonic Anhydrase: Its Inhibitors and Activators , 2007 .

[26]  C. Supuran,et al.  Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines. , 2007, Bioorganic & medicinal chemistry letters.

[27]  C. Supuran,et al.  Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. , 2007, Bioorganic & medicinal chemistry letters.

[28]  C. Supuran,et al.  Carbonic anhydrase inhibitors and activators and their use in therapy , 2006 .

[29]  C. Supuran,et al.  Carbonic anhydrase activators: the first X-ray crystallographic study of an adduct of isoform I. , 2006, Bioorganic & medicinal chemistry letters.

[30]  C. Supuran,et al.  Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. , 2006, Chemistry.

[31]  C. Supuran,et al.  Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines. , 2006, Bioorganic & medicinal chemistry letters.

[32]  W. Sly,et al.  Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. , 2005, The Biochemical journal.

[33]  C. Supuran,et al.  Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. , 2004, Journal of enzyme inhibition and medicinal chemistry.

[34]  W. Sly,et al.  Expression, Assay, and Structure of the Extracellular Domain of Murine Carbonic Anhydrase XIV , 2004, Journal of Biological Chemistry.

[35]  C. Supuran,et al.  Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1. , 2002, Bioorganic & medicinal chemistry letters.

[36]  D. Alkon,et al.  Carbonic anhydrase gating of attention: memory therapy and enhancement. , 2002, Trends in pharmacological sciences.

[37]  C. Supuran,et al.  Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold. , 2002, Journal of medicinal chemistry.

[38]  C. Supuran,et al.  Carbonic anhydrase activators: design of high affinity isozymes I, II, and IV activators, incorporating tri-/tetrasubstituted-pyridinium-azole moieties. , 2002, Journal of medicinal chemistry.

[39]  D. Alkon,et al.  Pharmacological enhancement of synaptic efficacy, spatial learning, and memory through carbonic anhydrase activation in rats. , 2001, The Journal of pharmacology and experimental therapeutics.

[40]  C. Supuran,et al.  Carbonic Anhydrase Activators: Synthesis of High Affinity Isozymes I, II and IV Activators, Derivatives of 4-(4-Tosylureido-Amino Acyl)Ethyl-1H-Imidazole (Histamine Derivatives) , 2000, Journal of enzyme inhibition.

[41]  P. Härkönen,et al.  Carbonic anhydrase III protects cells from hydrogen peroxide‐induced apoptosis , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[42]  S Mangani,et al.  Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine. , 1997, Biochemistry.

[43]  W. Sly,et al.  Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[44]  Carol A. Fierke,et al.  Carbonic Anhydrase: Evolution of the Zinc Binding Site by Nature and by Design , 1996 .

[45]  C. Supuran,et al.  Carbonic anhydrase activators. 3: structure-activity correlations for a series of isozyme II activators. , 1994, Journal of pharmaceutical sciences.

[46]  S. Nair,et al.  Unexpected Ph-Dependent Conformation of His-64, the Proton Shuttle of Carbonic Anhydrase II. , 1992 .

[47]  Y. Edwards,et al.  The carbonic anhydrases : new horizons , 2000 .

[48]  C. Supuran,et al.  Activation of carbonic anhydrase isozymes. , 2000, EXS.

[49]  W. Sly,et al.  Human carbonic anhydrases and carbonic anhydrase deficiencies. , 1995, Annual review of biochemistry.

[50]  C. Supuran,et al.  Carbonic anhydrases , 2019, Carbonic Anhydrases.