Toxoplasmosis in a group of glucose-6-phosphate dehydrogenase deficient patients.
暂无分享,去创建一个
OBJECTIVE
This was a retrospective study that aimed at evaluating the relative risk of Toxoplasma infection in patients with glucose-6-phosphate dehydrogenase deficiency as compared to a control group with no glucose-6-phosphate dehydrogenase deficiency.
METHODS
Ninety-one blood donor volunteers had serology testing from Toxoplasma gondii and were screened for glucose-6-phosphate dehydrogenase deficiency by a qualitative method using fluorescent spot test. They were all males and their ages ranged from 17 to 52 years.
RESULTS
Fifty-three persons (58%) were glucose-6-phosphate dehydrogenase deficient and 38 (42%) were glucose-6-phosphate dehydrogenase normal. In the glucose-6-phosphate dehydrogenase deficient group, 31 (58.5%) had positive titers for Toxoplasma; while in the glucose-6-phosphate dehydrogenase normal group 9 persons (24%) had positive titers for Toxoplasma. The relative risk of infection was 2.5 times more in the glucose-6-phosphate dehydrogenase deficient group, a statistically significant difference with a p value of 0.002.
CONCLUSION
Glucose-6-phosphate dehydrogenase deficiency seems to increase the risk for Toxoplasma infection by 2.5 fold probably due to decreased killing effect, of phagocytic cells.
[1] R. Hann,et al. Incidence and causes of sepsis in glucose-6-phosphate dehydrogenase-deficient newborn infants. , 1989, The Journal of pediatrics.
[2] N. Saha,et al. Distribution of red cell G6PD and 6PGD phenotypes in Saudi Arabia. , 1986, Tropical and geographical medicine.