BioNMR in drug research

Preface.Foreword.List of Authors.List of Abbreviations.PART I: BASIC TECHNIQUES.Modern Methods for the Expression of Proteins in Isotopically Enriched Form (H. Patzelt, et al.).Structure Calculation Using Automated Techniques (P. Guntert).Achieving Better Sensitivity, Less Noise and Fewer Artifacts in NMR Spectra (D. Moskau & O. Zerbe).PART II: NMR OF BIOMOLECULES.NMR Strategies for Protein Assignments (V. Dotsch).NMR of Membrane-Associated Peptides and Proteins (R. Bader, et al.).NMR of Nucleic Acids (R. Fiala & V. Sklenar). PART III MODERN SPECTROSCOPIC TECHNIQUES.Methods for the Measurement of Angle Restraints from Scalar, Dipolar Couplings from Cross-Correlated Relaxation: Application to Biomacromolecules (C. Griesinger).Orientational Restraints (E. de Alba & N. Tjandra).Scalar Coupling Across Hydrogen Bonds (A. Dingley, et al.).TROSY: Transverse Relaxation-Optimized Spectroscopy (R. Riek).MAS Solid-State NMR of Isotopically Enriched Biological Samples (P. Williamson , et al.).Determination of Protein Dynamics Using 15N Relaxation Measurements (D. Fushman). PART IV: TOOLS FOR INVESTIGATION OF DRUG - RECEPTOR COMPLEXES AND FOR LIGAND SCREENING.The Determination of Equilibrium Dissociation Constants of Protein-Ligand Complexes by NMR (G. Roberts).Experiments in NMR-Based Screening (C. Marchioro, et al.).The Use of Spin Labels in NMR-Supported Lead Finding and Optimization (W. Jahnke).NMR of Weakly Binding Ligands (M. Blommers & S. Rudisser).Isotope Filter and Editing Techniques (G. Gemmecker). PART V: STRATEGIES FOR DRUG DEVELOPMENT USING NMR.Strategies for NMR Screening and Library Design (C. Lepre).Strategies for Hit Finding Using NMR (W. Klaus & H. Senn).Strategies for Drug Discovery Using NMR (M. Blommers, et al.).NMR-Based Drug Design: Approaches for Very Large Proteins (M. Pellecchia, et al.).Subject Index.