A porcine model of acute quadriplegic myopathy: a feasibility study

Background:  The mechanisms underlying acute quadriplegic myopathy (AQM) are poorly understood, partly as a result of the fact that patients are generally diagnosed at a late stage of the disease. Accordingly, there is a need for relevant experimental animal models aimed at identifying underlying mechanisms.

[1]  O. Rooyackers,et al.  Effect of prolonged mechanical ventilation on diaphragm muscle mitochondria in piglets , 2005, Acta anaesthesiologica Scandinavica.

[2]  T. Ziegler,et al.  Myopathies in critical illness: characterization and nutritional aspects. , 2005, The Journal of nutrition.

[3]  G. Liistro,et al.  Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm , 2003, Intensive Care Medicine.

[4]  H. Sander,et al.  Quadriplegic areflexic ICU illness: Selective thick filament loss and normal nerve histology , 2002, Muscle & nerve.

[5]  D. Nichols,et al.  Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm function , 2002, Intensive Care Medicine.

[6]  B. Allaouchiche,et al.  Influence of sepsis on minimum alveolar concentration of desflurane in a porcine model. , 2001, British journal of anaesthesia.

[7]  T. Mozaffar Critical illness myopathy , 2001, Muscle & nerve.

[8]  P. Seibel,et al.  Differential expression of myosin heavy-chain mRNA in muscles of mastication during functional advancement of the mandible in pigs. , 2001, Archives of oral biology.

[9]  A. D'Amico,et al.  Apoptotic features accompany acute quadriplegic myopathy , 2000, Neurology.

[10]  N. Matsumoto,et al.  Analysis of muscle proteins in acute quadriplegic myopathy , 2000, Muscle & nerve.

[11]  Douglas Thompson,et al.  The impact of long‐term acute‐care facilities on the outcome and cost of care for patients undergoing prolonged mechanical ventilation , 2000, Critical care medicine.

[12]  L. Larsson,et al.  Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: Mechanisms at the cellular and molecular levels , 2000, Critical care medicine.

[13]  M. Rich,et al.  Altered Gene Expression in Steroid-Treated Denervated Muscle , 1999, Neurobiology of Disease.

[14]  Ò. Miró,et al.  Acute quadriplegic myopathy with myosin-deficient muscle fibres after liver transplantation: defining the clinical picture and delimiting the risk factors. , 1999, Transplantation.

[15]  M. Giuliani,et al.  Causes of neuromuscular weakness in the intensive care unit: A study of ninety‐two patients , 1998, Muscle & nerve.

[16]  M. Pinter,et al.  Loss of electrical excitability in an animal model of acute quadriplegic myopathy , 1998, Annals of neurology.

[17]  W. Frontera,et al.  Contractile studies of single human skeletal muscle fibers: A comparison of different muscles, permeabilization procedures, and storage techniques , 1997, Muscle & nerve.

[18]  A. Engel,et al.  Acute quadriplegic myopathy: Analysis of myosin isoforms and evidence for calpain‐mediated proteolysis , 1997, Muscle & nerve.

[19]  A. V. Cott,et al.  Acute myopathy of intensive care: Clinical, electromyographic, and pathological aspects , 1996, Annals of neurology.

[20]  W S David,et al.  Muscle weakness in mechanically ventilated patients with severe asthma. , 1996, American journal of respiratory and critical care medicine.

[21]  M. Rich,et al.  Muscle is electrically inexcitable in acute quadriplegic myopathy , 1996, Neurology.

[22]  M. Copin,et al.  Experimental models of tracheobronchial stenoses: a useful tool for evaluating airway stents. , 1995, The Annals of thoracic surgery.

[23]  A. Greenburg,et al.  Effects of inhaled nitric oxide on right ventricular function in endotoxin shock. , 1995, The Journal of trauma.

[24]  J. Dasta,et al.  Prolonged paralysis in intensive care unit patients after the use of neuromuscular blocking agents: A review of the literature , 1994, Critical care medicine.

[25]  D. Ramsay,et al.  Acute necrotizing myopathy of intensive care: Electrophysiological studies , 1994, Muscle & nerve.

[26]  L. Larsson,et al.  Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles. , 1993, The Journal of physiology.

[27]  A. Karlsson,et al.  Muscle histochemical and biochemical properties in relation to meat quality during selection for increased lean tissue growth rate in pigs. , 1993, Journal of animal science.

[28]  D. Lacomis,et al.  Acute myopathy and neuropathy in status asthmaticus: Case report and literature review , 1993, Muscle & nerve.

[29]  M. Weinmann,et al.  Myopathy in severe asthma. , 1992, The American review of respiratory disease.

[30]  R. Schellens,et al.  Critical illness polyneuromyopathy after artificial respiration , 1991, Clinical Neurology and Neurosurgery.

[31]  Z. Hodny,et al.  Staining and quantification of proteins separated by polyacrylamide gel electrophoresis. , 1991, Journal of chromatography.

[32]  Marinos C. Dalakas,et al.  Muscle biopsy — a practical approach , 1986, The Ulster Medical Journal.

[33]  I. MacFarlane,et al.  SEVERE MYOPATHY AFTER STATUS ASTHMATICUS , 1977, The Lancet.

[34]  M. Brooke,et al.  SOME COMMENTS ON THE HISTOCHEMICAL CHARACTERIZATION OF MUSCLE ADENOSINE TRIPHOSPHATASE , 1969, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[35]  G. Liistro,et al.  An improved porcine model of stable methacholine-induced bronchospasm , 2002, Intensive Care Medicine.

[36]  M. Copin,et al.  Characterization of an animal model of ventilator-acquired pneumonia. , 1999, Chest.

[37]  L. Schook,et al.  Advances in Swine in Biomedical Research , 1996, Springer US.