Regression based quasi-experimental approach when randomisation is not an option: interrupted time series analysis

Interrupted time series analysis is a quasi-experimental design that can evaluate an intervention effect, using longitudinal data. The advantages, disadvantages, and underlying assumptions of various modelling approaches are discussed using published examples

[1]  Evangelos Kontopantelis,et al.  Withdrawing performance indicators: retrospective analysis of general practice performance under UK Quality and Outcomes Framework , 2014, BMJ : British Medical Journal.

[2]  Sophia Rabe-Hesketh,et al.  Multilevel and Longitudinal Modeling Using Stata , 2005 .

[3]  Evangelos Kontopantelis,et al.  A Re-Analysis of the Cochrane Library Data: The Dangers of Unobserved Heterogeneity in Meta-Analyses , 2013, PloS one.

[4]  A K Wagner,et al.  Segmented regression analysis of interrupted time series studies in medication use research , 2002, Journal of clinical pharmacy and therapeutics.

[5]  S. Wild,et al.  External validity of randomized controlled trials of glycaemic control and vascular disease: how representative are participants? , 2013, Diabetic medicine : a journal of the British Diabetic Association.

[6]  Sophia Rabe-Hesketh,et al.  Multilevel and Longitudinal Modeling Using Stata (3rd Edition), Vol II , 2012 .

[7]  Paul Wilkinson,et al.  Effect of 20 mph traffic speed zones on road injuries in London, 1986-2006: controlled interrupted time series analysis , 2009, BMJ : British Medical Journal.

[8]  B. Efron.  The Bootstrap and Modern Statistics , 2000 .

[9]  S. Silverman,et al.  From randomized controlled trials to observational studies. , 2009, The American journal of medicine.

[10]  Evangelos Kontopantelis,et al.  Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework , 2011, BMJ : British Medical Journal.

[11]  Gianluca Baio,et al.  Regression discontinuity designs: an approach to the evaluation of treatment efficacy in primary care using observational data , 2014, BMJ : British Medical Journal.

[12]  J. Daurès,et al.  Impact of infection control interventions and antibiotic use on hospital MRSA: a multivariate interrupted time-series analysis. , 2007, International journal of antimicrobial agents.

[13]  P. Arbogast,et al.  Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis , 2007, The Lancet.

[14]  B. Sibbald,et al.  Effects of pay for performance on the quality of primary care in England. , 2009, The New England journal of medicine.

[15]  Evangelos Kontopantelis,et al.  Recorded quality of primary care for patients with diabetes in England before and after the introduction of a financial incentive scheme: a longitudinal observational study , 2012, BMJ quality & safety.

[16]  B. Guthrie,et al.  Adapting clinical guidelines to take account of multimorbidity , 2012, BMJ : British Medical Journal.