In this article, the equivalent relationship between the nearest-three-virtual space vector and carrier-based pulsewidth-modulation scheme is established based on space vector coordinate for a three-level neutral-point-clamped (3L-NPC) converter. Moreover, to solve the neutral-point voltage imbalance problem of the studied 3L-NPC converter-fed high-speed drives, an active modulation strategy with the generalized bias-offset injection technique is proposed. Meanwhile, the excessive computational burden is significantly overcome by the fast calculation approach. The effectiveness of the proposed modulation algorithm is validated through both simulation and experimental results obtained from a 45 kW, 32 kr/min aircraft electric starter/generator prototype system.