The effects of the mode of delivery on oxidative-antioxidative balance

Objective. The purpose of this study was to investigate the effects of the mode of delivery on the oxidant and antioxidant systems in mothers and infants and to demonstrate which mode leads more oxidative stress. Methods. The participants were divided into two groups according to the mode of their labour and delivery: group 1 (n = 33) women with normal labour and delivery and group 2 (n = 33) with scheduled caesarean section (C/S) and delivery. The maternal, cord, and infant blood samples in both groups were collected. The serum total antioxidant capacity (TAC) and the total oxidant status (TOS) were evaluated by using an automated colorimetric measurement method. Results. The parameters indicating oxidative stress (TOS, oxidative stress index, and lipid hydroperoxide) in maternal, cord, and newborn blood samples were higher in patients delivering with C/S than those normal spontaneous vaginal deliveries (NSVD) patient group, while it was vice versa for TAC. Conclusions. It may be concluded that both the mothers and neonates in C/S group are exposed to higher oxidative stress as compared with those in NSVD group and the antioxidant mechanisms are insufficient to cope with this stress during C/S. This result indicates that the normal delivery through the physiological route is healthier for the bodies of mothers and infants.

[1]  P. Fowler,et al.  The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. , 2010, The international journal of biochemistry & cell biology.

[2]  P. Ward,et al.  Oxidative stress: acute and progressive lung injury , 2010, Annals of the New York Academy of Sciences.

[3]  H. Al kadri,et al.  Role of oxidative stress in the pathogenesis of preeclampsia , 2010, Archives of Gynecology and Obstetrics.

[4]  C. Banupriya,et al.  Oxidative stress in perinatal asphyxia in relation to outcome , 2010, Indian journal of pediatrics.

[5]  R. Ford,et al.  Cholinergic and oxidative stress mechanisms in sudden infant death syndrome , 2009, Acta paediatrica.

[6]  R. Auten,et al.  Oxygen Toxicity and Reactive Oxygen Species: The Devil Is in the Details , 2009, Pediatric Research.

[7]  I. Papassotiriou,et al.  Maternal-neonatal serum paraoxonase 1 activity in relation to the mode of delivery. , 2006, Clinical biochemistry.

[8]  O. Erel,et al.  A new automated colorimetric method for measuring total oxidant status. , 2005, Clinical biochemistry.

[9]  O. Erel,et al.  Increased oxidative stress in children exposed to passive smoking. , 2005, International journal of cardiology.

[10]  T. Kaneko,et al.  The effects of moderate, strenuous, and overtraining on oxidative stress markers and DNA repair in rat liver. , 2005, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[11]  I. Young,et al.  Regulation of free radical outflow from an isolated muscle bed in exercising humans. , 2004, American journal of physiology. Heart and circulatory physiology.

[12]  O. Erel.  A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. , 2003, Clinical biochemistry.

[13]  O. Saugstad.  Bronchopulmonary dysplasia-oxidative stress and antioxidants. , 2003, Seminars in neonatology : SN.

[14]  C. Groussard,et al.  Changes in blood lipid peroxidation markers and antioxidants after a single sprint anaerobic exercise , 2003, European Journal of Applied Physiology.

[15]  L. Kovács,et al.  Antioxidant enzyme activities are decreased in preterm infants and in neonates born via caesarean section. , 2002, European journal of obstetrics, gynecology, and reproductive biology.

[16]  R. Reiter,et al.  Causes of Oxidative Stress in the Pre- and Perinatal Period , 2002, Neonatology.

[17]  M. Akisu,et al.  The Role of Recombinant Human Erythropoietin in Lipid Peroxidation and Platelet-Activating Factor Generation in a Rat Model of Necrotizing Enterocolitis , 2001, European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.

[18]  G. Ohel,et al.  Reactive oxygen species in the process of labor , 1999, Archives of Gynecology and Obstetrics.

[19]  J. Nourooz-Zadeh.  Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma. , 1999, Methods in enzymology.

[20]  C. Anuradha,et al.  Exercise, depletion of antioxidants and antioxidant manipulation , 1998, Cell biochemistry and function.

[21]  C. Redman,et al.  Circulating markers of oxidative stress are raised in normal pregnancy and pre‐eclampsia , 1998, British journal of obstetrics and gynaecology.

[22]  J. Roberts,et al.  Low-Density Lipoprotein Particle Size Decreases During Normal Pregnancy in Association With Triglyceride Increases , 1998, The Journal of the Society for Gynecologic Investigation: JSGI.

[23]  J. Mongelli,et al.  Lipid peroxidation in cord blood at birth: the effect of labour , 1998, British journal of obstetrics and gynaecology.

[24]  P. Chessex,et al.  Development of glutathione synthesis and gamma-glutamyltranspeptidase activities in tissues from newborn infants. , 1998, Free radical biology & medicine.

[25]  Ş. Yiğit,et al.  Serum malondialdehyde concentration as a measure of oxygen free radical damage in preterm infants. , 1998, The Turkish journal of pediatrics.

[26]  J. Keul,et al.  Lipid peroxidation and antioxidative vitamins under extreme endurance stress. , 1994, Acta physiologica Scandinavica.

[27]  R. Tuimala,et al.  Pregnancy-induced hypertension is associated with changes in maternal and umbilical blood antioxidants. , 1993, Gynecologic and obstetric investigation.