Thiocoraline , a NewDepsipeptide with Antitumor Activity Produced by a Marine Micromonospora I . Taxonomy , Fermentation , Isolation , and Biological Activities

A novel bioactive depsipeptide, thiocoraline, was isolated from the mycelial cake of a marine actinomycete strain L-1 3-ACM2-092.Based on morphological, cultural, physiological, and chemical characteristics, strain L-13-ACM2-092was ascribed to the genus Micromonospora. Thiocoraline showed a potent cytotoxic activity against P-388, A-549 and MEL-28cell lines, and also a strong antimicrobial activity against Gram-positive microorganisms. This compoundbinds to supercoiled DNAand inhibits RNAsynthesis.

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