Image processing of human corneal endothelium based on a learning network.

We applied a learning network to a cell's boundary detection of human corneal endothelium photomicrographs measured by specular microscopy. Interconnections between units in our model are constrained to be locally space invariant to meet space-invariant processing. The neural network was trained to extract the cell's boundary by showing part of the photomicrograph and its subjective boundary image, which is an outline drawing made by hand. After training, the network showed good performance with the microphotograph that was not trained. Internal representations of the network were also studied.

[1]  R A Laing,et al.  Specular microscopy of the cornea. , 1980, Current topics in eye research.

[2]  J. F. Brenner,et al.  Two graph searching techniques for boundary finding in white blood cell images. , 1978, Computers in biology and medicine.

[3]  J. F. Brenner,et al.  Automated morphometric analysis of corneal endothelial cells. , 1981, Investigative ophthalmology & visual science.

[4]  C J Koester,et al.  Scanning mirror microscope with optical sectioning characteristics: applications in ophthalmology. , 1980, Applied optics.

[5]  Laing Ra,et al.  Specular microscopy of the cornea. , 1980 .

[6]  Takayuki Ito,et al.  Neocognitron: A neural network model for a mechanism of visual pattern recognition , 1983, IEEE Transactions on Systems, Man, and Cybernetics.

[7]  Y Ichioka,et al.  Parallel distributed processing model with local space-invariant interconnections and its optical architecture. , 1990, Applied optics.

[8]  Kendall Preston,et al.  Tissue section analysis: Feature selection and image processing , 1981, Pattern Recognit..

[9]  Terrence J. Sejnowski,et al.  Learned classification of sonar targets using a massively parallel network , 1988, IEEE Trans. Acoust. Speech Signal Process..

[10]  Geoffrey E. Hinton,et al.  Learning internal representations by error propagation , 1986 .

[11]  Chuanyi Ji,et al.  Generalizing Smoothness Constraints from Discrete Samples , 1990, Neural Computation.

[12]  Geoffrey E. Hinton,et al.  A Learning Algorithm for Boltzmann Machines , 1985, Cogn. Sci..

[13]  E G Stocker,et al.  Corneal endothelial polymegathism induced by PMMA contact lens wear. , 1985, Investigative ophthalmology & visual science.