ABSTRACT Aim: Burnout could potentially have serious negative impact on quality of cancer care, professional satisfaction and personal life. Our aim was to investigate the burnout prevalence, work and lifestyle factors amongst European oncologists ≤40 (YOs). Methods: A survey was conducted using the validated Maslach Burnout Inventory (MBI) and additional questions exploring work/ lifestyle factors. Parametric and non-parametric analyses were performed to identify factors associated with burnout and multivariate analyses to derive a predictive burnout model. Results: 737 surveys (all ages) were collected from 41 European countries. Countries were divided into 6 regions. Results from 595 (81%) YOs were included (81% medical oncologists; 52% trainees, 62% women). 71% of YOs showed burnout (burnout indices: depersonalisation 50%; emotional exhaustion 35%; low accomplishment 35%). 22% requested support for burnout during training and 74% reported no hospital access to support services. Burnout rates were significantly different across Europe (p Conclusions: This is the largest burnout survey of European YOs. Burnout is common amongst YOs and rates vary across Europe. Achieving a good work/life balance and adequate vacation time may reduce burnout levels. Raising burnout awareness, support for oncologists and interventional research are needed. Disclosure: All authors have declared no conflicts of interest.