Generation of protein isoform diversity by alternative initiation of translation at non‐AUG codons

[1]  H. Prats,et al.  Translokin is an intracellular mediator of FGF-2 trafficking , 2003, Nature Cell Biology.

[2]  P. Claus,et al.  Differential Intranuclear Localization of Fibroblast Growth Factor-2 Isoforms and Specific Interaction with the Survival of Motoneuron Protein* , 2003, The Journal of Biological Chemistry.

[3]  L. Ryabova,et al.  Viral strategies of translation initiation: Ribosomal shunt and reinitiation , 2002, Progress in Nucleic Acid Research and Molecular Biology.

[4]  T. Pestova,et al.  The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection. , 2002, Genes & development.

[5]  L. Magnelli,et al.  Overexpression of the 18 kDa and 22/24 kDa FGF‐2 isoforms results in differential drug resistance and amplification potential , 2002, Journal of cellular physiology.

[6]  C. Pfarr,et al.  Translational Regulation of the JunD Messenger RNA* , 2002, The Journal of Biological Chemistry.

[7]  Vadim N. Gladyshev,et al.  How Selenium Has Altered Our Understanding of the Genetic Code , 2002, Molecular and Cellular Biology.

[8]  V. Notario,et al.  AUA as a translation initiation site in vitro for the human transcription factor Sp3. , 2002, Journal of biochemistry and molecular biology.

[9]  L. Créancier,et al.  New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation. , 2001, Molecular endocrinology.

[10]  A. Pandey,et al.  A reassessment of the translation initiation codon in vertebrates. , 2001, Trends in genetics : TIG.

[11]  R. Jaffe,et al.  A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon. , 2001, The Biochemical journal.

[12]  L. Créancier,et al.  p53 directs conformational change and translation initiation blockade of human fibroblast growth factor 2 mRNA , 2001, Oncogene.

[13]  W. Huttner,et al.  Two overlapping reading frames in a single exon encode interacting proteins—a novel way of gene usage , 2001, The EMBO journal.

[14]  A. Prats,et al.  Translation of the human c-myc P0 tricistronic mRNA involves two independent internal ribosome entry sites , 2001, Oncogene.

[15]  G. Packham,et al.  The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock , 2001, Oncogene.

[16]  P. Sarnow,et al.  Internal ribosome entry sites in eukaryotic mRNA molecules. , 2001, Genes & development.

[17]  V. Agol,et al.  Molecular mechanisms of translation initiation in eukaryotes , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[18]  M. Meiron,et al.  New isoforms of VEGF are translated from alternative initiation CUG codons located in its 5'UTR. , 2001, Biochemical and biophysical research communications.

[19]  L. Créancier,et al.  Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanism , 2001, Oncogene.

[20]  P. Claus,et al.  Distinctive Effects of Rat Fibroblast Growth Factor-2 Isoforms on PC12 and Schwann Cells , 2001, Growth factors.

[21]  N. Itoh,et al.  Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. , 2000, Biochemical and biophysical research communications.

[22]  P. Sarnow,et al.  Initiation of Protein Synthesis from the A Site of the Ribosome , 2000, Cell.

[23]  L. Créancier,et al.  Fibroblast Growth Factor 2 Internal Ribosome Entry Site (Ires) Activity Ex Vivo and in Transgenic Mice Reveals a Stringent Tissue-Specific Regulation , 2000, The Journal of cell biology.

[24]  A. Prats,et al.  Alternative Translation Initiation of Human Fibroblast Growth Factor 2 mRNA Controlled by Its 3′-Untranslated Region Involves a Poly(A) Switch and a Translational Enhancer* , 2000, The Journal of Biological Chemistry.

[25]  G. Ahmadian,et al.  Expression of the ORF‐2 protein of the human respiratory syncytial virus M2 gene is initiated by a ribosomal termination‐dependent reinitiation mechanism , 2000, The EMBO journal.

[26]  F. Morlé,et al.  Negative and Translation Termination-Dependent Positive Control of FLI-1 Protein Synthesis by Conserved Overlapping 5′ Upstream Open Reading Frames in Fli-1 mRNA , 2000, Molecular and Cellular Biology.

[27]  S. Cornelis,et al.  Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. , 2000, Molecular cell.

[28]  J. Fuxe,et al.  Translation of p15.5INK4B, an N-terminally extended and fully active form of p15INK4B, is initiated from an upstream GUG codon , 2000, Oncogene.

[29]  N. Nakashima,et al.  Methionine-independent initiation of translation in the capsid protein of an insect RNA virus. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Jouanneau,et al.  Nuclear 24 kD fibroblast growth factor (FGF)-2 confers metastatic properties on rat bladder carcinoma cells , 1999, Oncogene.

[31]  M. Kozak Initiation of translation in prokaryotes and eukaryotes. , 1999, Gene.

[32]  N. Shastri,et al.  Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. , 1999, Immunity.

[33]  D. Rifkin,et al.  Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals. , 1999, Molecular biology of the cell.

[34]  N. Itoh,et al.  Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. , 1999, Biochimica et biophysica acta.

[35]  A. Prats,et al.  A New 34-Kilodalton Isoform of Human Fibroblast Growth Factor 2 Is Cap Dependently Synthesized by Using a Non-AUG Start Codon and Behaves as a Survival Factor , 1999, Molecular and Cellular Biology.

[36]  L. Créancier,et al.  Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA , 1998, Molecular and Cellular Biology.

[37]  D. Kolakofsky,et al.  Sendai Virus Y Proteins Are Initiated by a Ribosomal Shunt , 1998, Molecular and Cellular Biology.

[38]  H. Drabkin,et al.  Initiation of Protein Synthesis in Mammalian Cells with Codons Other Than AUG and Amino Acids Other Than Methionine , 1998, Molecular and Cellular Biology.

[39]  C. Hellen,et al.  Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons , 1998, Nature.

[40]  S. Tsang,et al.  Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Florkiewicz,et al.  The Inhibition of Fibroblast Growth Factor-2 Export by Cardenolides Implies a Novel Function for the Catalytic Subunit of Na+,K+-ATPase* , 1998, The Journal of Biological Chemistry.

[42]  A. Prats,et al.  Alternative Translation of the Proto-oncogene c-mycby an Internal Ribosome Entry Site* , 1997, The Journal of Biological Chemistry.

[43]  J L Cleveland,et al.  Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. , 1997, The Biochemical journal.

[44]  M. Kozak,et al.  Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6 , 1997, The EMBO journal.

[45]  H. Prats,et al.  Radioresistance induced by the high molecular forms of the basic fibroblast growth factor is associated with an increased G2 delay and a hyperphosphorylation of p34CDC2 in HeLa cells. , 1997, Cancer research.

[46]  J. Hata,et al.  A cDNA Encoding Fish Fibroblast Growth Factor-2, Which Lacks Alternative Translation Initiation* , 1997, The Journal of Biological Chemistry.

[47]  D. Rifkin,et al.  Biological roles of fibroblast growth factor-2. , 1997, Endocrine reviews.

[48]  A. Prats,et al.  Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells , 1996, The Journal of cell biology.

[49]  D. Rifkin,et al.  Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution. , 1996, Molecular biology of the cell.

[50]  J. Pelletier,et al.  A Non-AUG Translational Initiation Event Generates Novel WT1 Isoforms (*) , 1996, The Journal of Biological Chemistry.

[51]  Kenneth J. Hillan,et al.  Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.

[52]  Lieve Moons,et al.  Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.

[53]  C. Kevil,et al.  Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation. , 1995, Oncogene.

[54]  G. Dorn,et al.  Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. , 1995, Molecular biology of the cell.

[55]  A. Prats,et al.  Alternative Translation Initiation of the Moloney Murine Leukemia Virus mRNA Controlled by Internal Ribosome Entry Involving the p57/PTB Splicing Factor (*) , 1995, The Journal of Biological Chemistry.

[56]  M. Kozak Adherence to the first-AUG rule when a second AUG codon follows closely upon the first. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[57]  A. Prats,et al.  Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes , 1995, Molecular and cellular biology.

[58]  R. Sears,et al.  The alternatively initiated c-Myc proteins differentially regulate transcription through a noncanonical DNA-binding site. , 1994, Genes & development.

[59]  D. Kolakofsky,et al.  Positions +5 and +6 can be major determinants of the efficiency of non‐AUG initiation codons for protein synthesis. , 1994, The EMBO journal.

[60]  R. Jackson,et al.  The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons. , 1994, The EMBO journal.

[61]  K. Gupta,et al.  Translation initiation from non-AUG codons in COS1 cells is mRNA species dependent. , 1994, Biochemical and biophysical research communications.

[62]  R. Zeller,et al.  Cell-type-specific nuclear translocation of fibroblast growth factor-2 isoforms during chicken kidney and limb morphogenesis. , 1994, Developmental biology.

[63]  A. Prats,et al.  cis-acting elements involved in the alternative translation initiation process of human basic fibroblast growth factor mRNA , 1992, Molecular and cellular biology.

[64]  G. D. Spotts,et al.  Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation. , 1992, Genes & development.

[65]  G. Belsham,et al.  Dual initiation sites of protein synthesis on foot‐and‐mouth disease virus RNA are selected following internal entry and scanning of ribosomes in vivo. , 1992, The EMBO journal.

[66]  T. Donahue,et al.  The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon , 1992, Molecular and cellular biology.

[67]  D. Hanahan,et al.  Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma , 1991, Cell.

[68]  D. Rifkin,et al.  Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells. , 1991, Cell regulation.

[69]  H. Prats,et al.  Potential oncogenic effects of basic fibroblast growth factor requires cooperation between CUG and AUG-initiated forms. , 1991, Cell regulation.

[70]  A R Dunn,et al.  Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization , 1991, Molecular and cellular biology.

[71]  M. Klagsbrun,et al.  Three forms of rat basic fibroblast growth factor are made from a single mRNA and localize to the nucleus , 1991, Journal of cellular physiology.

[72]  D. Rifkin,et al.  The NH2‐terminal extension of high molecular weight bFGF is a nuclear targeting signal , 1991, Journal of cellular physiology.

[73]  J. Minna,et al.  A complex pattern of translational initiation and phosphorylation in L-myc proteins. , 1991, Oncogene.

[74]  A. Berns,et al.  The pim‐1 oncogene encodes two related protein‐serine/threonine kinases by alternative initiation at AUG and CUG. , 1991, The EMBO journal.

[75]  D. Rifkin,et al.  Direct evidence for methylation of arginine residues in high molecular weight forms of basic fibroblast growth factor. , 1991, Cell regulation.

[76]  H. Prats,et al.  Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor , 1991, Molecular and cellular biology.

[77]  R. Jackson,et al.  The novel mechanism of initiation of picornavirus RNA translation. , 1990, Trends in biochemical sciences.

[78]  M. Kozak,et al.  Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[79]  A. Bernards,et al.  The ltk receptor tyrosine kinase is expressed in pre‐B lymphocytes and cerebral neurons and uses a non‐AUG translational initiator. , 1990, The EMBO journal.

[80]  D. Rifkin,et al.  Nuclear and cytoplasmic localization of different basic fibroblast growth factor species , 1990, Journal of cellular physiology.

[81]  H. Stunnenberg,et al.  The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator , 1990, Molecular and cellular biology.

[82]  V. Baldin,et al.  Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells. , 1990, The EMBO journal.

[83]  G. Peters,et al.  Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon , 1990, Nature.

[84]  M. Kozak Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems , 1989, Molecular and cellular biology.

[85]  R. Jackson,et al.  Efficient initiation of mammalian mRNA translation at a CUG codon. , 1989, Nucleic acids research.

[86]  M. Cleary,et al.  lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif , 1989, Cell.

[87]  A. Sommer,et al.  Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[88]  K. Alitalo,et al.  Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene , 1989, Molecular and cellular biology.

[89]  D. Peabody,et al.  Translation initiation at non-AUG triplets in mammalian cells. , 1989, The Journal of biological chemistry.

[90]  J. Lélias,et al.  High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[91]  J. Darlix,et al.  CUG initiation codon used for the synthesis of a cell surface antigen coded by the murine leukemia virus. , 1989, Journal of molecular biology.

[92]  E. Wimmer,et al.  A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation , 1988, Journal of virology.

[93]  N. Sonenberg,et al.  Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA , 1988, Nature.

[94]  R. Eisenman,et al.  A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas , 1988, Cell.

[95]  D. Kolakofsky,et al.  Ribosomal initiation from an ACG codon in the Sendai virus P/C mRNA. , 1988, The EMBO journal.

[96]  M. Kozak An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs. , 1987, Nucleic acids research.

[97]  J. Teissié,et al.  Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[98]  D. Peabody Translation initiation at an ACG triplet in mammalian cells. , 1987, The Journal of biological chemistry.

[99]  M. Kozak,et al.  How do eucaryotic ribosomes select initiation regions in messenger RNA? , 1978, Cell.

[100]  Sophie Bonnal,et al.  IRESdb: the Internal Ribosome Entry Site database , 2003, Nucleic Acids Res..

[101]  N. Ferrara,et al.  Vascular endothelial growth factor and the regulation of angiogenesis. , 2000, Recent progress in hormone research.

[102]  A. Prats,et al.  Cell transformation results in the loss of the density-dependent translational regulation of the expression of fibroblast growth factor 2 isoforms. , 1999, Cancer research.

[103]  A. Prats,et al.  Expression of human fibroblast growth factor-2 and cell transformation : some paradoxical aspects , 1995 .

[104]  L. Hjelmeland,et al.  Cell density regulates differential production of bFGF transcripts. , 1993, Growth factors.

[105]  R. Jackson,et al.  Selection of the 5'-proximal translation initiation site is influenced by mRNA and eIF-2 concentrations. , 1990, European journal of biochemistry.