Dynamic Interpretation of Hedgehog Signaling in the Drosophila Wing Disc

Drosophila cell response to the Hedgehog morphogen depends not just on a precise measurement of morphogen concentration at any given time, but instead on the history of cell exposure to morphogen.

[1]  E. Sánchez-Herrero,et al.  The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development. , 1994, The EMBO journal.

[2]  E. Hafen,et al.  Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells , 1999, Cell.

[3]  Naama Barkai,et al.  Self-enhanced ligand degradation underlies robustness of morphogen gradients. , 2003, Developmental cell.

[4]  R. L. Johnson,et al.  patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. , 1995, Development.

[5]  P. Ingham,et al.  Mutations in the Sterol Sensing Domain of Patched suggest a Role for Vesicular Trafficking in Smoothened Regulation , 2001, Current Biology.

[6]  Denis Thieffry,et al.  Logical modelling of the role of the Hh pathway in the patterning of the Drosophila wing disc , 2008, ECCB.

[7]  M. Freeman,et al.  Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. , 1996, Development.

[8]  M. Brodsky,et al.  Quantitative analysis of Hedgehog gradient formation using an inducible expression system , 2007, BMC Developmental Biology.

[9]  Nikolay A. Kolchanov,et al.  Model of the reception of Hedgehog morphogen concentration Gradient: Comparison with an Extended Range of Experimental Data , 2007, J. Bioinform. Comput. Biol..

[10]  J. Taipale,et al.  Patched acts catalytically to suppress the activity of Smoothened , 2002, Nature.

[11]  Tetsuya Tabata,et al.  Morphogens, their identification and regulation , 2004, Development.

[12]  J. Mullor,et al.  A gain-of-function mutant of patched dissects different responses to the hedgehog gradient. , 2000, Developmental biology.

[13]  S. Roth,et al.  The role of brinker in mediating the graded response to Dpp in early Drosophila embryos. , 1999, Development.

[14]  H. Nakagoshi,et al.  Refinement of wingless expression by a wingless- and notch-responsive homeodomain protein, defective proventriculus. , 2002, Developmental biology.

[15]  K. Moses,et al.  The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye , 1993, Cell.

[16]  T. Kornberg,et al.  Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic , 2005, Nature.

[17]  M. Ruiz-Gómez,et al.  groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing. , 1995, Development.

[18]  G. Struhl,et al.  Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein , 2004, Nature.

[19]  James Briscoe,et al.  Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism , 2007, Nature.

[20]  C. Tabin,et al.  Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities , 2004, Cell.

[21]  M. Scott,et al.  Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused , 2005, Development.

[22]  P. Beachy,et al.  Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal , 2001, Science.

[23]  J. Gurdon,et al.  Morphogen gradient interpretation , 2001, Nature.

[24]  Pao-Tien Chuang,et al.  Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein , 1999, Nature.

[25]  N. Méthot,et al.  An absolute requirement for Cubitus interruptus in Hedgehog signaling. , 2001, Development.

[26]  J. Cooke,et al.  Morphogens in vertebrate development: how do they work? , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[27]  S. Bergmann,et al.  Pre-Steady-State Decoding of the Bicoid Morphogen Gradient , 2007, PLoS biology.

[28]  S. Blair,et al.  Engrailed expression in the anterior lineage compartment of the developing wing blade of Drosophila. , 1992, Development.

[29]  T. Belenkaya,et al.  Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process , 2004, Development.

[30]  David H. Sharp,et al.  Dynamic control of positional information in the early Drosophila embryo , 2004, Nature.

[31]  H. Meinhardt,et al.  Space-dependent cell determination under the control of morphogen gradient. , 1978, Journal of theoretical biology.

[32]  C. Tickle,et al.  A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. , 2000, Development.

[33]  A. McMahon,et al.  Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1 , 2004, Development.

[34]  M. Strigini,et al.  A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. , 1997, Development.

[35]  J. Mullor,et al.  Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning. , 1997, Development.

[36]  G. Struhl,et al.  Dual Roles for Patched in Sequestering and Transducing Hedgehog , 1996, Cell.

[37]  Suzanne Eaton,et al.  Lipoprotein particles are required for Hedgehog and Wingless signalling , 2005, Nature.

[38]  J. Gurdon,et al.  Cells’ Perception of Position in a Concentration Gradient , 1998, Cell.

[39]  Krishanu Saha,et al.  Signal dynamics in Sonic hedgehog tissue patterning , 2006, Development.

[40]  A. Kicheva,et al.  The Decapentaplegic morphogen gradient: a precise definition. , 2008, Current opinion in cell biology.

[41]  D. Schaffer,et al.  The sonic hedgehog signaling system as a bistable genetic switch. , 2004, Biophysical journal.

[42]  B. Biehs,et al.  The Drosophila short gastrulation gene prevents Dpp from autoactivating and suppressing neurogenesis in the neuroectoderm. , 1996, Genes & development.

[43]  Alain Vincent,et al.  The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing , 1999, Current Biology.

[44]  Chi-Chung Hui,et al.  Hedgehog signaling in development and cancer. , 2008, Developmental cell.

[45]  L Wolpert,et al.  Thresholds in development. , 1977, Journal of theoretical biology.

[46]  D. Kalderon,et al.  Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction , 2005, Nature Cell Biology.

[47]  Konrad Basler,et al.  Hedgehog Controls Limb Development by Regulating the Activities of Distinct Transcriptional Activator and Repressor Forms of Cubitus interruptus , 1999, Cell.

[48]  S. Cohen,et al.  Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened , 2000, Cell.

[49]  R. Holmgren,et al.  Cubitus interruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer. , 1999, Development.

[50]  Liping Luo,et al.  Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I , 2004, Nature.