Characteristics of macroscopic sleep structure in patients with mild cognitive impairment: a systematic review

Objectives Conducting a systematic analysis of objective measurement tools to assess the characteristics of macroscopic sleep architecture in patients with mild cognitive impairment (MCI), amnestic MCI (aMCI), and non-amnestic MCI (naMCI) in order to provide sleep disorder guidance for MCI patients. Methods PubMed, EMbase, Web of Science, Cochrane Library, CNKI, SinoMed, Wanfang Data, and VIP Data were examined to find literature relating to sleep in patients with MCI, aMCI, and naMCI, with a search time frame of build to April 2023. Following independent literature screening, data extraction, and quality evaluation by two researchers, statistical analysis was performed using RevMan 5.4 software. Results Twenty-five papers with 1,165 study subjects were included. Patients with MCI and aMCI were found to have altered total sleep time (TST), reduced sleep efficiency (SE), more wake-time after sleep onset (WASO), longer sleep latency (SL), a higher proportion of N1 stage and a lower proportion of N2 and N3 stage. naMCI was only found to have statistically significant differences in WASO. Conclusions The results of this study provide evidence for macroscopic sleep architecture abnormalities among MCI patients with sleep disorders. Maintaining a normal sleep time, improving SE, and reducing sleep fragmentation may have an association with a slowed development of cognitive impairment. Further exploration is required of the effects each component of macroscopic sleep structure after the intervention has on altered sleep disturbance and cognition in MCI, aMCI, and naMCI. Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023401937, identifier: CRD42023401937.

[1]  R. Stoohs,et al.  Validity of Two Consumer Multisport Activity Tracker and One Accelerometer against Polysomnography for Measuring Sleep Parameters and Vital Data in a Laboratory Setting in Sleep Patients , 2022, Sensors.

[2]  E. V. van Someren,et al.  Actigraphy in studies on insomnia: Worth the effort? , 2022, Journal of sleep research.

[3]  T. Taoka,et al.  Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease , 2022, Neurology.

[4]  L. Sanford,et al.  Sleep in multiple sclerosis: a systematic review and meta-analysis of polysomnographic findings. , 2022, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[5]  A. Irimie,et al.  Endoglin (CD105) as a putative prognostic biomarker for colorectal cancer: a systematic review , 2022, Medicine and pharmacy reports.

[6]  L. Sanford,et al.  Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings , 2022, Translational Psychiatry.

[7]  Daniel J Buysse,et al.  Comparing polysomnography, actigraphy, and sleep diary in the home environment: The Study of Women’s Health Across the Nation (SWAN) Sleep Study , 2022, Sleep advances : a journal of the Sleep Research Society.

[8]  G. Santangelo,et al.  Apathy and depression in amnestic and non-amnestic mild cognitive impairment , 2022, Journal of clinical and experimental neuropsychology.

[9]  Laura D. Lewis,et al.  A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state , 2021, bioRxiv.

[10]  A. Goldstein-Piekarski,et al.  Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging. , 2021, JAMA neurology.

[11]  S. Feinsilver.  Normal and Abnormal Sleep in the Elderly. , 2021, Clinics in geriatric medicine.

[12]  M. Silvestrini,et al.  Sleep actigraphic patterns and cognitive status. , 2021, Journal of integrative neuroscience.

[13]  Jiangwei Sun,et al.  Association of changes in self-reported sleep duration with mild cognitive impairment in the elderly: a longitudinal study , 2021, Aging.

[14]  Wei Zhang,et al.  Acupuncture for Mild Cognitive Impairment and Dementia: An Overview of Systematic Reviews , 2021, Frontiers in Aging Neuroscience.

[15]  M. Gorgoni,et al.  Sleep-Based Interventions in Alzheimer’s Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory , 2021, Pharmaceuticals.

[16]  E. Mayo-Wilson,et al.  The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. , 2021, Journal of clinical epidemiology.

[17]  K. Cote,et al.  Contributions of post-learning REM and NREM sleep to memory retrieval. , 2021, Sleep medicine reviews.

[18]  Jingling Liao,et al.  Characteristics of Sleep Structure Assessed by Objective Measurements in Patients With Amnestic Mild Cognitive Impairment: A Meta-Analysis , 2020, Frontiers in Neurology.

[19]  Guichen Li,et al.  Sleep Quality and Health-Related Quality of Life in Older People With Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer Disease. , 2020, The Journal of nervous and mental disease.

[20]  Guihua Xu,et al.  Acupuncture for mild cognitive impairment in elderly people , 2020, Medicine.

[21]  E. Mayo-Wilson,et al.  The PRISMA 2020 statement: an updated guideline for reporting systematic reviews , 2020, BMJ.

[22]  P. Elliott,et al.  Sleep, major depressive disorder, and Alzheimer disease , 2020, Neurology.

[23]  A. Bertone,et al.  Modulation of Slow-Wave Sleep: Implications for Psychiatry , 2020, Current Psychiatry Reports.

[24]  N. Marshall,et al.  Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis. , 2020, Sleep medicine reviews.

[25]  Desta Fekedulegn,et al.  Actigraphy-Based Assessment of Sleep Parameters. , 2020, Annals of work exposures and health.

[26]  Ivy Y. Chen,et al.  Characterizing Behavioral Activity Rhythms in Older Adults Using Actigraphy , 2020, Sensors.

[27]  N. Fountoulakis,et al.  Associations between sleep duration and cognitive impairment in mild cognitive impairment , 2019, Journal of sleep research.

[28]  Junhao Pan,et al.  Sleep spindles, K-complexes, limb movements and sleep stage proportions may be biomarkers for amnestic mild cognitive impairment and Alzheimer’s disease , 2019, Sleep and Breathing.

[29]  Junhao Pan,et al.  Spontaneous K-Complexes may be biomarkers of the progression of amnestic mild cognitive impairment. , 2019, Sleep medicine.

[30]  E. Bonanni,et al.  A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease , 2019, Journal of sleep research.

[31]  M. Pihlsgård,et al.  Prevalence and Incidence of Mild Cognitive Impairment across Subtypes, Age, and Sex , 2019, Dementia and Geriatric Cognitive Disorders.

[32]  R. Gruber,et al.  Can Slow-Wave Sleep Enhancement Improve Memory? A Review of Current Approaches and Cognitive Outcomes , 2019, The Yale journal of biology and medicine.

[33]  A. Halbower,et al.  Polysomnography. , 2018, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[34]  Daniel J Buysse,et al.  Sleep moderates the relationship between amyloid beta and memory recall , 2018, Neurobiology of Aging.

[35]  K. Yaremchuk.  Sleep Disorders in the Elderly. , 2018, Clinics in geriatric medicine.

[36]  J. Gagné.  Literature Review , 2018, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[37]  S. Ryu,et al.  Sleep and cognitive decline: A prospective nondemented elderly cohort study , 2018, Annals of neurology.

[38]  M. Delgado-Rodríguez,et al.  Systematic review and meta-analysis. , 2017, Medicina intensiva.

[39]  G. Wilcock,et al.  Sleep-Wake Patterns and Cognition of Older Adults with Amnestic Mild Cognitive Impairment (aMCI): A Comparison with Cognitively Healthy Adults and Moderate Alzheimer's Disease Patients. , 2017, Current Alzheimer research.

[40]  N. Gosselin,et al.  Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment. , 2017, Sleep medicine.

[41]  P. Rossini,et al.  In Search of Sleep Biomarkers of Alzheimer’s Disease: K-Complexes Do Not Discriminate between Patients with Mild Cognitive Impairment and Healthy Controls , 2017, Brain sciences.

[42]  Yongfei Tan,et al.  Sleep disturbance in mild cognitive impairment: a systematic review of objective measures , 2017, Neurological Sciences.

[43]  E. Mori,et al.  Sleep disturbances are key symptoms of very early stage Alzheimer disease with behavioral and psychological symptoms: a Japan multi‐center cross‐sectional study (J‐BIRD) , 2017, International journal of geriatric psychiatry.

[44]  N. Gosselin,et al.  Quantitative EEG of Rapid-Eye-Movement Sleep , 2016, Clinical EEG and neuroscience.

[45]  N. Mercuri,et al.  Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer's disease , 2016, Neurobiology of Aging.

[46]  P. Rossini,et al.  Parietal Fast Sleep Spindle Density Decrease in Alzheimer's Disease and Amnesic Mild Cognitive Impairment , 2016, Journal of Neural Transplantation and Plasticity.

[47]  M. Hirshkowitz,et al.  National Sleep Foundation's updated sleep duration recommendations: final report. , 2015, Sleep health.

[48]  Enrica Bonanni,et al.  Non-rapid eye movement sleep instability in mild cognitive impairment: a pilot study. , 2015, Sleep medicine.

[49]  K. Langa,et al.  The diagnosis and management of mild cognitive impairment: a clinical review. , 2014, JAMA.

[50]  Mercedes Atienza,et al.  Sleep deficits in mild cognitive impairment are related to increased levels of plasma amyloid-β and cortical thinning , 2014, NeuroImage.

[51]  James Robert Brašić,et al.  Objectively measured sleep and β-amyloid burden in older adults: A pilot study , 2014, SAGE open medicine.

[52]  Misha Pavel,et al.  Sleep Habits in Mild Cognitive Impairment , 2014, Alzheimer disease and associated disorders.

[53]  S. Redline,et al.  Associations of objectively and subjectively measured sleep quality with subsequent cognitive decline in older community-dwelling men: the MrOS sleep study. , 2014, Sleep.

[54]  S. Naismith,et al.  Screening for Sleep Apnoea in Mild Cognitive Impairment: The Utility of the Multivariable Apnoea Prediction Index , 2014, Sleep disorders.

[55]  I. Hickie,et al.  Circadian misalignment and sleep disruption in mild cognitive impairment. , 2013, Journal of Alzheimer's disease : JAD.

[56]  J. L. Cantero,et al.  Polysomnographic and subjective sleep markers of mild cognitive impairment. , 2013, Sleep.

[57]  C. Jack,et al.  Mild cognitive impairment due to Alzheimer disease in the community , 2013, Annals of neurology.

[58]  Mercedes Atienza,et al.  Disturbed sleep patterns in elders with mild cognitive impairment: the role of memory decline and ApoE ε4 genotype. , 2012, Current Alzheimer research.

[59]  J. Clarke,et al.  What is a systematic review? , 2011, Evidence Based Nursing.

[60]  J. Morris,et al.  The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[61]  Nick C Fox,et al.  The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[62]  D. Y. Lee,et al.  Neurocognitive dysfunction associated with sleep quality and sleep apnea in patients with mild cognitive impairment. , 2011, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[63]  Carmen E. Westerberg,et al.  Sleep Influences the Severity of Memory Disruption in Amnestic Mild Cognitive Impairment: Results From Sleep Self-assessment and Continuous Activity Monitoring , 2010, Alzheimer disease and associated disorders.

[64]  Chaur-Jong Hu,et al.  Expression of inducible nitric oxide synthase (iNOS) and period 1 (PER1) clock gene products in different sleep stages of patients with cognitive impairment , 2010, Journal of Clinical Neuroscience.

[65]  A. Stang.  Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses , 2010, European Journal of Epidemiology.

[66]  Chaur-Jong Hu,et al.  Low sleep efficiency in patients with cognitive impairment. , 2009, Acta neurologica Taiwanica.

[67]  P. Leffers,et al.  An Overview of Systematic Reviews , 2009 .

[68]  S. Ancoli-Israel,et al.  Sleep disturbances in long-term care. , 2008, Clinics in geriatric medicine.

[69]  F. Schmidt.  Meta-Analysis , 2008 .

[70]  P. Scheltens,et al.  Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[71]  J. Morris,et al.  Mild cognitive impairment as a clinical entity and treatment target. , 2005, Archives of neurology.

[72]  C. Guilleminault,et al.  Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. , 2004, Sleep.

[73]  R. Petersen.  Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[74]  C. Jack,et al.  Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment , 2004, Journal of internal medicine.

[75]  Ronald C Petersen,et al.  Mild Cognitive Impairment. , 2004, Continuum.

[76]  E. Bixler,et al.  Insomnia in central Pennsylvania. , 2002, Journal of psychosomatic research.

[77]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[78]  C. Baird.  The pilot study. , 2000, Orthopedic nursing.

[79]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[80]  R. Petersen,et al.  Aging, Memory, and Mild Cognitive Impairment , 1997, International Psychogeriatrics.

[81]  M. Zaudig,et al.  A New Systematic Method of Measurement and Diagnosis of “Mild Cognitive Impairment” and Dementia According to ICD-10 and DSM-III-R Criteria , 1992, International Psychogeriatrics.

[82]  B. Reisberg,et al.  Mild cognitive impairment in the elderly , 1991, Neurology.

[83]  W. B. Webb,et al.  A modified method for scoring slow wave sleep of older subjects. , 1982, Sleep.

[84]  G. Fraedrich,et al.  Juvenile recurrent respiratory papillomatosis: Still a mystery disease with difficult management , 2007, Head & neck.

[85]  L. Velayudhan,et al.  Neuropsychiatric Symptoms in Mild Cognitive Impairment: A Literature Review , 2020, Dementia and Geriatric Cognitive Disorders.

[86]  R. Mehra,et al.  Practical aspects of actigraphy and approaches in clinical and research domains. , 2019, Handbook of clinical neurology.

[87]  T. Lam,et al.  Sleep quality and cognitive impairment in older Chinese: Guangzhou Biobank Cohort Study. , 2019, Age and ageing.

[88]  I. Hickie,et al.  Association between Sleep-Disordered Breathing and Neuropsychological Performance in Older Adults with Mild Cognitive Impairment. , 2015, Journal of Alzheimer's disease : JAD.

[89]  Maja O’Connor.  LONGITUDINAL STUDY , 2013 .

[90]  A. Chesson,et al.  The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Techinical Specifications , 2007 .

[91]  John Stivoric,et al.  Armband as a Sleep Detection Device , 2002 .

[92]  Daniel R. Miller,et al.  Final report , 2000 .

[93]  C. Guilleminault,et al.  EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. , 1992, Sleep.

[94]  B. Reisberg,et al.  Stage‐specific behavioral, cognitive, and in vivo changes in community residing subjects with age‐associated memory impairment and primary degenerative dementia of the Alzheimer type , 1988 .

[95]  O. Franco,et al.  Mendelian Randomization Causal Analysis LDL cholesterol still a problem in old age? A Mendelian randomization study , 2015 .