Structure of antibody-antigen complexes: implications for immune recognition.

[1]  R. Webster,et al.  Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A. , 1988, Journal of molecular biology.

[2]  H. Clevers,et al.  Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[3]  B C Finzel,et al.  Three-dimensional structure of an antibody-antigen complex. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[4]  M. A. Saper,et al.  The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens , 1987, Nature.

[5]  M. A. Saper,et al.  Structure of the human class I histocompatibility antigen, HLA-A2 , 1987, Nature.

[6]  M. Oldstone Molecular mimicry and autoimmune disease , 1987, Cell.

[7]  G. Air,et al.  Antigenic structure and variation in an influenza virus N9 neuraminidase , 1987, Journal of virology.

[8]  A. Lesk,et al.  Canonical structures for the hypervariable regions of immunoglobulins. , 1987, Journal of molecular biology.

[9]  J. C. Cheetham,et al.  Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering , 1987, Nature.

[10]  R. M. Burnett,et al.  Biological Organization: Macromolecular Interactions at High Resolution , 1987 .

[11]  B. Alarcón,et al.  The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[12]  C. Milstein,et al.  Mutation Drift and Repertoire Shift in the Maturation of the Immune Response , 1987, Immunological reviews.

[13]  S J Rodda,et al.  Mechanisms of antibody binding to a protein. , 1987, Science.

[14]  R. Lerner,et al.  Chemistry of antibody binding to a protein. , 1987, Science.

[15]  P. Bartlett,et al.  Evaluation of intrinsic binding energy from a hydrogen bonding group in an enzyme inhibitor. , 1987, Science.

[16]  H M Holden,et al.  Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond. , 1987, Science.

[17]  A. Boodhoo,et al.  Crystallization and structure determination of an autoimmune anti-poly(dT) immunoglobulin Fab fragment at 3.0 A resolution. , 1987, The Journal of biological chemistry.

[18]  L. Hood,et al.  Diversity and structure of human T-cell receptor alpha-chain variable region genes. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[19]  G. Air,et al.  Three‐dimensional structure of neuraminidase of subtype N9 from an avian influenza virus , 1987, Proteins.

[20]  Crystals of antibodies complexed with influenza virus neuraminidase show isosteric binding of antibody to wild-type and variant antigens. , 1987, Virology.

[21]  E. Morgan,et al.  Biological activities residing in the Fc region of immunoglobulin. , 1987, Advances in immunology.

[22]  Cyrus Chothia,et al.  The accessible surface area and stability of oligomeric proteins , 1987, Nature.

[23]  J. N. Varghese,et al.  Three-dimensional structure of a complex of antibody with influenza virus neuraminidase , 1987, Nature.

[24]  How antibodies recognize virus proteins. , 1987, Immunology today.

[25]  F. Alt,et al.  A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes , 1986, Nature.

[26]  G. Cohen,et al.  Antibody Fab assembly: the interface residues between CH1 and CL. , 1986, Molecular immunology.

[27]  M Levitt,et al.  The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure , 1986, Science.

[28]  R. Poljak,et al.  Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution , 1986, Science.

[29]  J. Seidman,et al.  Identification of a putative second T-cell receptor , 1986, Nature.

[30]  J. Coligan,et al.  Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex , 1986, Nature.

[31]  C. Levinthal,et al.  Predicting antibody hypervariable loop conformations II: Minimization and molecular dynamics studies of MCPC603 from many randomly generated loop conformations , 1986, Proteins.

[32]  A. McMichael,et al.  The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides , 1986, Cell.

[33]  S. Tonegawa,et al.  Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[34]  A. D. McLachlan,et al.  Solvation energy in protein folding and binding , 1986, Nature.

[35]  M. Buchmeier,et al.  Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues , 1986, Journal of virology.

[36]  T. Bhat,et al.  The galactan‐binding immunoglobulin Fab J539: An x‐ray diffraction study at 2.6‐Å resolution , 1986, Proteins.

[37]  Y. Satow,et al.  Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A. , 1985, Journal of molecular biology.

[38]  L. Hood,et al.  The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. , 1986, Annual review of immunology.

[39]  A. Weiss,et al.  The role of the T3/antigen receptor complex in T-cell activation. , 1986, Annual review of immunology.

[40]  C. Chothia,et al.  Domain association in immunoglobulin molecules. The packing of variable domains. , 1985, Journal of molecular biology.

[41]  D. Filman,et al.  Three-dimensional structure of poliovirus at 2.9 A resolution. , 1985, Science.

[42]  John E. Johnson,et al.  Structure of a human common cold virus and functional relationship to other picornaviruses , 1985, Nature.

[43]  B. Wang,et al.  Novel arrangement of immunoglobulin variable domains: X-ray crystallographic analysis of the lambda-chain dimer Bence-Jones protein Loc. , 1985, Biochemistry.

[44]  J. Novotný,et al.  Structural invariants of antigen binding: comparison of immunoglobulin VL-VH and VL-VL domain dimers. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[45]  A. Lesk,et al.  Helix movements in proteins , 1985 .

[46]  A J Olson,et al.  The atomic mobility component of protein antigenicity. , 1985, Annual review of immunology.

[47]  L. Hood,et al.  Diversity and structure of genes of the α family of mouse T-cell antigen receptor , 1985, Nature.

[48]  Arthur J. Olson,et al.  The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein , 1984, Nature.

[49]  S. Tonegawa,et al.  A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes , 1984, Nature.

[50]  M. Knossow,et al.  Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin , 1984, Nature.

[51]  D. Moras,et al.  Correlation between segmental mobility and the location of antigenic determinants in proteins , 1984, Nature.

[52]  R. Bruccoleri,et al.  Twisted hyperboloid (Strophoid) as a model of beta-barrels in proteins. , 1984, Journal of molecular biology.

[53]  K. R. Ely,et al.  A search for site-filling ligands in the Mcg Bence-Jones dimer: crystal binding studies of fluorescent compounds. , 1984, Molecular immunology.

[54]  A M Lesk,et al.  Mechanisms of domain closure in proteins. , 1984, Journal of molecular biology.

[55]  Mark M. Davis,et al.  Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins , 1984, Nature.

[56]  Tak W. Mak,et al.  A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains , 1984, Nature.

[57]  B. Friguet,et al.  Structural and functional influence of enzyme-antibody interactions: effects of eight different monoclonal antibodies on the enzymatic activity of Escherichia coli tryptophan synthase. , 1984, Biochemistry.

[58]  W. Bennett,et al.  Structural and functional aspects of domain motions in proteins. , 1984, CRC critical reviews in biochemistry.

[59]  J. Berzofsky,et al.  The antigenic structure of proteins: a reappraisal. , 1984, Annual review of immunology.

[60]  S. Orkin,et al.  Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex , 1984, Nature.

[61]  M Karplus,et al.  Molecular anatomy of the antibody binding site. , 1983, The Journal of biological chemistry.

[62]  H. Grey,et al.  Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing , 1983, The Journal of experimental medicine.

[63]  W Furey,et al.  Structure of a novel Bence-Jones protein (Rhe) fragment at 1.6 A resolution. , 1983, Journal of molecular biology.

[64]  J. N. Varghese,et al.  Structure of the catalytic and antigenic sites in influenza virus neuraminidase , 1983, Nature.

[65]  J. N. Varghese,et al.  Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution , 1983, Nature.

[66]  S. Tonegawa Somatic generation of antibody diversity , 1983, Nature.

[67]  Cyrus Chothia,et al.  Transmission of conformational change in insulin , 1983, Nature.

[68]  P. Marrack,et al.  The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody , 1983, The Journal of experimental medicine.

[69]  E. Reinherz,et al.  Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex , 1983, The Journal of experimental medicine.

[70]  D. Davies,et al.  Structural basis of antibody function. , 1983, Annual review of immunology.

[71]  R. Huber,et al.  Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 A resolution. , 1984, Journal of molecular biology.

[72]  J Deisenhofer,et al.  The three-dimensional structure of antibodies. , 1983, Immunology today.

[73]  J. Allison,et al.  Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody. , 1982, Journal of immunology.

[74]  A M Lesk,et al.  Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains. , 1982, Journal of molecular biology.

[75]  C. Chothia,et al.  Orthogonal packing of beta-pleated sheets in proteins. , 1982, Biochemistry.

[76]  M. Lilley,et al.  Is the CH4, H2 and CO venting from submarine hydrothermal systems produced by thermophilic bacteria? , 1982 .

[77]  J. Schwartz,et al.  Glycogenolysis induced by serotonin in brain: identification of a new class of receptor , 1982, Nature.

[78]  A. Wilson,et al.  Mapping the antigenic epitope for a monoclonal antibody against lysozyme. , 1982, Journal of immunology.

[79]  R. Zidovetzki,et al.  A heterologous immunoglobulin chain recombinant carries a distinct site for dinitrophenyl and obeys the common hapten binding mechanism. , 1981, Biochemistry.

[80]  C. Chothia,et al.  Relative orientation of close-packed beta-pleated sheets in proteins. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[81]  William R. Taylor,et al.  Analysis of the tertiary structure of protein β-sheet sandwiches , 1981 .

[82]  I. Wilson,et al.  Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation , 1981, Nature.

[83]  I. Wilson,et al.  Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution , 1981, Nature.

[84]  J. Richardson,et al.  The anatomy and taxonomy of protein structure. , 1981, Advances in protein chemistry.

[85]  J Deisenhofer,et al.  Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 A and 1.0 A resolution. , 1980, Journal of molecular biology.

[86]  A. Efimov Packing of α-helices in globular proteins. Layer-structure of globin hydrophobic cores , 1979 .

[87]  Evaluation of the structural variation among light chain variable domains. , 1979, Molecular immunology.

[88]  R. Poljak,et al.  Three-dimensional structure of immunoglobulins. , 1979, Annual review of biochemistry.

[89]  L M Amzel,et al.  Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution. , 1981, The Journal of biological chemistry.

[90]  M. Atassi Precise determination of the entire antigenic structure of lysozyme: molecular features of protein antigenic structures and potential of "surface-simulation" synthesis--a powerful new concept for protein binding sites. , 1978, Immunochemistry.

[91]  W. Gerhard,et al.  Antigenic drift in influenza A viruses. I. Selection and characterization of antigenic variants of A/PR/8/34 [HON1] influenza virus with monoclonal antibodies , 1978, The Journal of experimental medicine.

[92]  R. Huber,et al.  Crystal structure of the human Fab fragment Kol and its comparison with the intact Kol molecule. , 1978, Journal of molecular biology.

[93]  J. Richardson,et al.  The beta bulge: a common small unit of nonrepetitive protein structure. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[94]  Frederic M. Richards,et al.  Packing of α-helices: Geometrical constraints and contact areas☆ , 1978 .

[95]  K. R. Ely,et al.  Crystal properties as indicators of conformational changes during ligand binding or interconversion of Mcg light chain isomers. , 1978, Biochemistry.

[96]  E. Kabat,et al.  The Structural Basis for Antibody Complementary , 1978 .

[97]  H. Metzger,et al.  The effect of antigen on antibodies: recent studies. , 1978, Contemporary topics in molecular immunology.

[98]  P. Colman,et al.  Crystal and molecular structure of the dimer of variable domains of the Bence-Jones protein ROY. , 1977, Journal of molecular biology.

[99]  C. Chothia,et al.  Structure of proteins: packing of alpha-helices and pleated sheets. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[100]  G J Williams,et al.  The Protein Data Bank: a computer-based archival file for macromolecular structures. , 1977, Journal of molecular biology.

[101]  D. Lancet,et al.  Kinetic evidence for hapten-induced conformational transition in immunoglobin MOPC 460. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[102]  D. Mercola,et al.  Structure of insulin in 4-zinc insulin , 1976, Nature.

[103]  J Deisenhofer,et al.  Structure of the human antibody molecule Kol (immunoglobulin G1): an electron density map at 5 A resolution. , 1976, Journal of molecular biology.

[104]  W. Bode,et al.  The refined crystal structure of bovine beta-trypsin at 1.8 A resolution. II. Crystallographic refinement, calcium binding site, benzamidine binding site and active site at pH 7.0. , 1975, Journal of molecular biology.

[105]  C. Chothia,et al.  Principles of protein–protein recognition , 1975, Nature.

[106]  A. N. Hicks,et al.  Fluorescence polarization and intensity kinetic studies of antifluorescein antibody obtained at different stages of the immune response. , 1975, Biochemistry.

[107]  I. Z. Steinberg,et al.  Antigen-induced conformational changes in antibodies and their Fab fragments studied by circular polarization of fluorescence. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[108]  M. Atassi,et al.  Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins. , 1975, Immunochemistry.

[109]  C. Chothia Structural invariants in protein folding , 1975, Nature.

[110]  E. Padlan,et al.  Three-dimensional structure of immunoglobulins. , 1975, Annual review of biochemistry.

[111]  G. Cohen,et al.  The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[112]  J Deisenhofer,et al.  Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution. , 1974, Journal of molecular biology.

[113]  R. Huber,et al.  Crystal and molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI. , 1974, European journal of biochemistry.

[114]  R. Zinkernagel,et al.  Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system , 1974, Nature.

[115]  L M Amzel,et al.  The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[116]  C. Chothia,et al.  Hydrophobic bonding and accessible surface area in proteins , 1974, Nature.

[117]  E. Padlan,et al.  Structure at 4.5 A resolution of a phosphorylcholine-binding fab. , 1973, Nature: New biology.

[118]  W. Konigsberg,et al.  Speculations. How specific are antibodies? , 1973, Immunochemistry.

[119]  K. R. Ely,et al.  Structure of a lambda-type Bence-Jones protein at 3.5-A resolution. , 1972, Biochemistry.

[120]  E. Haber,et al.  Changes in intrinsic circular dichroism of several homogeneous anti-type 3 pneumococcal antibodies on binding of a small hapten. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[121]  T. Blundell,et al.  Atomic Positions in Rhombohedral 2-Zinc Insulin Crystals , 1971, Nature.

[122]  G. Edelman,et al.  The antibody problem. , 1969, Annual review of biochemistry.

[123]  W. Kauzmann Some factors in the interpretation of protein denaturation. , 1959, Advances in protein chemistry.

[124]  F. Crick,et al.  The packing of α‐helices: simple coiled‐coils , 1953 .

[125]  L. Pauling Chemical achievement and hope for the future. , 1948, American scientist.

[126]  P. Ehrlich,et al.  Croonian lecture.—On immunity with special reference to cell life , 1900, Proceedings of the Royal Society of London.

[127]  E. Fischer Einfluss der Configuration auf die Wirkung der Enzyme , 1894 .