论文信息 - RANKL expression in a case of follicular lymphoma

RANKL expression in a case of follicular lymphoma

Abstract: The TNF‐family molecule, RANKL, is a key regulator of bone remodeling and essential for the development and activation of osteoclasis. Bone involvement signals diesease activity in non‐Hodgkin's lymphoma and influences the progenesis. The molecular mechanism and soluble factors involved in osteoclastic activation in haematological malignancies remain unclear except for Multiple Myeloma and Adult T‐cell Leukemia. The aim of this paper is to report the first case of Follicular Lymphoma with bone involvement displaying an aberrant expression of RANKL in malignant cells. The detection of RANKL in Follicullar Lymphoma may help to prevent bone lesion in patients by determining an appropriate treatment.

[1] O. Sezer,et al. Immunocytochemistry reveals RANKL expression of myeloma cells. , 2002, Blood.

[2] E. Milgrom,et al. RANK (receptor activator of nuclear factor‐κB) and RANKL expression in multiple myeloma , 2002, British journal of haematology.

[3] M. Matsuoka,et al. Mechanism of hypercalcemia in adult T-cell leukemia: overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. , 2002, Blood.

[4] R. Bataille,et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. , 2001, Blood.

[5] J. Michaeli,et al. Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6] S. Morony,et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis , 1999, Nature.

[7] O. Sezer,et al. Human bone marrow myeloma cells express RANKL. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8] J. Penninger,et al. RANK-L and RANK: T cells, bone loss, and mammalian evolution. , 2002, Annual review of immunology.