Pharmaceuticals and iodinated contrast media in a hospital wastewater: A case study to analyse their presence and characterise their environmental risk and hazard.

[1]  D. Barceló,et al.  Cytostatic drugs and metabolites in municipal and hospital wastewaters in Spain: filtration, occurrence, and environmental risk. , 2014, The Science of the total environment.

[2]  D. Barceló,et al.  Hospital wastewater treatment by fungal bioreactor: removal efficiency for pharmaceuticals and endocrine disruptor compounds. , 2014, The Science of the total environment.

[3]  S. Lacorte,et al.  Occurrence of cytostatic compounds in hospital effluents and wastewaters, determined by liquid chromatography coupled to high-resolution mass spectrometry , 2014, Analytical and Bioanalytical Chemistry.

[4]  D. Barceló,et al.  Assessment of multi-chemical pollution in aquatic ecosystems using toxic units: compound prioritization, mixture characterization and relationships with biological descriptors. , 2014, The Science of the total environment.

[5]  A. Martins,et al.  Determination of anti-anxiety and anti-epileptic drugs in hospital effluent and a preliminary risk assessment. , 2013, Chemosphere.

[6]  M. Lavorgna,et al.  Sildenafil and tadalafil in simulated chlorination conditions: ecotoxicity of drugs and their derivatives. , 2013, The Science of the total environment.

[7]  J. Rivera-Utrilla,et al.  Pharmaceuticals as emerging contaminants and their removal from water. A review. , 2013, Chemosphere.

[8]  Damià Barceló,et al.  Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals. , 2013, The Science of the total environment.

[9]  Francesc Ventura,et al.  Validation and uncertainty estimation of a multiresidue method for pharmaceuticals in surface and treated waters by liquid chromatography-tandem mass spectrometry. , 2013, Journal of chromatography. A.

[10]  A. Schäffer,et al.  Microbial degradation of the pharmaceutical ibuprofen and the herbicide 2,4-D in water and soil - use and limits of data obtained from aqueous systems for predicting their fate in soil. , 2013, The Science of the total environment.

[11]  R. Merlanti,et al.  Sublethal effects of trimethoprim on four freshwater organisms. , 2012, Ecotoxicology and environmental safety.

[12]  D. Barceló,et al.  Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry. , 2012, Journal of chromatography. A.

[13]  P Verlicchi,et al.  Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. , 2012, The Science of the total environment.

[14]  P. Verlicchi,et al.  Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment--a review. , 2012, The Science of the total environment.

[15]  G. Dave,et al.  Determination of detoxification to Daphnia magna of four pharmaceuticals and seven surfactants by activated sludge. , 2012, Chemosphere.

[16]  J. Miñana Utilización de medicamentos en España y en Europa , 2012 .

[17]  Damià Barceló,et al.  New indexes for compound prioritization and complexity quantification on environmental monitoring inventories , 2012, Environmental Science and Pollution Research.

[18]  I. Oller,et al.  Combination of Advanced Oxidation Processes and biological treatments for wastewater decontamination--a review. , 2011, The Science of the total environment.

[19]  B. Quinn,et al.  Effects of the pharmaceuticals gemfibrozil and diclofenac on biomarker expression in the zebra mussel (Dreissena polymorpha) and their comparison with standardised toxicity tests. , 2011, Chemosphere.

[20]  W. Brack,et al.  A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European Water Framework Directive. , 2011, The Science of the total environment.

[21]  J. Giesy,et al.  Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa. , 2010, Aquatic toxicology.

[22]  E. C. Vasconcelos,et al.  Environmental risk assessment of antibiotics: an intensive care unit analysis. , 2009, Chemosphere.

[23]  Vânia Calisto,et al.  Psychiatric pharmaceuticals in the environment. , 2009, Chemosphere.

[24]  Anders Baun,et al.  Probabilistic environmental risk characterization of pharmaceuticals in sewage treatment plant discharges. , 2009, Chemosphere.

[25]  Kevin V Thomas,et al.  Determination of pharmaceutical compounds in hospital effluents and their contribution to wastewater treatment works. , 2009, Environment international.

[26]  Yu-Ting Tsai,et al.  Occurrence of pharmaceuticals in Taiwan's surface waters: impact of waste streams from hospitals and pharmaceutical production facilities. , 2009, The Science of the total environment.

[27]  C. Poltronieri,et al.  The toxicity of sulfamethazine to Daphnia magna and its additivity to other veterinary sulfonamides and trimethoprim. , 2009, Chemosphere.

[28]  Christoph Ort,et al.  Mass flows of X-ray contrast media and cytostatics in hospital wastewater. , 2009, Environmental science & technology.

[29]  Y. Perrodin,et al.  Groundwater contamination by microbiological and chemical substances released from hospital wastewater: health risk assessment for drinking water consumers. , 2009, Environment international.

[30]  Klaus Kümmerer,et al.  Antibiotics in the aquatic environment--a review--part I. , 2009, Chemosphere.

[31]  N. Ichikawa,et al.  Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes). , 2009, The Journal of toxicological sciences.

[32]  S. Costanzo,et al.  The occurrence of antibiotics in an urban watershed: from wastewater to drinking water. , 2009, The Science of the total environment.

[33]  D. Barceló,et al.  Tracing pharmaceutical residues of different therapeutic classes in environmental waters by using liquid chromatography/quadrupole-linear ion trap mass spectrometry and automated library searching. , 2009, Analytical chemistry.

[34]  Francesco Busetti,et al.  Rapid analysis of iodinated X-ray contrast media in secondary and tertiary treated wastewater by direct injection liquid chromatography-tandem mass spectrometry. , 2008, Journal of chromatography. A.

[35]  Cheng-Fang Lin,et al.  Pharmaceutical contamination in residential, industrial, and agricultural waste streams: risk to aqueous environments in Taiwan. , 2008, Chemosphere.

[36]  N. Nakada,et al.  Biological effects of PPCPs on aquatic lives and evaluation of river waters affected by different wastewater treatment levels. , 2008, Water science and technology : a journal of the International Association on Water Pollution Research.

[37]  E. Cooper,et al.  Preliminary risk assessment database and risk ranking of pharmaceuticals in the environment. , 2008, The Science of the total environment.

[38]  Barbara Kasprzyk-Hordern,et al.  The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. , 2008, Water research.

[39]  G. Ying,et al.  Growth‐inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga Pseudokirchneriella subcapitata , 2008, Environmental toxicology and chemistry.

[40]  Matthew J Winter,et al.  Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas). , 2008, Aquatic toxicology.

[41]  Martin Schlabach,et al.  Source to sink tracking of selected human pharmaceuticals from two Oslo city hospitals and a wastewater treatment works. , 2007, Journal of environmental monitoring : JEM.

[42]  Maria Rubino,et al.  Toxic and genotoxic impact of fibrates and their photoproducts on non-target organisms. , 2007, Environment international.

[43]  Kyungho Choi,et al.  Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. , 2007, Environment international.

[44]  Max Maurer,et al.  Elimination of β-blockers in sewage treatment plants , 2007 .

[45]  J. Straub,et al.  Deterministic and probabilistic acute‐based environmental risk assessment for naproxen for Western Europe , 2007, Environmental toxicology and chemistry.

[46]  D. Barceló,et al.  Fate and occurrence of X-ray contrast media in the environment , 2007, Analytical and bioanalytical chemistry.

[47]  A. M. Christensen,et al.  Mixture and single‐substance toxicity of selective serotonin reuptake inhibitors toward algae and crustaceans , 2007, Environmental toxicology and chemistry.

[48]  D. Mawhinney,et al.  Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. , 2006, The Science of the total environment.

[49]  D. Barceló,et al.  Determination of pharmaceuticals of various therapeutic classes by solid-phase extraction and liquid chromatography-tandem mass spectrometry analysis in hospital effluent wastewaters. , 2006, Journal of chromatography. A.

[50]  M. Isidori,et al.  A multispecies study to assess the toxic and genotoxic effect of pharmaceuticals: furosemide and its photoproduct. , 2006, Chemosphere.

[51]  N. Nakada,et al.  Effects of antibacterial agents, levofloxacin and clarithromycin, on aquatic organisms. , 2006, Water science and technology : a journal of the International Association on Water Pollution Research.

[52]  B. Brooks,et al.  Physiological and Reproductive Effects of Beta Adrenergic Receptor Antagonists in Daphnia magna , 2006, Archives of environmental contamination and toxicology.

[53]  D. Calamari,et al.  Effects of a complex mixture of therapeutic drugs at environmental levels on human embryonic cells. , 2006, Environmental science & technology.

[54]  K. Fent,et al.  Ecotoxicology of human pharmaceuticals. , 2006, Aquatic toxicology.

[55]  H. Hur,et al.  Ecotoxicological risk of pharmaceuticals from wastewater treatment plants in Korea: Occurrence and toxicity to Daphnia magna , 2006, Environmental toxicology and chemistry.

[56]  D. Dietrich,et al.  Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). , 2005, Aquatic toxicology.

[57]  J. Garric,et al.  Prediction and experimental validation of acute toxicity of β‐blockers in Ceriodaphnia dubia , 2005 .

[58]  Maria Rubino,et al.  Ecotoxicity of naproxen and its phototransformation products. , 2005, The Science of the total environment.

[59]  F. Carvalho,et al.  Acute toxicity of widely used pharmaceuticals in aquatic species: Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii. , 2005, Ecotoxicology and environmental safety.

[60]  Å. Wennmalm,et al.  Public Health Care Management of Water Pollution with Pharmaceuticals: Environmental Classification and Analysis of Pharmaceutical Residues in Sewage Water , 2005 .

[61]  M. Lavorgna,et al.  Toxic and genotoxic evaluation of six antibiotics on non-target organisms. , 2005, The Science of the total environment.

[62]  Adriano Joss,et al.  Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment. , 2005, Environmental science & technology.

[63]  Mats Tysklind,et al.  Determination of antibiotic substances in hospital sewage water using solid phase extraction and liquid chromatography/mass spectrometry and group analogue internal standards. , 2004, Chemosphere.

[64]  K. Armbrust,et al.  Acute and chronic toxicity of five selective serotonin reuptake inhibitors in Ceriodaphnia dubia , 2004, Environmental toxicology and chemistry.

[65]  D. Barceló,et al.  Analysis by liquid chromatography-electrospray ionization tandem mass spectrometry and acute toxicity evaluation for beta-blockers and lipid-regulating agents in wastewater samples. , 2004, Journal of chromatography. A.

[66]  G. Huschek,et al.  Environmental risk assessment of medicinal products for human use according to European Commission recommendations , 2004, Environmental toxicology.

[67]  A. Pollio,et al.  Environmental risk assessment of six human pharmaceuticals: Are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment? , 2004, Environmental toxicology and chemistry.

[68]  A. Pollio,et al.  Erratum to “Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac”: [Ecotoxicol. Environ. Saf. 55 (2003) 359–370] , 2003 .

[69]  R. Brain,et al.  Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening. , 2003, Toxicology letters.

[70]  A. Pollio,et al.  Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. , 2003, Ecotoxicology and environmental safety.

[71]  M. Cleuvers Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. , 2003, Toxicology letters.

[72]  B. Brooks,et al.  Toxicity of Select Beta Adrenergic Receptor-Blocking Pharmaceuticals (B-Blockers) on Aquatic Organisms , 2002, Archives of environmental contamination and toxicology.

[73]  K. Kümmerer Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources--a review. , 2001, Chemosphere.

[74]  M. Jekel,et al.  OCCURRENCE OF IODINATED X-RAY CONTRAST MEDIA IN DOMESTIC EFFLUENTS AND THEIR FATE DURING INDIRECT POTABLE REUSE , 2001, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[75]  Thomas A. Ternes,et al.  Occurrence and behavior of X-ray contrast media in sewage facilities and the aquatic environment , 2000 .

[76]  T. Ternes,et al.  A sensitive method for the determination of iodine containing diagnostic agents in aqueous matrices using LC-electrospray-tandem-MS detection , 2000, Fresenius' journal of analytical chemistry.

[77]  T. Ternes,et al.  Pharmaceuticals and personal care products in the environment: agents of subtle change? , 1999, Environmental health perspectives.

[78]  Rebecca A. Efroymson,et al.  Ecological risk assessment in a large river‐reservoir: 3. Benthic invertebrates , 1999 .

[79]  T. Ternes Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus , 1998 .

[80]  F. Sörgel,et al.  Urinary bactericidal activity and pharmacokinetics of enoxacin versus norfloxacin and ciprofloxacin in healthy volunteers after a single oral dose , 1998 .

[81]  A Wenzel,et al.  Environmental hazard assessment of pharmaceuticals. , 1997, Regulatory toxicology and pharmacology : RTP.

[82]  V. Hormazábal,et al.  Persistence of antibacterial agents in marine sediments , 1995 .

[83]  P. Geladi,et al.  The Predictive Potential of a Battery of Ecotoxicological Tests for Human Acute Toxicity, as Evaluated with the First 50 MEIC Chemicals , 1993 .

[84]  Y. Perrodin,et al.  A posteriori assessment of ecotoxicological risks linked to building a hospital. , 2016, Chemosphere.

[85]  L. Angnes Pharmaceuticals and Personal Care Products , 2015 .

[86]  Karin Treyer,et al.  Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater. , 2011, Water research.

[87]  Sun-Kyoung Shin,et al.  Occurrence and distribution of pharmaceuticals in wastewater from households, livestock farms, hospitals and pharmaceutical manufactures. , 2011, Chemosphere.

[88]  Despo Fatta-Kassinos,et al.  Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research , 2011, Analytical and bioanalytical chemistry.

[89]  D. Barceló,et al.  Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. , 2010, Environment international.

[90]  J. Tarazona,et al.  Occurrence of pharmaceutically active compounds in surface waters of the Henares-Jarama-Tajo River system (Madrid, Spain) and a potential risk characterization. , 2010, The Science of the total environment.

[91]  J. Sekizawa,et al.  Initial ecological risk assessment of eight selected human pharmaceuticals in Japan. , 2007, Environmental sciences : an international journal of environmental physiology and toxicology.

[92]  Stuart J Khan,et al.  Modelling of pharmaceutical residues in Australian sewage by quantities of use and fugacity calculations. , 2004, Chemosphere.

[93]  Sac-fry Stages,et al.  OECD GUIDELINE FOR TESTING OF CHEMICALS , 2002 .

[94]  S. Jørgensen,et al.  Algal Toxicity of Antibacterial Agents Applied in Danish Fish Farming , 1999, Archives of environmental contamination and toxicology.