The identification of individuals at high risk for large bowel cancer. An overview

Attempts to identify individuals with increased susceptibility to colon cancer before clinical manifestations of disease, have recently been made. Early stages of abnormal growth of colonic epithelial cells, and related factors that may contribute to the development of colonic neoplasia have been shown. Based on the identification of early findings, programs to prevent the evolution of malignancy in individuals at increased risk are under consideration at the present time.

[1]  F. Mitelman,et al.  The specificity of the chromosomal abnormalities in human colonic polyps. A cytogenetic study of multiple polyps in a case of Gardner's syndrome. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.

[2]  P. Nilsson,et al.  Chromosome banding pattern in human colonic polyps. , 2009, Hereditas.

[3]  R. Condon,et al.  Surgical and medical measures in prevention of large bowel cancer , 1977, Cancer.

[4]  M. Lipkin,et al.  Defective recognitive immunity in family aggregates of colon carcinoma. , 1977, The Journal of clinical investigation.

[5]  L. Kopelovich,et al.  Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten murine sarcoma virus , 1977, Cell.

[6]  M. Lipkin,et al.  Fecal bile acids and neutral sterols in patients with familial polyposis , 1976, Cancer.

[7]  V. Allfrey,et al.  Characteristic complements of nuclear nonhistone proteins in colonic epithelial tumors. , 1976, Cancer research.

[8]  M. Baliś,et al.  Biochemical changes in preneoplastic rodent intestines. , 1976, Cancer research.

[9]  K. Hasegawa,et al.  Cellular kinetics and histological changes in experimental cancer of the uterine cervix. , 1976, Cancer research.

[10]  M. Lipkin.  Biology of large bowel cancer. Present status and research frontiers , 1975, Cancer.

[11]  B. Drasar,et al.  Proceedings: Colon cancer and bacterial metabolism in familial polyposis. , 1975, Gut.

[12]  G. Schrauzer,et al.  Effects of selenium and of arsenic on the genesis of spontaneous mammary tumors in inbred C3H mice. , 1974, Annals of clinical and laboratory science.

[13]  D. Paul,et al.  Changes in growth control and growth requirements associated with neoplastic transformation in vitro. , 1974, Journal of the National Cancer Institute.

[14]  T. Wilkins,et al.  Two patterns of neutral steroid conversion in the feces of normal North Americans. , 1974, Cancer research.

[15]  M. J. Hill,et al.  Bacteria and the etiology of colonic cancer , 1974, Cancer.

[16]  E. Deschner.  Experimentally induced cancer of the colon , 1974, Cancer.

[17]  V. Gilbertsen.  Proctosigmoidoscopy and polypectomy in reducing the incidence of rectal cancer , 1974, Cancer.

[18]  E. Lovett,et al.  Familial Factors in the Etiology of Carcinoma of the Large Bowel , 1974, Proceedings of the Royal Society of Medicine.

[19]  M. Baliś,et al.  Distribution and regulation of deoxythymidine kinase activity in differentiating cells of mammalian intestines. , 1973, Cancer research.

[20]  M. Lipkin,et al.  Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. , 1973, Cancer research.

[21]  G. Eastwood,et al.  Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis. , 1973, Gastroenterology.

[22]  W. dodds,et al.  Peutz-Jeghers syndrome and gastrointestinal malignancy. , 1972, The American journal of roentgenology, radium therapy, and nuclear medicine.

[23]  H. Temin,et al.  Stimulation by serum of multiplication of stationary chicken cells , 1971, Journal of cellular physiology.

[24]  P. Correa,et al.  Cancer of the colon and rectum and adenomatous polyps: A review of epidemiologic findings , 1971, Cancer.

[25]  M. Lipkin,et al.  Nucleic acid metabolism in proliferating and differentiating colonic cells of man and in neoplastic lesions of the colon. , 1971, Cancer research.

[26]  V. McKusick,et al.  Gardner's syndrome: Formal genetics and statistical analysis of a large Canadian kindred , 1970 .

[27]  H. Bussey,et al.  Predisposing causes of intestinal cancer. , 1970, Current problems in surgery.

[28]  M. Eder,et al.  Morphologische und autoradiographische Untersuchung der Darmschleimhautveränderungen nach einmaliger Injektion von 1,2-Dimethylhydrazin , 1969 .

[29]  B. Drasar,et al.  Bacteria and the aetiology of cancer of the large bowel. , 1969, Gut.

[30]  E. Pierce.  Some genetic aspects of familial multiple polyposis of the colon in a kindred of 1,422 members , 1968, Diseases of the colon and rectum.

[31]  J. Thompson.  Hereditary Factors in Carcinoma , 1967 .

[32]  H. Lynch,et al.  Heredity and adenocarcinoma of the colon. , 1967, Gastroenterology.

[33]  H. Enterline,et al.  Chromosome constitution of adenoma and adenocarcinoma of the colon , 1967, Cancer.

[34]  E. Wynder,et al.  Environmental factors of cancer of the colon and rectum , 1967, Cancer.

[35]  G. Wilbanks,et al.  DNA content of cervical intraepithelial neoplasia studied by two-wavelength Feulgen cytophotometry. , 1967, American journal of obstetrics and gynecology.

[36]  M. Lipkin,et al.  IN VITRO STUDY OF HUMAN RECTAL EPITHELIAL CELLS. I. ATYPICAL ZONE OF H3 THYMIDINE INCORPORATION IN MUCOSA OF MULTIPLE POLYPOSIS. , 1963, The Journal of clinical investigation.

[37]  E. Gardner.  Follow-up study of a family group exhibiting dominant inheritance for a syndrome including intestinal polyps, osteomas, fibromas and epidermal cysts. , 1962, American journal of human genetics.

[38]  V. McKusick.  Genetic factors in intestinal polyposis. , 1962, JAMA.

[39]  E. S. Murphy,et al.  Familial polyposis of the colon and gastric carcinoma. Concurrent conditions in a 16-year-old boy. , 1962, JAMA.

[40]  C. P. Leblond,et al.  Cell proliferation and migration as revealed by radioautography after injection of thymidine-H3 into male rats and mice. , 1960, The American journal of anatomy.

[41]  J. Despres,et al.  Malignant tumors of the central nervous system associated with familial polyposis of the colon , 1959 .

[42]  R. Richards,et al.  Solitary polyps of the colon and rectum: a study of inherited tendency. , 1956, The American surgeon.

[43]  Reed Te,et al.  A genetic study of multiple polyposis of the colon with an appendix deriving a method of estimating relative fitness. , 1955 .

[44]  M. Oldfield.  The association of familial polyposis of the colon with multiple sebaceous cysts , 1954, The British journal of surgery.

[45]  J. Halsted,et al.  Involvement of the stomach in familial polyposis of the gastro-intestinal tract; report of a family. , 1950, Gastroenterology.

[46]  V. McKusick,et al.  Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. , 1949, The New England journal of medicine.

[47]  T. Shows,et al.  Genetics of colon carcinogenesis in mice treated with 1,2-dimethylhydrazine. , 1977, Cancer research.

[48]  A. Watne,et al.  Fecal steroids and bacterial flora in patients with polyposis coli. , 1976, American journal of surgery.

[49]  J. Exon,et al.  Relationship of dietary selenium concentration; chemical cancer induction; and tissue concentration of selenium in rats. , 1973, Clinical toxicology.

[50]  M. Lipkin,et al.  Study of human rectal epithelial cells in vitro. III. RNA, protein, and DNA synthesis in polyps and adjacent mucosa. , 1970, Journal of the National Cancer Institute.

[51]  P. Springer,et al.  [The early stages of the 1,2-dimethylhydrazine-induced carcinoma of the small and large intestine of rats]. , 1970, Zeitschrift fur Krebsforschung.

[52]  S. Winawer,et al.  Cell proliferation kinetics in the gastrointestinal tract of man. IV. Cell renewal in the intestinalized gastric mucosa. , 1969, Journal of the National Cancer Institute.

[53]  E. Andrews,et al.  Selenium-responsive diseases of animals in New Zealand. , 1968, New Zealand veterinary journal.

[54]  J. A. Bargen,et al.  Multiple carcinomas of the large intestine: a review of the literature and a study of 261 cases. , 1958, Gastroenterology.

[55]  E. Gardner,et al.  Occasional discrete polyps of the colon and rectum showing an inherited tendency in a kindred , 1955, Cancer.