Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging.
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Alnawaz Rehemtulla | Daniel A Hamstra | Brian D Ross | B. Ross | A. Rehemtulla | D. Hamstra | M. Bhojani | L. Griffin | B. Laxman | Bharathi Laxman | Mahaveer S Bhojani | Laura B Griffin
[1] Francesca Storici,et al. Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence , 2002, Molecular and Cellular Biology.
[2] Peng Huang,et al. The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo , 2002, Cell.
[3] S. Kern,et al. High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter. , 2003, Carcinogenesis.
[4] Vasilis Ntziachristos,et al. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. , 2003, Medical physics.
[5] Wafik S El-Deiry,et al. Bioluminescent Molecular Imaging of Endogenous and Exogenous p53-Mediated Transcription In Vitro and In Vivo Using an HCT116 Human Colon Carcinoma Xenograft Model , 2003, Cancer biology & therapy.
[6] R. Weinberg,et al. Tumor spectrum analysis in p53-mutant mice , 1994, Current Biology.
[7] Xin Lu,et al. Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes? , 1993, Cell.
[8] A. Gudkov,et al. Different impact of p53 and p21 on the radiation response of mouse tissues , 2000, Oncogene.
[9] G. Stark,et al. Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo , 1997, The EMBO journal.
[10] M. Oren,et al. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. , 1995, Nucleic acids research.
[11] Uri Alon,et al. Dynamics of the p53-Mdm2 feedback loop in individual cells , 2004, Nature Genetics.
[12] John Jeremy Rice,et al. A plausible model for the digital response of p53 to DNA damage. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[13] I. Barash,et al. Real‐time imaging of β‐lactoglobulin‐targeted luciferase activity in the mammary glands of transgenic mice , 2002, Molecular reproduction and development.
[14] U Alon,et al. Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[15] M. Dewhirst,et al. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. , 2005, International journal of radiation oncology, biology, physics.
[16] B. Vikram,et al. Phase III randomized trial of amifostine as a radioprotector in head and neck cancer. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[17] G. M. Leclerc,et al. Development of a destabilized firefly luciferase enzyme for measurement of gene expression. , 2000, BioTechniques.
[18] S S Gambhir,et al. Noninvasive optical imaging of firefly luciferase reporter gene expression in skeletal muscles of living mice. , 2001, Molecular therapy : the journal of the American Society of Gene Therapy.
[19] C. Mcginn,et al. The mechanism of action of radiosensitization of conventional chemotherapeutic agents. , 2003, Seminars in radiation oncology.
[20] A. Gudkov,et al. The role of p53 in determining sensitivity to radiotherapy , 2003, Nature Reviews Cancer.
[21] E. Wright,et al. Tissue‐specific p53 responses to ionizing radiation and their genetic modification: the key to tissue‐specific tumour susceptibility? , 2003, The Journal of pathology.
[22] Shengyun Fang,et al. Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53* , 2000, The Journal of Biological Chemistry.
[23] M. Hollstein,et al. Clinical implications of the p53 tumor-suppressor gene. , 1993, The New England journal of medicine.
[24] G. Wahl,et al. A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation , 2005, Cell cycle.
[25] A. Levine,et al. Surfing the p53 network , 2000, Nature.
[26] P. Gruss,et al. Transgenic mouse model for studying the transcriptional activity of the p53 protein: age‐ and tissue‐dependent changes in radiation‐induced activation during embryogenesis , 1997, The EMBO journal.
[27] Galit Lahav,et al. The Strength of Indecisiveness: Oscillatory Behavior for Better Cell Fate Determination , 2004, Science's STKE.
[28] N. Monk. Oscillatory Expression of Hes1, p53, and NF-κB Driven by Transcriptional Time Delays , 2003, Current Biology.
[29] L. Milas,et al. Radioprotection of mouse jejunum by WR-2721 and WR-1065: effects on DNA strand-break induction and rejoining. , 1988, Radiation research.
[30] David Piwnica-Worms,et al. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice , 2005, Nature Methods.
[31] W. El-Deiry,et al. Tissue-specific induction of p53 targets in vivo. , 2002, Cancer research.
[32] K. Kinzler,et al. Definition of a consensus binding site for p53 , 1992, Nature Genetics.
[33] A. Gudkov,et al. Prospective therapeutic applications of p53 inhibitors. , 2005, Biochemical and biophysical research communications.
[34] M. E. Perry. Mdm2 in the response to radiation. , 2004, Molecular cancer research : MCR.
[35] T. Soussi,et al. p53 mutation heterogeneity in cancer. , 2005, Biochemical and biophysical research communications.
[36] R. Leahy,et al. Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging , 2005, Physics in medicine and biology.
[37] T. Lawrence,et al. Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells. , 1990, International journal of radiation oncology, biology, physics.
[38] D. Schaffer,et al. Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells , 2004, Biotechnology and bioengineering.
[39] L. Núñez,et al. Episodic gonadotropin-releasing hormone gene expression revealed by dynamic monitoring of luciferase reporter activity in single, living neurons. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[40] A. Wyllie,et al. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. , 1994, Oncogene.
[41] J. Levine,et al. Surfing the p53 network , 2000, Nature.
[42] M. E. Perry,et al. The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress , 2000, Molecular and Cellular Biology.
[43] U. Lopes,et al. p53-dependent Induction of Apoptosis by Proteasome Inhibitors* , 1997, The Journal of Biological Chemistry.
[44] Andrea Ciliberto,et al. Steady States and Oscillations in the p53/Mdm2 Network , 2005, Cell cycle.
[45] J. Goldblum,et al. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice , 2004, Oncogene.
[46] M. Oren,et al. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. , 1993, Oncogene.