Caffeine Model of Panic

Much attention has been focused on the neurobiology of panic disorder. According to the DSM-III-R classification of panic disorders, panic attacks are given central importance in the genesis and maintenance of secondary complications such as agoraphobia, anticipatory anxiety, and, in a subgroup of patients, major depressive symptomatology. Given this perspective, it is important to understand the pathophysiology and biological correlates of “spontaneous” or “unprovoked” panic attacks.