SREBPs: the crossroads of physiological and pathological lipid homeostasis

[1]  Peter J Espenshade,et al.  Regulation of sterol synthesis in eukaryotes. , 2007, Annual review of genetics.

[2]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[3]  X. Deng,et al.  Expression of the Rat Sterol Regulatory Element-binding Protein-1c Gene in Response to Insulin Is Mediated by Increased Transactivating Capacity of Specificity Protein 1 (Sp1)* , 2007, Journal of Biological Chemistry.

[4]  J. Goldstein,et al.  Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins , 2007, Proceedings of the National Academy of Sciences.

[5]  Joseph L. Goldstein,et al.  Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig , 2007, Proceedings of the National Academy of Sciences.

[6]  J. Ericsson,et al.  SREBP in signal transduction: cholesterol metabolism and beyond. , 2007, Current opinion in cell biology.

[7]  F. Foufelle,et al.  SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective , 2007, Hormone Research in Paediatrics.

[8]  M. Laville,et al.  Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs. , 2006, The Biochemical journal.

[9]  Han-Woong Lee,et al.  Chromatin Remodeling Complex Interacts with ADD1/SREBP1c To Mediate Insulin-Dependent Regulation of Gene Expression , 2006, Molecular and Cellular Biology.

[10]  J. Ericsson,et al.  Phosphorylation and Ubiquitination of the Transcription Factor Sterol Regulatory Element-binding Protein-1 in Response to DNA Binding* , 2006, Journal of Biological Chemistry.

[11]  D. Accili,et al.  Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. , 2006, The Journal of clinical investigation.

[12]  John S. Satterlee,et al.  An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis , 2006, Nature.

[13]  C. Newgard,et al.  Obesity-related derangements in metabolic regulation. , 2006, Annual review of biochemistry.

[14]  J. Shyy,et al.  Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. , 2006, American journal of physiology. Cell physiology.

[15]  C. Kahn,et al.  Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. , 2006, Cell metabolism.

[16]  K. Yamamoto,et al.  A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. , 2006, Genes & development.

[17]  K. Heidenreich,et al.  FoxO1 Regulates Multiple Metabolic Pathways in the Liver , 2006, Journal of Biological Chemistry.

[18]  P. Espenshade SREBPs: sterol-regulated transcription factors. , 2006, Journal of cell science.

[19]  R. Raghow,et al.  Insulin Dynamically Regulates Calmodulin Gene Expression by Sequential O-Glycosylation and Phosphorylation of Sp1 and Its Subcellular Compartmentalization in Liver Cells* , 2006, Journal of Biological Chemistry.

[20]  C. Kahn,et al.  Critical nodes in signalling pathways: insights into insulin action , 2006, Nature Reviews Molecular Cell Biology.

[21]  Joseph L. Goldstein,et al.  Protein Sensors for Membrane Sterols , 2006, Cell.

[22]  D. Jump,et al.  Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways Published, JLR Papers in Press, October 12, 2005. , 2006, Journal of Lipid Research.

[23]  C. Kahn,et al.  Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. , 2005, Hepatology research : the official journal of the Japan Society of Hepatology.

[24]  S. Olshansky Projecting the future of U.S. health and longevity. , 2005, Health affairs.

[25]  B. Song,et al.  Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. , 2005, Molecular cell.

[26]  R. Hammer,et al.  Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. , 2005, The Journal of clinical investigation.

[27]  J. Ericsson,et al.  Hyperphosphorylation regulates the activity of SREBP1 during mitosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Zhaoping Li,et al.  Health ramifications of the obesity epidemic. , 2005, The Surgical clinics of North America.

[29]  J. Goldstein,et al.  Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦ , 2005, Journal of Biological Chemistry.

[30]  X. Deng,et al.  Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP. , 2005, Biochemical and biophysical research communications.

[31]  J. Harper,et al.  Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). , 2005, Cell metabolism.

[32]  B. Song,et al.  Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. , 2005, Cell metabolism.

[33]  T. Osborne,et al.  Activation Domains from Both Monomers Contribute to Transcriptional Stimulation by Sterol Regulatory Element-binding Protein Dimers* , 2005, Journal of Biological Chemistry.

[34]  Christoph Handschin,et al.  Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP , 2005, Cell.

[35]  F. Foufelle,et al.  Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[36]  X. Deng,et al.  Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression. , 2004, Endocrinology.

[37]  F. Foufelle,et al.  SREBP transcription factors: master regulators of lipid homeostasis. , 2004, Biochimie.

[38]  Joon-No Lee,et al.  Proteolytic Activation of Sterol Regulatory Element-binding Protein Induced by Cellular Stress through Depletion of Insig-1* , 2004, Journal of Biological Chemistry.

[39]  T. Osborne,et al.  Selective Coactivator Interactions in Gene Activation by SREBP-1a and -1c , 2004, Molecular and Cellular Biology.

[40]  Guoxun Chen,et al.  Trace: Tennessee Research and Creative Exchange Nutrition Publications and Other Works Nutrition Central Role for Liver X Receptor in Insulin-mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Recommended Citation , 2022 .

[41]  Anne-Bénédicte Boullay,et al.  Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment. , 2004, Biochemical pharmacology.

[42]  G. Colditz,et al.  The epidemic of obesity. , 2004, The Journal of clinical endocrinology and metabolism.

[43]  Jinping Li,et al.  Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Deckelbaum,et al.  Ceramide Synthesis Correlates with the Posttranscriptional Regulation of the Sterol-Regulatory Element-Binding Protein , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[45]  R. Hammer,et al.  Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. , 2004, The Journal of clinical investigation.

[46]  C. Fielding,et al.  Role of p160 Coactivator Complex in the Activation of Liver X Receptor , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[47]  J. Goldstein,et al.  Membrane Topology of Human Insig-1, a Protein Regulator of Lipid Synthesis* , 2004, Journal of Biological Chemistry.

[48]  E. Tarling,et al.  Transcriptional regulation of human SREBP-1c (sterol-regulatory-element-binding protein-1c): a key regulator of lipogenesis. , 2004, Biochemical Society transactions.

[49]  Jay D. Horton,et al.  Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[50]  T. Noda,et al.  PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. , 2003, The Journal of clinical investigation.

[51]  J. Goldstein,et al.  Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[52]  J. Goldstein,et al.  Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Goldstein,et al.  Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[54]  B. A. Janowski The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[55]  F. Foufelle,et al.  New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. , 2002, The Biochemical journal.

[56]  R. Aebersold,et al.  Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER , 2002, Cell.

[57]  H. Shimano,et al.  Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice* , 2002, The Journal of Biological Chemistry.

[58]  D. Jump,et al.  Dietary polyunsaturated fatty acids and regulation of gene transcription , 2002, Current opinion in lipidology.

[59]  Rebecca A. Johnson,et al.  Unsaturated Fatty Acid-mediated Decreases in Sterol Regulatory Element-mediated Gene Transcription Are Linked to Cellular Sphingolipid Metabolism* , 2002, The Journal of Biological Chemistry.

[60]  X. Deng,et al.  Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. , 2002, Biochemical and biophysical research communications.

[61]  Hitoshi Shimano,et al.  Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter , 2001, Molecular and Cellular Biology.

[62]  J. Goldstein,et al.  Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells* , 2001, The Journal of Biological Chemistry.

[63]  Jean-Marc A. Lobaccaro,et al.  Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .

[64]  D. Müller-Wieland,et al.  MAP Kinases Erk1/2 Phosphorylate Sterol Regulatory Element-binding Protein (SREBP)-1a at Serine 117 in Vitro * , 2000, The Journal of Biological Chemistry.

[65]  T. Osborne,et al.  Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action* , 2000, The Journal of Biological Chemistry.

[66]  H. Shimano,et al.  Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene* , 2000, The Journal of Biological Chemistry.

[67]  J. Goldstein,et al.  Molecular Characterization of Human Acetyl-CoA Synthetase, an Enzyme Regulated by Sterol Regulatory Element-binding Proteins* , 2000, The Journal of Biological Chemistry.

[68]  R. Hammer,et al.  Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. , 2000, Molecular cell.

[69]  Jay D. Horton,et al.  Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus* , 1999, The Journal of Biological Chemistry.

[70]  R. Hammer,et al.  Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.

[71]  I. Shimomura,et al.  Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[72]  R. Brines Trends in Endocrinology and Metabolism 1998 , 1998, Trends in Endocrinology & Metabolism.

[73]  T. Doering,et al.  Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. , 1997, Journal of cell science.

[74]  M. Brown,et al.  Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[75]  N. Spinner,et al.  Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. , 1997, Genomics.

[76]  J. Goldstein,et al.  The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.

[77]  I. Shimomura,et al.  Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. , 1997, The Journal of clinical investigation.

[78]  M. Brown,et al.  Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[79]  J. Hsu,et al.  The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes , 1991, Molecular and cellular biology.

[80]  Joseph L Goldstein,et al.  Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. , 2006, Cell metabolism.

[81]  X. Deng,et al.  Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. , 2005, The Biochemical journal.

[82]  J. Goldstein,et al.  Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. , 2003, Molecular cell.

[83]  I. Shimomura,et al.  Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. , 2000, Genes & development.

[84]  B. Spiegelman,et al.  Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. , 1998, The Journal of clinical investigation.