SREBPs: the crossroads of physiological and pathological lipid homeostasis
暂无分享,去创建一个
X. Deng | E. Park | R. Raghow | M. Elam | C. Yellaturu
[1] Peter J Espenshade,et al. Regulation of sterol synthesis in eukaryotes. , 2007, Annual review of genetics.
[2] B. Spiegelman,et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.
[3] X. Deng,et al. Expression of the Rat Sterol Regulatory Element-binding Protein-1c Gene in Response to Insulin Is Mediated by Increased Transactivating Capacity of Specificity Protein 1 (Sp1)* , 2007, Journal of Biological Chemistry.
[4] J. Goldstein,et al. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins , 2007, Proceedings of the National Academy of Sciences.
[5] Joseph L. Goldstein,et al. Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig , 2007, Proceedings of the National Academy of Sciences.
[6] J. Ericsson,et al. SREBP in signal transduction: cholesterol metabolism and beyond. , 2007, Current opinion in cell biology.
[7] F. Foufelle,et al. SREBP-1c Transcription Factor and Lipid Homeostasis: Clinical Perspective , 2007, Hormone Research in Paediatrics.
[8] M. Laville,et al. Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs. , 2006, The Biochemical journal.
[9] Han-Woong Lee,et al. Chromatin Remodeling Complex Interacts with ADD1/SREBP1c To Mediate Insulin-Dependent Regulation of Gene Expression , 2006, Molecular and Cellular Biology.
[10] J. Ericsson,et al. Phosphorylation and Ubiquitination of the Transcription Factor Sterol Regulatory Element-binding Protein-1 in Response to DNA Binding* , 2006, Journal of Biological Chemistry.
[11] D. Accili,et al. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. , 2006, The Journal of clinical investigation.
[12] John S. Satterlee,et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis , 2006, Nature.
[13] C. Newgard,et al. Obesity-related derangements in metabolic regulation. , 2006, Annual review of biochemistry.
[14] J. Shyy,et al. Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. , 2006, American journal of physiology. Cell physiology.
[15] C. Kahn,et al. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. , 2006, Cell metabolism.
[16] K. Yamamoto,et al. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. , 2006, Genes & development.
[17] K. Heidenreich,et al. FoxO1 Regulates Multiple Metabolic Pathways in the Liver , 2006, Journal of Biological Chemistry.
[18] P. Espenshade. SREBPs: sterol-regulated transcription factors. , 2006, Journal of cell science.
[19] R. Raghow,et al. Insulin Dynamically Regulates Calmodulin Gene Expression by Sequential O-Glycosylation and Phosphorylation of Sp1 and Its Subcellular Compartmentalization in Liver Cells* , 2006, Journal of Biological Chemistry.
[20] C. Kahn,et al. Critical nodes in signalling pathways: insights into insulin action , 2006, Nature Reviews Molecular Cell Biology.
[21] Joseph L. Goldstein,et al. Protein Sensors for Membrane Sterols , 2006, Cell.
[22] D. Jump,et al. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways Published, JLR Papers in Press, October 12, 2005. , 2006, Journal of Lipid Research.
[23] C. Kahn,et al. Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome. , 2005, Hepatology research : the official journal of the Japan Society of Hepatology.
[24] S. Olshansky. Projecting the future of U.S. health and longevity. , 2005, Health affairs.
[25] B. Song,et al. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. , 2005, Molecular cell.
[26] R. Hammer,et al. Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. , 2005, The Journal of clinical investigation.
[27] J. Ericsson,et al. Hyperphosphorylation regulates the activity of SREBP1 during mitosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[28] Zhaoping Li,et al. Health ramifications of the obesity epidemic. , 2005, The Surgical clinics of North America.
[29] J. Goldstein,et al. Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦ , 2005, Journal of Biological Chemistry.
[30] X. Deng,et al. Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP. , 2005, Biochemical and biophysical research communications.
[31] J. Harper,et al. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). , 2005, Cell metabolism.
[32] B. Song,et al. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. , 2005, Cell metabolism.
[33] T. Osborne,et al. Activation Domains from Both Monomers Contribute to Transcriptional Stimulation by Sterol Regulatory Element-binding Protein Dimers* , 2005, Journal of Biological Chemistry.
[34] Christoph Handschin,et al. Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP , 2005, Cell.
[35] F. Foufelle,et al. Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[36] X. Deng,et al. Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression. , 2004, Endocrinology.
[37] F. Foufelle,et al. SREBP transcription factors: master regulators of lipid homeostasis. , 2004, Biochimie.
[38] Joon-No Lee,et al. Proteolytic Activation of Sterol Regulatory Element-binding Protein Induced by Cellular Stress through Depletion of Insig-1* , 2004, Journal of Biological Chemistry.
[39] T. Osborne,et al. Selective Coactivator Interactions in Gene Activation by SREBP-1a and -1c , 2004, Molecular and Cellular Biology.
[40] Guoxun Chen,et al. Trace: Tennessee Research and Creative Exchange Nutrition Publications and Other Works Nutrition Central Role for Liver X Receptor in Insulin-mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver. Recommended Citation , 2022 .
[41] Anne-Bénédicte Boullay,et al. Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment. , 2004, Biochemical pharmacology.
[42] G. Colditz,et al. The epidemic of obesity. , 2004, The Journal of clinical endocrinology and metabolism.
[43] Jinping Li,et al. Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[44] R. Deckelbaum,et al. Ceramide Synthesis Correlates with the Posttranscriptional Regulation of the Sterol-Regulatory Element-Binding Protein , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[45] R. Hammer,et al. Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. , 2004, The Journal of clinical investigation.
[46] C. Fielding,et al. Role of p160 Coactivator Complex in the Activation of Liver X Receptor , 2004, Arteriosclerosis, thrombosis, and vascular biology.
[47] J. Goldstein,et al. Membrane Topology of Human Insig-1, a Protein Regulator of Lipid Synthesis* , 2004, Journal of Biological Chemistry.
[48] E. Tarling,et al. Transcriptional regulation of human SREBP-1c (sterol-regulatory-element-binding protein-1c): a key regulator of lipogenesis. , 2004, Biochemical Society transactions.
[49] Jay D. Horton,et al. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[50] T. Noda,et al. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. , 2003, The Journal of clinical investigation.
[51] J. Goldstein,et al. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[52] J. Goldstein,et al. Liver-specific mRNA for Insig-2 down-regulated by insulin: Implications for fatty acid synthesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[53] J. Goldstein,et al. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[54] B. A. Janowski. The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[55] F. Foufelle,et al. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. , 2002, The Biochemical journal.
[56] R. Aebersold,et al. Crucial Step in Cholesterol Homeostasis Sterols Promote Binding of SCAP to INSIG-1, a Membrane Protein that Facilitates Retention of SREBPs in ER , 2002, Cell.
[57] H. Shimano,et al. Absence of Sterol Regulatory Element-binding Protein-1 (SREBP-1) Ameliorates Fatty Livers but Not Obesity or Insulin Resistance inLep ob /Lep ob Mice* , 2002, The Journal of Biological Chemistry.
[58] D. Jump,et al. Dietary polyunsaturated fatty acids and regulation of gene transcription , 2002, Current opinion in lipidology.
[59] Rebecca A. Johnson,et al. Unsaturated Fatty Acid-mediated Decreases in Sterol Regulatory Element-mediated Gene Transcription Are Linked to Cellular Sphingolipid Metabolism* , 2002, The Journal of Biological Chemistry.
[60] X. Deng,et al. Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. , 2002, Biochemical and biophysical research communications.
[61] Hitoshi Shimano,et al. Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter , 2001, Molecular and Cellular Biology.
[62] J. Goldstein,et al. Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells* , 2001, The Journal of Biological Chemistry.
[63] Jean-Marc A. Lobaccaro,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .
[64] D. Müller-Wieland,et al. MAP Kinases Erk1/2 Phosphorylate Sterol Regulatory Element-binding Protein (SREBP)-1a at Serine 117 in Vitro * , 2000, The Journal of Biological Chemistry.
[65] T. Osborne,et al. Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action* , 2000, The Journal of Biological Chemistry.
[66] H. Shimano,et al. Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene* , 2000, The Journal of Biological Chemistry.
[67] J. Goldstein,et al. Molecular Characterization of Human Acetyl-CoA Synthetase, an Enzyme Regulated by Sterol Regulatory Element-binding Proteins* , 2000, The Journal of Biological Chemistry.
[68] R. Hammer,et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. , 2000, Molecular cell.
[69] Jay D. Horton,et al. Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus* , 1999, The Journal of Biological Chemistry.
[70] R. Hammer,et al. Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.
[71] I. Shimomura,et al. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[72] R. Brines. Trends in Endocrinology and Metabolism 1998 , 1998, Trends in Endocrinology & Metabolism.
[73] T. Doering,et al. Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. , 1997, Journal of cell science.
[74] M. Brown,et al. Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[75] N. Spinner,et al. Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene. , 1997, Genomics.
[76] J. Goldstein,et al. The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.
[77] I. Shimomura,et al. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. , 1997, The Journal of clinical investigation.
[78] M. Brown,et al. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[79] J. Hsu,et al. The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes , 1991, Molecular and cellular biology.
[80] Joseph L Goldstein,et al. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. , 2006, Cell metabolism.
[81] X. Deng,et al. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. , 2005, The Biochemical journal.
[82] J. Goldstein,et al. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. , 2003, Molecular cell.
[83] I. Shimomura,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. , 2000, Genes & development.
[84] B. Spiegelman,et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. , 1998, The Journal of clinical investigation.