Overcoming tumor microenvironment obstacles: Current approaches for boosting nanodrug delivery.

[1]  W. Zhang,et al.  AIPH-Encapsulated Thermo-Sensitive Liposomes for Synergistic Microwave Ablation and Oxygen-independent Dynamic Therapy. , 2023, Advanced healthcare materials.

[2]  Yang Luo,et al.  Intelligent Dual-Lock Deoxyribonucleic Acid Automatons Boosting Precise Tumor Imaging. , 2023, ACS applied materials & interfaces.

[3]  R. Pei,et al.  Cancer-associated fibroblast-targeted nanodrugs reshape colorectal tumor microenvironments to suppress tumor proliferation, metastasis and improve drug penetration. , 2022, Journal of materials chemistry. B.

[4]  Zhao Ma,et al.  Transformable nanoparticles to bypass biological barriers in cancer treatment , 2022, Nanoscale advances.

[5]  E. Nice,et al.  Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies , 2022, Journal of Hematology & Oncology.

[6]  Kinam Park,et al.  Challenging the fundamental conjectures in nanoparticle drug delivery for chemotherapy treatment of solid cancers. , 2022, Advanced drug delivery reviews.

[7]  Xuanrong Sun,et al.  Legumain/pH dual-responsive lytic peptide–paclitaxel conjugate for synergistic cancer therapy , 2022, Drug delivery.

[8]  E. Gazit,et al.  Ultrasound-Responsive Peptide Nanogels to Balance Conflicting Requirements for Deep Tumor Penetration and Prolonged Blood Circulation. , 2022, ACS nano.

[9]  Wei Huang,et al.  Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines , 2022, Advanced science.

[10]  S. Mitragotri,et al.  Strategies to improve the EPR effect: A mechanistic perspective and clinical translation. , 2022, Journal of controlled release : official journal of the Controlled Release Society.

[11]  Sheng Lin,et al.  Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer , 2022, Drug delivery.

[12]  G. Wang,et al.  Transferrin Protein Corona-Modified CuGd Core-Shell Nanoplatform for Tumor-Targeting Photothermal and Chemodynamic Synergistic Therapies. , 2022, ACS applied materials & interfaces.

[13]  S. Horrigan,et al.  Combination of Histone Deacetylase Inhibitor Panobinostat (LBH589) with β-Catenin Inhibitor Tegavivint (BC2059) Exerts Significant Anti-Myeloma Activity Both In Vitro and In Vivo , 2022, Cancers.

[14]  Yueqing Gu,et al.  A cascade synergetic strategy induced by photothermal effect based on platelet exosome nanoparticles for tumor therapy. , 2022, Biomaterials.

[15]  Yihui Deng,et al.  PEGylated nanoemulsions containing 1,2-distearoyl-sn-glycero-3-phosphoglycerol induced weakened accelerated blood clearance phenomenon , 2021, Drug Delivery and Translational Research.

[16]  Wei Wang,et al.  A nano-catalyst promoting endogenous NO production enhance chemotherapy efficacy by vascular normalization , 2022, Materials Chemistry Frontiers.

[17]  Wing‐Leung Wong,et al.  Review of Functionalized Nanomaterials for Photothermal Therapy of Cancers , 2021, ACS Applied Nano Materials.

[18]  D. Berry,et al.  Neoadjuvant T-DM1/pertuzumab and paclitaxel/trastuzumab/pertuzumab for HER2+ breast cancer in the adaptively randomized I-SPY2 trial , 2021, Nature Communications.

[19]  Xuebin Ma,et al.  Effect of Elasticity of Silica Capsules on Cellular Uptake. , 2021, Langmuir : the ACS journal of surfaces and colloids.

[20]  Xuan Yi,et al.  Emerging strategies based on nanomaterials for ionizing radiation-optimized drug treatment of cancer. , 2021, Nanoscale.

[21]  Yiye Li,et al.  Penetration Cascade of Size Switchable Nanosystem in Desmoplastic Stroma for Improved Pancreatic Cancer Therapy. , 2021, ACS nano.

[22]  Ruibing Wang,et al.  Polyamine-Responsive Morphological Transformation of a Supramolecular Peptide for Specific Drug Accumulation and Retention in Cancer Cells. , 2021, Small.

[23]  Xuesi Chen,et al.  Prodrug-Based Versatile Nanomedicine with Simultaneous Physical and Physiological Tumor Penetration for Enhanced Cancer Chemo-Immunotherapy. , 2021, Nano letters.

[24]  T. Ishida,et al.  Evidence for Delivery of Abraxane via a Denatured-Albumin Transport System. , 2021, ACS applied materials & interfaces.

[25]  J. Tuszynski,et al.  The Uniqueness of Albumin as a Carrier in Nanodrug Delivery. , 2021, Molecular pharmaceutics.

[26]  Assaf Zinger,et al.  Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles , 2021, ACS nano.

[27]  Yaping Li,et al.  Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy. , 2020, Biomaterials.

[28]  K. Lam,et al.  Tumor Receptor-Mediated In Vivo Modulation of the Morphology, Phototherapeutic Properties, and Pharmacokinetics of Smart Nanomaterials. , 2020, ACS nano.

[29]  Liang Yan,et al.  Progress, challenges, and future of nanomedicine , 2020 .

[30]  Xiaodi Zhang,et al.  Enhancement of Pancreatic Cancer Therapy Efficacy by Type-1 Matrix Metalloproteinase-Functionalized Nanoparticles for the Selective Delivery of Gemcitabine and Erlotinib , 2020, Drug design, development and therapy.

[31]  P. Lan,et al.  Engineered exosome for NIR-triggered drug delivery and superior synergistic chemo-phototherapy in a glioma model , 2020 .

[32]  S. Wilhelm,et al.  Nanoparticle Toxicology. , 2020, Annual review of pharmacology and toxicology.

[33]  Yan-Hua Su,et al.  MicroRNA-101 inhibits cadmium-induced angiogenesis by targeting cyclooxygenase-2 in primary human umbilical vein endothelial cells. , 2020, Biochemical pharmacology.

[34]  Weiling Fu,et al.  Spatiotemporally Controllable MicroRNA Imaging in Living Cells via NIR-activated Nanoprobe. , 2020, ACS applied materials & interfaces.

[35]  Yong Gan,et al.  MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy , 2020, Advanced science.

[36]  W. Zhong,et al.  Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling. , 2020, ACS nano.

[37]  Challenging paradigms in tumour drug delivery , 2020, Nature Materials.

[38]  S. Nie,et al.  Active transcytosis and new opportunities for cancer nanomedicine , 2020, Nature Materials.

[39]  Hanchun Yao,et al.  Mild Acid Responsive "Nanoenzyme Capsule" Remodeling of Tumor Microenvironment to Increase Tumor Penetration. , 2020, ACS applied materials & interfaces.

[40]  T. Higashi,et al.  Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain. , 2020, ACS applied bio materials.

[41]  Man Li,et al.  Targeting cancer-associated fibroblasts by dual-responsive lipid-albumin nanoparticles to enhance drug perfusion for pancreatic tumor therapy. , 2020, Journal of controlled release : official journal of the Controlled Release Society.

[42]  P. Liang,et al.  Chemotherapeutic Nanoparticle-Based Liposomes Enhance the Efficiency of Mild Microwave Ablation in Hepatocellular Carcinoma Therapy , 2020, Frontiers in Pharmacology.

[43]  J. Moodera,et al.  One compound with two distinct topological states , 2020, Nature Materials.

[44]  D. Zhao,et al.  Size and charge dual-transformable mesoporous nanoassemblies for enhanced drug delivery and tumor penetration† , 2020, Chemical science.

[45]  Yuancheng Li,et al.  Probing and Enhancing Ligand-Mediated Active Targeting of Tumors Using Sub-5 nm Ultrafine Iron Oxide Nanoparticles , 2020, Theranostics.

[46]  Hao Wang,et al.  Photothermal-Promoted Morphology Transformation in Vivo Monitored by Photoacoustic Imaging. , 2020, Nano letters.

[47]  S. Wilhelm,et al.  The entry of nanoparticles into solid tumours , 2020, Nature Materials.

[48]  Shibo Wang,et al.  Remodeling extracellular matrix based on functional covalent organic framework to enhance tumor photodynamic therapy. , 2020, Biomaterials.

[49]  Yury E. Glazyrin,et al.  Aptamer-Conjugated Superparamagnetic Ferroarabinogalactan Nanoparticles for Targeted Magnetodynamic Therapy of Cancer , 2020, Cancers.

[50]  Stefanie Wedepohl,et al.  Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model , 2020, Theranostics.

[51]  Yaping Li,et al.  Long Circulation Red‐Blood‐Cell‐Mimetic Nanoparticles with Peptide‐Enhanced Tumor Penetration for Simultaneously Inhibiting Growth and Lung Metastasis of Breast Cancer , 2016, Advanced Functional Materials.

[52]  Yu Zhang,et al.  Engineered nanomedicines with enhanced tumor penetration , 2019 .

[53]  A. Chiang,et al.  Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies , 2019, Nature Nanotechnology.

[54]  Jin-Zhi Du,et al.  Intratumor Performance and Therapeutic Efficacy of PAMAM Dendrimers Carried by Clustered Nanoparticles. , 2019, Nano letters.

[55]  Arun Prasath,et al.  Nanoparticles' interactions with vasculature in diseases. , 2019, Chemical Society reviews.

[56]  Peng Xu,et al.  Size effect of mesoporous organosilica nanoparticles on tumor penetration and accumulation. , 2019, Biomaterials science.

[57]  Z. Qian,et al.  Aggregable nanoparticles-enabled chemotherapy and autophagy inhibition combined with anti-PD-L1 antibody for improved glioma treatment. , 2019, Nano letters.

[58]  Zhuang Liu,et al.  Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy , 2019, Science Advances.

[59]  Xing-Jie Liang,et al.  Thermo-responsive triple-function nanotransporter for efficient chemo-photothermal therapy of multidrug-resistant bacterial infection , 2019, Nature Communications.

[60]  Tingting Meng,et al.  Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells , 2019, Theranostics.

[61]  T. Dvir,et al.  Collagenase Nanoparticles Enhance the Penetration of Drugs Into Pancreatic Tumors. , 2019, ACS nano.

[62]  Hélder A Santos,et al.  Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy , 2019, Nature Communications.

[63]  Jing Wang,et al.  Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles , 2019, Nature Communications.

[64]  Huajian Gao,et al.  Role of Nanoparticle Mechanical Properties in Cancer Drug Delivery. , 2019, ACS nano.

[65]  Zhihua Gan,et al.  Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy , 2019, Nature Nanotechnology.

[66]  Jeffrey W. Clark,et al.  Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer: A Phase 2 Clinical Trial. , 2019, JAMA oncology.

[67]  Yong Wang,et al.  Shape Effect of Nanoparticles on Tumor Penetration in Monolayers Versus Spheroids. , 2019, Molecular pharmaceutics.

[68]  Jun Xu,et al.  Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer , 2019, Advanced Functional Materials.

[69]  Yapei Zhang,et al.  Near-Infrared-Light Induced Nanoparticles with Enhanced Tumor Tissue Penetration and Intelligent Drug Release , 2019, Acta biomaterialia.

[70]  Jie Tian,et al.  Microwave Responsive Nanoplatform via P-Selectin Mediated Drug Delivery for Treatment of Hepatocellular Carcinoma with Distant Metastasis. , 2019, Nano letters.

[71]  Samir Mitragotri,et al.  Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers. , 2019, Advanced drug delivery reviews.

[72]  M. I. Setyawati,et al.  Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness , 2019, Nature Nanotechnology.

[73]  Jiajun Fu,et al.  Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release , 2019, Journal of Materials Science.

[74]  Z. Meng,et al.  Cancer-Associated Fibroblasts in Pancreatic Cancer: Should They Be Deleted or Reeducated? , 2018, Integrative cancer therapies.

[75]  X. Yang,et al.  Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem , 2018, Nature Communications.

[76]  Di Zhang,et al.  Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis. , 2018, Biomaterials.

[77]  Ding Ding,et al.  Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors. , 2018, ACS nano.

[78]  Ling Li,et al.  Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier , 2018, Nano Research.

[79]  Jinzhao Huang,et al.  Synergizing Upconversion Nanophotosensitizers with Hyperbaric Oxygen to Remodel the Extracellular Matrix for Enhanced Photodynamic Cancer Therapy. , 2018, ACS applied materials & interfaces.

[80]  Xinghua Shi,et al.  Targeting Endothelial Cell Junctions with Negatively Charged Gold Nanoparticles , 2018 .

[81]  Huan Meng,et al.  Use of nano engineered approaches to overcome the stromal barrier in pancreatic cancer. , 2018, Advanced drug delivery reviews.

[82]  Triantafyllos Stylianopoulos,et al.  Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. , 2018, Trends in cancer.

[83]  Bo Zhang,et al.  Cyclopamine treatment disrupts extracellular matrix and alleviates solid stress to improve nanomedicine delivery for pancreatic cancer , 2018, Journal of drug targeting.

[84]  Jianhua Zhang,et al.  Modulating the rigidity of nanoparticles for tumor penetration. , 2018, Chemical communications.

[85]  A. Middelberg,et al.  Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting. , 2018, ACS nano.

[86]  Chen Jiang,et al.  Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy , 2018, Advanced science.

[87]  Gang Zheng,et al.  Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics. , 2018, Biomaterials.

[88]  Youyong Yuan,et al.  Ultrafast charge-conversional nanocarrier for tumor-acidity-activated targeted drug elivery. , 2018, Biomaterials science.

[89]  P. Decuzzi,et al.  Modulating Phagocytic Cell Sequestration by Tailoring Nanoconstruct Softness. , 2018, ACS nano.

[90]  Ronnie H. Fang,et al.  Nanoparticle Functionalization with Platelet Membrane Enables Multifactored Biological Targeting and Detection of Atherosclerosis. , 2017, ACS nano.

[91]  Dongdong Li,et al.  Photoswitchable Ultrafast Transactivator of Transcription (TAT) Targeting Effect for Nanocarrier‐Based On‐Demand Drug Delivery , 2018 .

[92]  Dong Hwee Kim,et al.  Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy , 2018 .

[93]  M. Moses,et al.  Nanoparticle elasticity directs tumor uptake , 2018, Nature Communications.

[94]  Qixian Chen,et al.  Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness. , 2017, ACS applied materials & interfaces.

[95]  Yu Sakurai,et al.  Nano‐sized drug carriers: Extravasation, intratumoral distribution, and their modeling , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[96]  Pengcheng Zhang,et al.  Regulating cancer associated fibroblasts with losartan-loaded injectable peptide hydrogel to potentiate chemotherapy in inhibiting growth and lung metastasis of triple negative breast cancer. , 2017, Biomaterials.

[97]  Ick Chan Kwon,et al.  Extracellular matrix remodeling in vivo for enhancing tumor‐targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[98]  C. Moonen,et al.  Pharmacological and physical vessel modulation strategies to improve EPR-mediated drug targeting to tumors. , 2017, Advanced drug delivery reviews.

[99]  T. Ji,et al.  Designing Liposomes To Suppress Extracellular Matrix Expression To Enhance Drug Penetration and Pancreatic Tumor Therapy. , 2017, ACS nano.

[100]  K. Cai,et al.  Design of nanocarriers based on complex biological barriers in vivo for tumor therapy , 2017 .

[101]  Yaping Li,et al.  Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors. , 2017, Nano letters.

[102]  Xian‐Zheng Zhang,et al.  Stimuli-Responsive "Cluster Bomb" for Programmed Tumor Therapy. , 2017, ACS nano.

[103]  Yifat Brill-Karniely,et al.  Rigidity of polymer micelles affects interactions with tumor cells , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[104]  Bruno Larrivée,et al.  Tumor angiogenesis and vascular normalization: alternative therapeutic targets , 2017, Angiogenesis.

[105]  Jianjun Cheng,et al.  Sequentially Responsive Shell‐Stacked Nanoparticles for Deep Penetration into Solid Tumors , 2017, Advanced materials.

[106]  David R. Myers,et al.  Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions , 2017, Nature Communications.

[107]  Ting-Wei Yu,et al.  Hierarchically Targeted and Penetrated Delivery of Drugs to Tumors by Size‐Changeable Graphene Quantum Dot Nanoaircrafts for Photolytic Therapy , 2017 .

[108]  Miles A. Miller,et al.  Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts , 2017, Science Translational Medicine.

[109]  Leaf Huang,et al.  Quercetin Remodels the Tumor Microenvironment To Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles. , 2017, ACS nano.

[110]  Chor Yong Tay,et al.  Gold Nanoparticles Induced Endothelial Leakiness Depends on Particle Size and Endothelial Cell Origin. , 2017, ACS nano.

[111]  Youqing Shen,et al.  Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization , 2017, Advanced materials.

[112]  Mahdi Karimi,et al.  Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light. , 2017, Journal of the American Chemical Society.

[113]  Xiyi Chen,et al.  Controlled PEGylation Crowdedness for Polymeric Micelles To Pursue Ligand-Specified Privileges as Nucleic Acid Delivery Vehicles. , 2017, ACS applied materials & interfaces.

[114]  K. Bensalah,et al.  A Systematic Review and Meta-analysis Comparing the Effectiveness and Adverse Effects of Different Systemic Treatments for Non-clear Cell Renal Cell Carcinoma. , 2017, European urology.

[115]  D. Xing,et al.  Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy. , 2017, Biomaterials.

[116]  M. I. Setyawati,et al.  Mesoporous Silica Nanoparticles as an Antitumoral-Angiogenesis Strategy. , 2017, ACS applied materials & interfaces.

[117]  E. Ruoslahti Tumor penetrating peptides for improved drug delivery , 2017, Advanced drug delivery reviews.

[118]  K. Kogure,et al.  Tumor Microenvironment-Sensitive Liposomes Penetrate Tumor Tissue via Attenuated Interaction of the Extracellular Matrix and Tumor Cells and Accompanying Actin Depolymerization. , 2017, Biomacromolecules.

[119]  I. Correia,et al.  The effect of the shape of gold core-mesoporous silica shell nanoparticles on the cellular behavior and tumor spheroid penetration. , 2016, Journal of materials chemistry. B.

[120]  Ligeng Xu,et al.  Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy , 2016, Nature Communications.

[121]  S. Shen,et al.  Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer. , 2016, Biomaterials.

[122]  Huile Gao Shaping Tumor Microenvironment for Improving Nanoparticle Delivery. , 2016, Current drug metabolism.

[123]  Flavio Rizzolio,et al.  Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models. , 2016, Nanomedicine.

[124]  Haijun Yu,et al.  Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer. , 2016, ACS nano.

[125]  I. Park,et al.  Pazopanib versus sunitinib for the treatment of metastatic renal cell carcinoma patients with poor-risk features , 2016, Cancer Chemotherapy and Pharmacology.

[126]  Jun Wang,et al.  Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration. , 2016, ACS nano.

[127]  Shaoyi Jiang,et al.  Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response , 2016 .

[128]  M. Maskos,et al.  Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake. , 2016, Macromolecular bioscience.

[129]  Joseph W. Nichols,et al.  Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. , 2016, Nature nanotechnology.

[130]  E. Rankin,et al.  Hypoxia: Signaling the Metastatic Cascade. , 2016, Trends in cancer.

[131]  Quanyin Hu,et al.  ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging , 2016, Theranostics.

[132]  A. J. Tavares,et al.  Analysis of nanoparticle delivery to tumours , 2016 .

[133]  I. Tohnai,et al.  Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles , 2016, Scientific Reports.

[134]  Hao Cheng,et al.  Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy. , 2016, Nano letters.

[135]  Liangzhu Feng,et al.  Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy. , 2016, Nano letters.

[136]  Jun Wang,et al.  Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy , 2016, Proceedings of the National Academy of Sciences.

[137]  Yuliang Zhao,et al.  Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer‐Associated Fibroblast Activation , 2015, Angewandte Chemie.

[138]  K. Ghaghada,et al.  Crossing the barrier: treatment of brain tumors using nanochain particles. , 2016, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[139]  Yuan Yuan,et al.  Preferential tumor accumulation and desirable interstitial penetration of poly(lactic-co-glycolic acid) nanoparticles with dual coating of chitosan oligosaccharide and polyethylene glycol-poly(D,L-lactic acid). , 2016, Acta biomaterialia.

[140]  Shuai Shao,et al.  Doxorubicin encapsulated in stealth liposomes conferred with light-triggered drug release. , 2016, Biomaterials.

[141]  Qian Liu,et al.  Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[142]  Leaf Huang,et al.  Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[143]  William Y. Kim,et al.  Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[144]  Xing Guo,et al.  Size Changeable Nanocarriers with Nuclear Targeting for Effectively Overcoming Multidrug Resistance in Cancer Therapy , 2015, Advanced materials.

[145]  Huile Gao,et al.  Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment , 2015, Oncotarget.

[146]  Ying Li,et al.  Shape effect in cellular uptake of PEGylated nanoparticles: comparison between sphere, rod, cube and disk. , 2015, Nanoscale.

[147]  S. Sreenivasan,et al.  Effect of Shape, Size, and Aspect Ratio on Nanoparticle Penetration and Distribution inside Solid Tissues Using 3D Spheroid Models , 2015, Advanced healthcare materials.

[148]  Min Feng,et al.  Nanocarriers with tunable surface properties to unblock bottlenecks in systemic drug and gene delivery. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[149]  Xing-jie Liang,et al.  A Peptide‐Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy , 2015, Advanced materials.

[150]  I. Tannock,et al.  The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[151]  Yijia Zhang,et al.  Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. , 2015, Biomaterials.

[152]  B. Groner,et al.  Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma. , 2015, Cancer research.

[153]  Gang Bao,et al.  Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment. , 2015, Nanoscale.

[154]  Jianbin Tang,et al.  The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment. , 2015, ACS nano.

[155]  R. Haag,et al.  Dendritic nanocarriers based on hyperbranched polymers. , 2015, Chemical Society reviews.

[156]  Huile Gao,et al.  Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. , 2015, Nanoscale.

[157]  J. Kopeček,et al.  Enhancing Accumulation and Penetration of HPMA Copolymer-Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer. , 2015, Journal of the American Chemical Society.

[158]  Siling Wang,et al.  pH‐ and NIR Light‐Responsive Micelles with Hyperthermia‐Triggered Tumor Penetration and Cytoplasm Drug Release to Reverse Doxorubicin Resistance in Breast Cancer , 2015 .

[159]  M. Ferrari,et al.  Mild Hyperthermia Enhances Transport of Liposomal Gemcitabine and Improves In Vivo Therapeutic Response , 2015, Advanced healthcare materials.

[160]  Jennifer S. Yu,et al.  Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling. , 2015, Cancer research.

[161]  Erkki Ruoslahti,et al.  Nanoparticles coated with the tumor-penetrating peptide iRGD reduce experimental breast cancer metastasis in the brain , 2015, Journal of Molecular Medicine.

[162]  J. Willmann,et al.  Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[163]  H. Kuh,et al.  Improving drug delivery to solid tumors: priming the tumor microenvironment. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[164]  Baoquan Ding,et al.  Tunable Rigidity of (Polymeric Core)–(Lipid Shell) Nanoparticles for Regulated Cellular Uptake , 2015, Advanced materials.

[165]  Qiang Zhang,et al.  A comprehensive study of iRGD-modified liposomes with improved chemotherapeutic efficacy on B16 melanoma , 2015, Drug delivery.

[166]  E. Puré,et al.  Nanoparticles Functionalized with Collagenase Exhibit Improved Tumor Accumulation in a Murine Xenograft Model , 2014, Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems.

[167]  Youqing Shen,et al.  Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs , 2014, Advanced materials.

[168]  R. Jain,et al.  Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. , 2014, Cancer cell.

[169]  Andrew L. Ferguson,et al.  Investigating the optimal size of anticancer nanomedicine , 2014, Proceedings of the National Academy of Sciences.

[170]  Felix Kratz,et al.  A clinical update of using albumin as a drug vehicle - a commentary. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[171]  G. Wahl,et al.  Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy , 2014, Cell.

[172]  Brandon S. Brown,et al.  Bromelain Surface Modification Increases the Diffusion of Silica Nanoparticles in the Tumor Extracellular Matrix , 2014, ACS nano.

[173]  Mark E. Davis,et al.  Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA , 2014, Proceedings of the National Academy of Sciences.

[174]  Triantafyllos Stylianopoulos,et al.  The role of mechanical forces in tumor growth and therapy. , 2014, Annual review of biomedical engineering.

[175]  Wayne Kreider,et al.  Passive cavitation detection during pulsed HIFU exposures of ex vivo tissues and in vivo mouse pancreatic tumors. , 2014, Ultrasound in medicine & biology.

[176]  Q. Ping,et al.  Sequential intra-intercellular nanoparticle delivery system for deep tumor penetration. , 2014, Angewandte Chemie.

[177]  J. Hinchion,et al.  Releasing pressure in tumors: what do we know so far and where do we go from here? A review. , 2014, Cancer research.

[178]  Xiaoyuan Chen,et al.  Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles , 2014, ACS nano.

[179]  Xin Cai,et al.  Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution , 2014, ACS nano.

[180]  P. Decuzzi,et al.  Heat-generating iron oxide nanocubes: subtle "destructurators" of the tumoral microenvironment. , 2014, ACS nano.

[181]  Samir Mitragotri,et al.  Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects. , 2014, Nano today.

[182]  S. Šelemetjev,et al.  Enhanced activation of matrix metalloproteinase-9 correlates with the degree of papillary thyroid carcinoma infiltration , 2014, Croatian medical journal.

[183]  Baran D. Sumer,et al.  A Broad Nanoparticle-Based Strategy for Tumor Imaging by Nonlinear Amplification of Microenvironment Signals , 2013, Nature materials.

[184]  Aniruddha Roy,et al.  Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[185]  K. Rice,et al.  PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[186]  Takahiro Nomoto,et al.  Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier. , 2013, ACS nano.

[187]  Quanyin Hu,et al.  The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells. , 2013, Biomaterials.

[188]  H. Taguchi,et al.  Biomolecular robotics for chemomechanically driven guest delivery fuelled by intracellular ATP. , 2013, Nature chemistry.

[189]  Xian Xu,et al.  Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine. , 2013, Molecular pharmaceutics.

[190]  M. Yokoyama,et al.  Polymeric micelles possessing polyethyleneglycol as outer shell and their unique behaviors in accelerated blood clearance phenomenon. , 2013, Biological & pharmaceutical bulletin.

[191]  Yaping Li,et al.  Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking. , 2013, Small.

[192]  Dai Fukumura,et al.  Vascular normalization as an emerging strategy to enhance cancer immunotherapy. , 2013, Cancer research.

[193]  Say Chye Joachim Loo,et al.  Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin , 2013, Nature Communications.

[194]  X. Liu,et al.  iRGD-coupled responsive fluorescent nanogel for targeted drug delivery. , 2013, Biomaterials.

[195]  Min Wu,et al.  The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems. , 2013, Journal of theoretical biology.

[196]  Hyung J. Kim,et al.  Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. , 2013, ACS nano.

[197]  Derek S. Chan,et al.  Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer , 2012, Gut.

[198]  Anne L. van de Ven,et al.  Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. , 2013, Nature nanotechnology.

[199]  James E Bear,et al.  PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. , 2012, Nano letters.

[200]  Erkki Ruoslahti,et al.  Transtumoral targeting enabled by a novel neuropilin-binding peptide , 2012, Oncogene.

[201]  Alexander A. Fingerle,et al.  The role of stroma in pancreatic cancer: diagnostic and therapeutic implications , 2012, Nature Reviews Gastroenterology &Hepatology.

[202]  Samir Mitragotri,et al.  Materials for Drug Delivery: Innovative Solutions to Address Complex Biological Hurdles , 2012, Advanced materials.

[203]  F. Kiessling,et al.  Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[204]  I. Elkin,et al.  Drug-loaded nanocarriers: passive targeting and crossing of biological barriers. , 2012, Current medicinal chemistry.

[205]  E. Rofstad,et al.  High Interstitial Fluid Pressure Is Associated with Tumor-Line Specific Vascular Abnormalities in Human Melanoma Xenografts , 2012, PloS one.

[206]  Y. Barenholz Doxil®--the first FDA-approved nano-drug: lessons learned. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[207]  A. Ray,et al.  Guided Delivery of Polymer Therapeutics Using Plasmonic Photothermal Therapy. , 2012, Nano today.

[208]  T. Golub,et al.  Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion , 2012, Nature.

[209]  Robert Langer,et al.  Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile , 2012, Science Translational Medicine.

[210]  R. Jain,et al.  Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner , 2012, Nature nanotechnology.

[211]  R. Langer,et al.  Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery , 2012, Journal of the American Chemical Society.

[212]  Y. Maitani,et al.  Collagenase-1 injection improved tumor distribution and gene expression of cationic lipoplex. , 2012, International journal of pharmaceutics.

[213]  Z. Werb,et al.  The extracellular matrix: A dynamic niche in cancer progression , 2012, The Journal of cell biology.

[214]  M. Uesaka,et al.  Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. , 2011, Nature nanotechnology.

[215]  Jin-Zhi Du,et al.  Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery. , 2011, Journal of the American Chemical Society.

[216]  S. Dangi‐Garimella,et al.  MT1-MMP Cooperates with KrasG12D to Promote Pancreatic Fibrosis through Increased TGF-β Signaling , 2011, Molecular Cancer Research.

[217]  Mary E Napier,et al.  More effective nanomedicines through particle design. , 2011, Small.

[218]  Lei Xu,et al.  Normalization of the vasculature for treatment of cancer and other diseases. , 2011, Physiological reviews.

[219]  Jesse V Jokerst,et al.  Nanoparticle PEGylation for imaging and therapy. , 2011, Nanomedicine.

[220]  Ronnie H. Fang,et al.  Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform , 2011, Proceedings of the National Academy of Sciences.

[221]  J. Au,et al.  Paclitaxel tumor-priming enhances siRNA delivery and transfection in 3-dimensional tumor cultures. , 2011, Molecular pharmaceutics.

[222]  Y. Anraku,et al.  Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues. , 2011, Chemical communications.

[223]  Jun Fang,et al.  The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. , 2011, Advanced drug delivery reviews.

[224]  R. Jain,et al.  Delivering nanomedicine to solid tumors , 2010, Nature Reviews Clinical Oncology.

[225]  P. Wust,et al.  Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme , 2010, Journal of Neuro-Oncology.

[226]  Dai Fukumura,et al.  A nanoparticle size series for in vivo fluorescence imaging. , 2010, Angewandte Chemie.

[227]  Gaurav Sahay,et al.  Endocytosis of nanomedicines. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[228]  Erkki Ruoslahti,et al.  Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs , 2010, Science.

[229]  Jin-Zhi Du,et al.  A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery. , 2010, Angewandte Chemie.

[230]  Ick Chan Kwon,et al.  The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[231]  A. Giannis,et al.  Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives. , 2010, Angewandte Chemie.

[232]  Z. Werb,et al.  Matrix Metalloproteinases: Regulators of the Tumor Microenvironment , 2010, Cell.

[233]  Dong Chen,et al.  The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. , 2010, Biomaterials.

[234]  Leaf Huang,et al.  Nanoparticles evading the reticuloendothelial system: role of the supported bilayer. , 2009, Biochimica et biophysica acta.

[235]  Warren C W Chan,et al.  Mediating tumor targeting efficiency of nanoparticles through design. , 2009, Nano letters.

[236]  Victor Frenkel,et al.  Pulsed high intensity focused ultrasound mediated nanoparticle delivery: mechanisms and efficacy in murine muscle. , 2009, Ultrasound in medicine & biology.

[237]  I. Pastan,et al.  Pulsed High-Intensity Focused Ultrasound Enhances Uptake of Radiolabeled Monoclonal Antibody to Human Epidermoid Tumor in Nude Mice , 2008, Journal of Nuclear Medicine.

[238]  J. Au,et al.  Tumor Priming Enhances Delivery and Efficacy of Nanomedicines , 2007, Journal of Pharmacology and Experimental Therapeutics.

[239]  Xinguo Jiang,et al.  Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[240]  Kazunori Kataoka,et al.  Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling , 2007, Proceedings of the National Academy of Sciences.

[241]  K. Ulbrich,et al.  Effect of radiotherapy and hyperthermia on the tumor accumulation of HPMA copolymer-based drug delivery systems. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[242]  H. Maeda,et al.  Exploiting the enhanced permeability and retention effect for tumor targeting. , 2006, Drug discovery today.

[243]  Wilson Mok,et al.  Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. , 2006, Cancer research.

[244]  Hong-Zhuan Chen,et al.  In vivo tumor targeting of tumor necrosis factor-alpha-loaded stealth nanoparticles: effect of MePEG molecular weight and particle size. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[245]  Michael Hawkins,et al.  Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[246]  L. Brannon-Peppas,et al.  Nanoparticle and targeted systems for cancer therapy. , 2004, Advanced drug delivery reviews.

[247]  Rakesh K. Jain,et al.  Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors , 2004, Cancer Research.

[248]  Crispin J. Miller,et al.  Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance , 2004, Molecular and Cellular Biology.

[249]  Rakesh K. Jain,et al.  Pathology: Cancer cells compress intratumour vessels , 2004, Nature.

[250]  Michel Vert,et al.  Biodistribution of Long-Circulating PEG-Grafted Nanocapsules in Mice: Effects of PEG Chain Length and Density , 2001, Pharmaceutical Research.

[251]  J. M. Harris,et al.  Effect of pegylation on pharmaceuticals , 2003, Nature Reviews Drug Discovery.

[252]  D. Hedley,et al.  Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. , 2001, Cancer research.

[253]  M. Wientjes,et al.  Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. , 2001, The Journal of pharmacology and experimental therapeutics.

[254]  R. Müller,et al.  'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. , 2000, Colloids and surfaces. B, Biointerfaces.

[255]  D. Longo,et al.  Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. , 1993, Cancer research.

[256]  Kazuo Maruyama,et al.  Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes , 1990, FEBS letters.

[257]  H. Maeda,et al.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.