Is albumin safe?

The Saline versus Albumin Fluid Evaluation (SAFE) Study, reported in this issue of the Journal, 1 heralds a new era in critical care marked by the large, simple, randomized trial popularized by cardiologists. In a study of fluid resuscitation involving nearly 7000 critically ill patients, the Australian and New Zealand Intensive Care Society Clinical Trials Group addressed one of the most fundamental and contentious issues in critical care. Questions about the merits and demerits of colloids as opposed to crystalloids in the resuscitation of seriously ill patients have smoldered for decades, sparked by a meta-analysis suggesting that albumin was associated with . . .

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