Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells.

[1]  F. Sutterwala,et al.  Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ , 2005, Nature Immunology.

[2]  Jack T. Lin,et al.  TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet1 , 2005, The Journal of Immunology.

[3]  M. Caligiuri,et al.  Differential expression of SHIP1 in CD56bright and CD56dim NK cells provides a molecular basis for distinct functional responses to monokine costimulation. , 2005, Blood.

[4]  Yusuke Nakamura,et al.  Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma , 2005, Human Genetics.

[5]  Yuka Kanno,et al.  Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4 , 2004, Immunological reviews.

[6]  Sarah K. Meadows,et al.  Unique phenotype of human uterine NK cells and their regulation by endogenous TGF‐β , 2004, Journal of leukocyte biology.

[7]  R. Schreiber,et al.  The immunobiology of cancer immunosurveillance and immunoediting. , 2004, Immunity.

[8]  I. McInnes,et al.  Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. , 2004, Current opinion in pharmacology.

[9]  Dong-Wan Kim,et al.  Elevated TGF-β1 Secretion and Down-Modulation of NKG2D Underlies Impaired NK Cytotoxicity in Cancer Patients1 , 2004, The Journal of Immunology.

[10]  P. Farnham,et al.  T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. , 2004, Immunity.

[11]  K. Schroder,et al.  Interferon- : an overview of signals, mechanisms and functions , 2004 .

[12]  N. Mukaida,et al.  The Essential Involvement of Cross-Talk between IFN-γ and TGF-β in the Skin Wound-Healing Process1 , 2004, The Journal of Immunology.

[13]  K. Miyazono,et al.  Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. , 2003, Molecular biology of the cell.

[14]  S. Szabo,et al.  Antigen-driven effector CD8 T cell function regulated by T-bet , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A. Yoshimura,et al.  Negative regulation of cytokine signaling influences inflammation. , 2003, Current opinion in immunology.

[16]  Hao Shen,et al.  Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin , 2003, Science.

[17]  K. Murphy,et al.  Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. , 2003, International immunology.

[18]  A. Atfi,et al.  The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 Phosphorylation* , 2003, Journal of Biological Chemistry.

[19]  G. Bouma,et al.  The immunological and genetic basis of inflammatory bowel disease , 2003, Nature Reviews Immunology.

[20]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[21]  L. Glimcher,et al.  T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[22]  R. Biassoni,et al.  Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[23]  G. Trinchieri,et al.  Interleukin-12 and the regulation of innate resistance and adaptive immunity , 2003, Nature Reviews Immunology.

[24]  N. Sarvetnick,et al.  Cytokines: promoters and dampeners of autoimmunity. , 2002, Current opinion in immunology.

[25]  R. Schreiber,et al.  Cancer immunoediting: from immunosurveillance to tumor escape , 2002, Nature Immunology.

[26]  D. Foster,et al.  IL-21 Up-Regulates the Expression of Genes Associated with Innate Immunity and Th1 Response1 , 2002, The Journal of Immunology.

[27]  Ying E. Zhang,et al.  TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses , 2002 .

[28]  L. Chodosh,et al.  Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction , 2002, Nature Immunology.

[29]  Anjana Rao,et al.  TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes , 2002, Nature Immunology.

[30]  Richard A. Flavell,et al.  Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation , 2002, The Journal of experimental medicine.

[31]  T. Ohteki.  Critical role for IL-15 in innate immunity. , 2002, Current molecular medicine.

[32]  S. Szabo,et al.  The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease , 2002, The Journal of experimental medicine.

[33]  M. Goumans,et al.  Transforming growth factor β signal transduction , 2002, Journal of leukocyte biology.

[34]  S. Szabo,et al.  Distinct Effects of T-bet in TH1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells , 2002, Science.

[35]  Michael Q. Zhang,et al.  Computational identification of promoters and first exons in the human genome , 2001, Nature Genetics.

[36]  X. Hua,et al.  Cell cycle controlling the silencing and functioning of mammalian activators , 2001, Current Biology.

[37]  P. Boccuni,et al.  Characterization of two novel cell lines, DERL-2 (CD56+/CD3+/TCRγδ+) and DERL-7 (CD56+/CD3−/TCRγδ−), derived from a single patient with CD56+ non-Hodgkin's lymphoma , 2001, Leukemia.

[38]  Andrew L. Kung,et al.  Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection , 2001, Science.

[39]  M. Caligiuri,et al.  Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset , 2001 .

[40]  R. Schreiber,et al.  IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity , 2001, Nature.

[41]  R. Weinberg,et al.  Ski/Sno and TGF-β signaling , 2001 .

[42]  J. Gutkind,et al.  Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. , 2000, Blood.

[43]  I. Julkunen,et al.  IFN-α and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells1 , 2000, The Journal of Immunology.

[44]  M. Kaplan,et al.  The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression1 , 2000, The Journal of Immunology.

[45]  C. Dinarello,et al.  Proinflammatory cytokines. , 2000, Chest.

[46]  Laurie H Glimcher,et al.  A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.

[47]  M. Caligiuri,et al.  Cutting Edge: IL-15 Costimulates the Generalized Shwartzman Reaction and Innate Immune IFN-γ Production In Vivo1 , 2000, The Journal of Immunology.

[48]  S. Akira,et al.  The role of IL-18 in innate immunity. , 2000, Current opinion in immunology.

[49]  J. Gray,et al.  Role of NK cells and TGF-beta in the regulation of T-cell-dependent antibody production in health and autoimmune disease. , 1999, Microbes and infection.

[50]  M. Antonelli,et al.  Sepsis and septic shock: pro-inflammatory or anti-inflammatory state? , 1999, Journal of chemotherapy.

[51]  S. Reed.  TGF-β in infections and infectious diseases , 1999 .

[52]  R. Döffinger,et al.  IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. , 1999, Current opinion in immunology.

[53]  M. Caligiuri,et al.  Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. , 1999, Journal of immunology.

[54]  J. Galon,et al.  TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs. , 1999, Journal of immunology.

[55]  A. Roberts,et al.  Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β , 1999, The EMBO journal.

[56]  G. Trinchieri,et al.  Downregulation of interleukin-12 (IL-12) responsiveness in human T cells by transforming growth factor-beta: relationship with IL-12 signaling. , 1999, Blood.

[57]  J. Massagué,et al.  Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway , 1999, Nature.

[58]  R. Derynck,et al.  Transcriptional Activators of TGF-β Responses: Smads , 1998, Cell.

[59]  T. Born,et al.  Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling* , 1998, The Journal of Biological Chemistry.

[60]  S. Akira,et al.  IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. , 1998, Journal of immunology.

[61]  R. Derynck,et al.  Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription , 1998, Nature.

[62]  S. Sriram,et al.  TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes. , 1998, Journal of immunology.

[63]  P. Burd,et al.  Interferon-gamma-dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA-containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus-transformed lymphoblastoid cells. , 1998, Blood.

[64]  Anita B. Roberts,et al.  REGULATION OF IMMUNE RESPONSES BY TGF-β* , 1998 .

[65]  M. Hirokawa,et al.  Generation of an inhibitory circuit involving CD8+ T cells, IL-2, and NK cell-derived TGF-beta: contrasting effects of anti-CD2 and anti-CD3. , 1998, Journal of immunology.

[66]  C. Dinarello,et al.  Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. , 1997, Chest.

[67]  M. Hirokawa,et al.  The immunoregulatory effects of NK cells: the role of TGF-beta and implications for autoimmunity. , 1997, Immunology today.

[68]  J. Massagué,et al.  Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 , 1997, Nature.

[69]  S. Sriram,et al.  TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. , 1997, Journal of immunology.

[70]  H. Jun,et al.  Molecular role of TGF-beta, secreted from a new type of CD4+ suppressor T cell, NY4.2, in the prevention of autoimmune IDDM in NOD mice. , 1997, Journal of autoimmunity.

[71]  M. Caligiuri,et al.  Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regulate the innate immune response. , 1997, Blood.

[72]  H. Yang,et al.  A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[73]  R. Bone,et al.  Immunologic Dissonance: A Continuing Evolution in Our Understanding of the Systemic Inflammatory Response Syndrome (SIRS) and the Multiple Organ Dysfunction Syndrome (MODS) , 1996, Annals of Internal Medicine.

[74]  R. Derynck,et al.  Receptor-associated Mad homologues synergize as effectors of the TGF-β response , 1996, Nature.

[75]  G. Trinchieri,et al.  The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells , 1996, The Journal of experimental medicine.

[76]  G. Trinchieri,et al.  Regulation of NK cell functions by TGF-beta 1. , 1995, Journal of immunology.

[77]  G. Trinchieri.  Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis. , 1995, Seminars in immunology.

[78]  Jeffrey L. Wrana,et al.  Mechanism of activation of the TGF-β receptor , 1994, Nature.

[79]  M. Gately,et al.  Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. , 1994, Journal of immunology.

[80]  J. Gong,et al.  Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. , 1994, Leukemia.

[81]  E. Unanue,et al.  Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[82]  H. Shepard,et al.  Inhibition of cytokine production by cyclosporin A and transforming growth factor beta , 1987, The Journal of experimental medicine.

[83]  M. Caligiuri,et al.  Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector. , 2005, Journal of immunological methods.

[84]  Antonio Lanzavecchia,et al.  Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes , 2003, Nature Immunology.

[85]  Jianfei Yang,et al.  T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells , 2002, Nature Immunology.

[86]  H. Moses,et al.  Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. , 2001, Molecular biology of the cell.

[87]  J. Massagué,et al.  Smad Transcriptional Corepressors in TGFβ Family Signaling , 2001 .

[88]  H. Okamura,et al.  Interleukin-18 regulates both Th1 and Th2 responses. , 2001, Annual review of immunology.

[89]  G P Nolan,et al.  High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. , 1998, Cancer research.

[90]  A. Billiau,et al.  The role of cytokines in various animal models of inflammation. , 1989, Lymphokine research.