Anti-basal ganglia antibodies in patients with atypical dystonia and tics

Anti-basal ganglia antibodies (ABGA) are associated with movement disorders in children, but have not been assessed in adult onset movement disorders. In a prospective assessment ABGA were positive in 65% of a group of 65 patients with atypical movement disorders, but were very rare in healthy adults and adults with idiopathic dystonia. An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders.

[1]  M. Edwards,et al.  Adult‐onset tic disorder, motor stereotypies, and behavioural disturbance associated with antibasal ganglia antibodies , 2004, Movement disorders : official journal of the Movement Disorder Society.

[2]  K. Bhatia,et al.  A dystonic syndrome associated with anti-basal ganglia antibodies , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[3]  S. Swedo,et al.  Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea , 2003, Nature Medicine.

[4]  S. Swedo,et al.  Post-streptococcal autoimmune disorders of the central nervous system. , 2003, Current opinion in neurology.

[5]  A. Lees,et al.  Tourette’s syndrome: a cross sectional study to examine the PANDAS hypothesis , 2003, Journal of neurology, neurosurgery, and psychiatry.

[6]  A J Lees,et al.  Anti–basal ganglia antibodies in acute and persistent Sydenham’s chorea , 2002, Neurology.

[7]  B. Peterson,et al.  Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders , 2001, Biological Psychiatry.

[8]  M. Garvey,et al.  Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. , 1998, The American journal of psychiatry.

[9]  Moore Dp.  Neuropsychiatric aspects of Sydenham's chorea : A comprehensive review , 1996 .

[10]  D. Moore.  Neuropsychiatric aspects of Sydenham's chorea: a comprehensive review. , 1996, The Journal of clinical psychiatry.