Design and performance of a transformer-coupled double resonant quadrature birdcage coil for localized proton and phosphorus spectroscopy in the human calf muscle at 7 T

One of the major advantages of high field magnets is the increased signal-to-noise and spectral resolution for in vivo localized spectroscopy. In muscle studies, for example, the combination of proton and heteronuclear spectroscopy allows quantification of lipid content, fiber orientation, and cellular metabolic status. For clinical utilization it is important that spectra can be acquired in relatively short acquisition times for patient comfort and minimizing the effects of motion. Radiofrequency coils should ideally be fixed tuned and have relatively small effects with loading. Here, the design process and performance of a transformer-coupled double-tuned quadrature proton/phosphorus birdcage coil is described. The resulting coil is highly load-independent in terms of tuning, and despite the intrinsic reduced proton sensitivity compared to a single-tuned coil, clinically useful proton and phosphorus spectra can be acquired in a total time of less than 30 min. © 2014 Wiley Periodicals, Inc. Concepts Magn Reson Part A 42A: 155–164, 2013.

[1]  A. Webb,et al.  In vivo determination of human breast fat composition by 1H magnetic resonance spectroscopy at 7 T , 2012, Magnetic resonance in medicine.

[2]  Cecilia Possanzini,et al.  31P MRSI and 1H MRS at 7 T: initial results in human breast cancer , 2011, NMR in biomedicine.

[3]  G H Glover,et al.  Three‐point dixon technique for true water/fat decomposition with B0 inhomogeneity correction , 1991, Magnetic resonance in medicine.

[4]  J. Fitzsimmons,et al.  Double resonant quadrature birdcage , 1993, Magnetic resonance in medicine.

[5]  A G Webb,et al.  In vivo 31P MRS detection of an alkaline inorganic phosphate pool with short T1 in human resting skeletal muscle , 2010, NMR in biomedicine.

[6]  J R Fitzsimmons,et al.  A comparison of double‐tuned surface coils , 1989, Magnetic resonance in medicine.

[7]  A. Sherry,et al.  Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla* , 2008, Journal of Lipid Research.

[8]  S Trattnig,et al.  Assessment of 31P relaxation times in the human calf muscle: A comparison between 3 T and 7 T in vivo , 2009, Magnetic resonance in medicine.

[9]  J R Fitzsimmons,et al.  A transformer‐coupled double‐resonant probe for NMR imaging and spectroscopy , 1987, Magnetic resonance in medicine.

[10]  Joël Mispelter,et al.  NMR Probeheads for Biophysical and Biomedical Experiments: Theoretical Principles and Practical Guidelines , 2006 .

[11]  K. Uğurbil,et al.  In vivo 31P magnetic resonance spectroscopy of human brain at 7 T: An initial experience , 2003, Magnetic resonance in medicine.

[12]  R. Kreis,et al.  Mapping fiber orientation in human muscle by proton MR spectroscopic imaging , 2003, Magnetic resonance in medicine.

[13]  Vasily L Yarnykh,et al.  Actual flip‐angle imaging in the pulsed steady state: A method for rapid three‐dimensional mapping of the transmitted radiofrequency field , 2007, Magnetic resonance in medicine.

[14]  Peter R Luijten,et al.  Quantitative 31P magnetic resonance spectroscopy of the human breast at 7 T , 2012, Magnetic resonance in medicine.

[15]  Jeroen van der Grond,et al.  Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington’s disease provides in vivo evidence for impaired energy metabolism , 2011, Journal of Neurology.

[16]  Gülin Öz,et al.  Regional neurochemical profiles in the human brain measured by 1H MRS at 7 T using local B1 shimming , 2012, NMR in biomedicine.

[17]  W. J. M. Kemp,et al.  Adiabatic multi‐echo 31P spectroscopic imaging (AMESING) at 7 T for the measurement of transverse relaxation times and regaining of sensitivity in tissues with short T2* values , 2013, NMR in biomedicine.

[18]  A. Sherry,et al.  1H MRS of intramyocellular lipids in soleus muscle at 7 T: Spectral simplification by using long echo times without water suppression , 2010, Magnetic resonance in medicine.

[19]  Andrew G. Webb,et al.  Use of tailored higher modes of a birdcage to design a simple double‐tuned proton/phosphorus coil for human calf muscle studies at 7 T , 2011 .

[20]  Wei Chen,et al.  Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Wei Chen,et al.  Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain , 2007, Magnetic Resonance in Medicine.

[22]  Thomas H. Mareci,et al.  Essential considerations for spectral localization using indirect gradient encoding of spatial information , 1991 .

[23]  Christopher M Collins,et al.  BirdcageBuilder: Design of Specified-Geometry Birdcage Coils with Desired Current Pattern and Resonant Frequency. , 2002, Concepts in magnetic resonance.

[24]  D. Woessner,et al.  Orientation of lipid strands in the extracellular compartment of muscle: Effect on quantitation of intramyocellular lipids , 2009, Magnetic resonance in medicine.

[25]  Paul A. Keifer,et al.  90° pulse width calibrations: how to read a pulse width array , 1999 .

[26]  Peter Boesiger,et al.  Cardiac SSFP imaging at 3 Tesla , 2004, Magnetic resonance in medicine.

[27]  K. Uğurbil,et al.  In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T , 2009, Magnetic resonance in medicine.

[28]  Xiao-Hong Zhu,et al.  In vivo 31P MRS of human brain at high/ultrahigh fields: a quantitative comparison of NMR detection sensitivity and spectral resolution between 4 T and 7 T. , 2006, Magnetic resonance imaging.

[29]  T. Scheenen,et al.  Role of high‐field MR in studies of localized prostate cancer , 2014, NMR in biomedicine.