White-matter hyperintensity and neuropsychological functions in dementia and healthy aging.

The relationship between quantitative measurements of brain white-matter hyperintensity (WMH), assessed by magnetic resonance imaging and neuropsychological functions, was explored in demented patients and healthy aged individuals with and without WMH in 12 brain regions. The prevalence of WMH was significantly higher in vascular dementia compared with Alzheimer's disease, especially in posterior periventricular regions. Results showed no difference in any neuropsychological measurement between healthy aged adults with and without WMH. The demented patients with WMH were more impaired in tests of visuoconstruction, attention, finger-motor speed, and latency of tactile identification of objects compared with patients without WMH. These impairments were related mainly to posterior periventricular WMH. There was no relationship between WMH and global cognitive functioning in the demented patients. The degree of WMH was related to age and blood pressure. The data suggest that specific regional WMH may result in specific neuropsychological impairments.

[1]  A. Luria.  Higher Cortical Functions in Man , 1980, Springer US.

[2]  A. Brun,et al.  A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study , 1986, Annals of neurology.

[3]  M. Modic,et al.  Magnetic resonance imaging in vascular dementia , 1987, Neurology.

[4]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[5]  P. Colletti,et al.  Quantitative magnetic resonance imaging and the severity of dementia in Alzheimer's disease. , 1988, The American journal of psychiatry.

[6]  K. Blennow,et al.  White‐matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors , 1991, Acta neurologica Scandinavica.

[7]  D. Wechsler.  A Standardized Memory Scale for Clinical Use , 1945 .

[8]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[9]  B. Drayer,et al.  Imaging of the aging brain. Part I. Normal findings. , 1988, Radiology.

[10]  G. Langolf,et al.  Effect of occupational exposure to elemental mercury on short term memory. , 1983, British journal of industrial medicine.

[11]  I. Agartz,et al.  The brain in healthy aged individuals: MR imaging. , 1990, Radiology.

[12]  B. Drayer,et al.  Imaging of the aging brain. Part II. Pathologic conditions. , 1988, Radiology.

[13]  B Horwitz,et al.  White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study. , 1990, Archives of neurology.

[14]  V. Haughton,et al.  Neuropsychological test findings in subjects with leukoaraiosis. , 1989, Archives of neurology.

[15]  C. Coffey,et al.  White matter hyperintensity on magnetic resonance imaging: clinical and neuroanatomic correlates in the depressed elderly. , 1989, The Journal of neuropsychiatry and clinical neurosciences.

[16]  R F Spetzler,et al.  Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. , 1986, Stroke.

[17]  B. Turetsky,et al.  Preservation of normal cognitive functioning in elderly subjects with extensive white-matter lesions of long duration. , 1990, Archives of General Psychiatry.

[18]  A. Kertesz,et al.  Cognition and white matter changes on magnetic resonance imaging in dementia. , 1990, Archives of neurology.

[19]  V. Hachinski,et al.  Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). , 1987, Archives of neurology.

[20]  R F Spetzler,et al.  Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. , 1986, Stroke.

[21]  R. Penn,et al.  Cortical biopsy results in Alzheimer's disease , 1987, Neurology.

[22]  A. Alavi,et al.  MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. , 1987, AJR. American journal of roentgenology.

[23]  Daniel B Hier,et al.  MRI in the elderly , 1990, Neurology.

[24]  E. Kaplan,et al.  The Boston naming test , 2001 .

[25]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[26]  David Wechsler,et al.  Wechsler Intelligence Scale for Children; manual. , 1949 .

[27]  J. Rowe,et al.  Human aging: usual and successful. , 1987, Science.

[28]  J. Cummings.  Subcortical Dementia Neuropsychology, Neuropsychiatry, and Pathophysiology , 1986, British Journal of Psychiatry.

[29]  K. Haaland,et al.  Clinical significance of MRI white matter lesions in the elderly , 1989, Neurology.

[30]  T. Schenkenberg,et al.  Line bisection and unilateral visual neglect in patients with neurologic impairment , 1980, Neurology.

[31]  M. Husain,et al.  Cerebral white matter disease in late-onset paranoid psychosis , 1990, Biological Psychiatry.

[32]  Richard F. Thompson,et al.  Foci of Increased T2 Signal Intensity in MR Images of Healthy Elderly Subjects , 1990, Journal of the American Geriatrics Society.

[33]  Scott T. Grafton,et al.  Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter. , 1991, Archives of neurology.

[34]  F. Buonanno,et al.  Comparison of magnetic resonance and roentgen ray computed tomography in dementia. , 1987, Archives of neurology.

[35]  C. Nemeroff,et al.  Leukoencephalopathy in patients diagnosed as major depressive , 1988, Biological Psychiatry.

[36]  W. Snow,et al.  The NINCDS‐ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease , 1988, Neurology.

[37]  James C. Young,et al.  Periventricular White Matter Changes and Dementia: Clinical, Neuropsychological, Radiological, and Pathological Correlation , 1988 .

[38]  P. Colletti,et al.  Magnetic resonance imaging and the severity of dementia in older adults. , 1990, Archives of general psychiatry.

[39]  B C Bowen,et al.  MR signal abnormalities in memory disorder and dementia. , 1990, AJNR. American journal of neuroradiology.

[40]  T. H. Newton,et al.  Foci of MRI signal (pseudo lesions) anterior to the frontal horns: histologic correlations of a normal finding. , 1986, AJR. American journal of roentgenology.

[41]  D. Leys,et al.  Periventricular and white matter magnetic resonance imaging hyperintensities do not differ between Alzheimer's disease and normal aging. , 1990, Archives of neurology.