Exercise and the treatment of diabetes and obesity.

[1]  M. Laakso,et al.  Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance , 2008, Cell.

[2]  N. Larsson,et al.  Is Energy Deficiency Good in Moderation? , 2007, Cell.

[3]  L. C. V. van Loon,et al.  Optimizing the therapeutic benefits of exercise in Type 2 diabetes. , 2007, Journal of applied physiology.

[4]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[5]  H. Wyatt,et al.  The role of physical activity in producing and maintaining weight loss , 2007, Nature Clinical Practice Endocrinology &Metabolism.

[6]  B. Goodpaster,et al.  Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity. , 2007, Journal of applied physiology.

[7]  B. Pedersen,et al.  Body mass index‐independent effect of fitness and physical activity for all‐cause mortality , 2007, Scandinavian journal of medicine & science in sports.

[8]  C. Mantzoros,et al.  Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. , 2007, The Journal of biological chemistry.

[9]  M. Laakso,et al.  Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. , 2007, The Journal of clinical endocrinology and metabolism.

[10]  A. Gastaldelli,et al.  Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training , 2007, Diabetologia.

[11]  A. Klip,et al.  Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM , 1996, Diabetologia.

[12]  T. Gustafsson,et al.  Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC‐1α mRNA , 2006 .

[13]  J. Zierath,et al.  Low‐intensity exercise increases skeletal muscle protein expression of PPARδ and UCP3 in type 2 diabetic patients , 2006, Diabetes/metabolism research and reviews.

[14]  E. Reiling,et al.  Mitochondrial diabetes and its lessons for common Type 2 diabetes. , 2006, Biochemical Society transactions.

[15]  D. O'Gorman,et al.  Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes , 2006, Diabetologia.

[16]  Simon C Watkins,et al.  Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women. , 2006, The Journal of clinical endocrinology and metabolism.

[17]  J. Zierath,et al.  AMP-activated protein kinase signaling in metabolic regulation. , 2006, The Journal of clinical investigation.

[18]  M. Laakso,et al.  Single Nucleotide Polymorphisms of PPARD in Combination With the Gly482Ser Substitution of PGC-1A and the Pro12Ala Substitution of PPARG2 Predict the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes , 2006, Diabetes.

[19]  P. Neufer,et al.  Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training. , 2006, Journal of applied physiology.

[20]  K. Ohkawara,et al.  Effects of obesity phenotype on fat metabolism in obese men during endurance exercise , 2006, International Journal of Obesity.

[21]  A. Bonen,et al.  Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle. , 2006, Journal of applied physiology.

[22]  A. Hamsten,et al.  Differential expression of peroxisomal proliferator activated receptors α and δ in skeletal muscle in response to changes in diet and exercise , 2006 .

[23]  M. Tarnopolsky,et al.  The FASEB Journal express article 10.1096/fj.04-3149fje. Published online June 28, 2005. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise , 2022 .

[24]  M. Wolzt,et al.  Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. , 2005, Atherosclerosis.

[25]  A. Russell,et al.  Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise , 2005, The Journal of physiology.

[26]  E. Olson,et al.  Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers , 2005, Molecular and Cellular Biology.

[27]  P. Neufer,et al.  Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. , 2005, Metabolism: clinical and experimental.

[28]  U. Ekelund,et al.  PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men. , 2005, Journal of applied physiology.

[29]  R. Sigal,et al.  Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes , 2005, Diabetologia.

[30]  A. Russell,et al.  Regulation of metabolic transcriptional co‐activators and transcription factors with acute exercise , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  C. Bouchard,et al.  Endurance training-induced changes in insulin sensitivity and gene expression. , 2005, American journal of physiology. Endocrinology and metabolism.

[32]  Christoph Handschin,et al.  Metabolic control through the PGC-1 family of transcription coactivators. , 2005, Cell metabolism.

[33]  E. V. Menshikova,et al.  Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. , 2005, American journal of physiology. Endocrinology and metabolism.

[34]  B. Lowell,et al.  Mitochondrial Dysfunction and Type 2 Diabetes , 2005, Science.

[35]  A. Garnier,et al.  The FASEB Journal • Research Communication Coordinated , 2022 .

[36]  P. Schjerling,et al.  The FASEB Journal express article 10.1096/fj.04-2084fje. Published online October 29, 2004. Are exercise-induced genes induced by exercise? , 2022 .

[37]  B. Goodpaster,et al.  Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. , 2005, Diabetes.

[38]  M. Febbraio,et al.  Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes. , 2004, Journal of molecular endocrinology.

[39]  B. Braun,et al.  Effects of insulin resistance on substrate utilization during exercise in overweight women. , 2004, Journal of applied physiology.

[40]  R. Evans,et al.  Regulation of Muscle Fiber Type and Running Endurance by PPARδ , 2004, PLoS biology.

[41]  J. Zierath,et al.  Sending the signal: molecular mechanisms regulating glucose uptake. , 2004, Medicine and science in sports and exercise.

[42]  Nancy F Butte,et al.  Chronicle of the Institute of Medicine physical activity recommendation: how a physical activity recommendation came to be among dietary recommendations. , 2004, The American journal of clinical nutrition.

[43]  D. Fields,et al.  Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise. , 2004, American journal of physiology. Endocrinology and metabolism.

[44]  K. Petersen,et al.  Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. , 2004, The New England journal of medicine.

[45]  K. Eriksson,et al.  Prevention of Type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise The 6-year Malmö feasibility study , 1991, Diabetologia.

[46]  H. Lithell,et al.  Physical training as treatment for Type 2 (non-insulin-dependent) diabetes in elderly men. A feasibility study over 2 years , 1987, Diabetologia.

[47]  S. O’Rahilly,et al.  Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level? , 2004, Metabolism: clinical and experimental.

[48]  W. Kraus,et al.  PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle , 2004 .

[49]  U. Ekelund,et al.  PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max. , 2003, Medicine and science in sports and exercise.

[50]  A. Russell,et al.  Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. , 2003, Diabetes.

[51]  E. Olson,et al.  Skeletal Muscle Reprogramming by Activation of Calcineurin Improves Insulin Action on Metabolic Pathways* , 2003, Journal of Biological Chemistry.

[52]  A. Rose,et al.  Exercise Increases Ca2+–Calmodulin‐Dependent Protein Kinase II Activity in Human Skeletal Muscle , 2003, The Journal of physiology.

[53]  R. Baron,et al.  Effect of endurance training on muscle fat metabolism during prolonged exercise: agreements and disagreements. , 2003, Nutrition.

[54]  B. Goodpaster,et al.  Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. , 2003, Diabetes.

[55]  K. Nair,et al.  Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. , 2003, Diabetes.

[56]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[57]  A. Butte,et al.  Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[58]  B. Ainsworth,et al.  Physical Activity Levels Among Overweight and Obese Adults in South Carolina , 2003, Southern medical journal.

[59]  Jiandie D. Lin,et al.  An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[60]  A. Rissanen,et al.  How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement , 2003, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[61]  J. Holloszy,et al.  Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[62]  B. Kemp,et al.  Exercise increases nuclear AMPK α2 in human skeletal muscle , 2003 .

[63]  Henriette Pilegaard,et al.  Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle , 2003, The Journal of physiology.

[64]  A. Krook,et al.  Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non‐insulin dependent) diabetes mellitus , 2003, Clinical physiology and functional imaging.

[65]  S. Schiaffino,et al.  Calcineurin signaling and neural control of skeletal muscle fiber type and size. , 2002, Trends in pharmacological sciences.

[66]  L. Nolte,et al.  Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1 , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[67]  G. Shulman,et al.  AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[68]  Jing He,et al.  Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. , 2002, Diabetes.

[69]  Jiandie D. Lin,et al.  Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres , 2002, Nature.

[70]  J. Zierath.  Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle. , 2002, Journal of applied physiology.

[71]  R. Wolfe,et al.  Effects of Obesity on Substrate Utilization during Exercise , 2002 .

[72]  G. Wadley,et al.  Exercise training increases lipid metabolism gene expression in human skeletal muscle. , 2002, American journal of physiology. Endocrinology and metabolism.

[73]  S. Gordon,et al.  Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy. , 2002, Journal of applied physiology.

[74]  R. Bassel-Duby,et al.  Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK , 2002, Science.

[75]  W. Saris,et al.  Effect of exercise training at different intensities on fat metabolism of obese men. , 2002, Journal of applied physiology.

[76]  G. Hunter,et al.  Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. , 2002, American journal of physiology. Endocrinology and metabolism.

[77]  O. Hamdy,et al.  Diet and exercise in type 2 diabetes mellitus. , 2001, Endocrinology and metabolism clinics of North America.

[78]  G. Shulman,et al.  Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. , 2001, American journal of physiology. Endocrinology and metabolism.

[79]  J. Hawley,et al.  Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats. , 2001, Journal of applied physiology.

[80]  Glen P. Kenny,et al.  Effects of Exercise on Glycemic Control and Body Mass in Type 2 Diabetes Mellitus: A Meta-analysis of Controlled Clinical Trials , 2001 .

[81]  R. Ross,et al.  Physical activity, total and regional obesity: dose-response considerations. , 2001, Medicine and science in sports and exercise.

[82]  T. Valle,et al.  Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. , 2001, The New England journal of medicine.

[83]  A. Tremblay,et al.  Elevated intramyocellular lipid concentration in obese subjects is not reduced after diet and exercise training. , 2001, American journal of physiology. Endocrinology and metabolism.

[84]  W. Saris,et al.  The effect of low-intensity exercise training on fat metabolism of obese women. , 2001, Obesity Research.

[85]  J. Zierath,et al.  Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport. , 2001, Journal of applied physiology.

[86]  J. Horowitz,et al.  Lipid metabolism during endurance exercise. , 2000, The American journal of clinical nutrition.

[87]  J. Horowitz,et al.  Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training. , 2000, American journal of physiology. Endocrinology and metabolism.

[88]  Robert Ross,et al.  Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men , 2000, Annals of Internal Medicine.

[89]  B. Wolffenbuttel,et al.  Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle. , 2000, American journal of physiology. Endocrinology and metabolism.

[90]  W. Winder,et al.  Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. , 2000, Journal of applied physiology.

[91]  Simon C Watkins,et al.  Intramuscular lipid content is increased in obesity and decreased by weight loss. , 2000, Metabolism: clinical and experimental.

[92]  E. Olson,et al.  Stimulation of Slow Skeletal Muscle Fiber Gene Expression by Calcineurin in Vivo * , 2000, The Journal of Biological Chemistry.

[93]  D. O'Gorman,et al.  Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle. , 2000, Journal of applied physiology.

[94]  J. Zierath,et al.  Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. , 2000, Diabetes.

[95]  J. Zierath,et al.  Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[96]  J. Kampert,et al.  Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. , 1999, JAMA.

[97]  P. Bárány,et al.  An educational programme for persistent life-style changes in patients with chronic renal disease. , 1999, EDTNA/ERCA journal.

[98]  Z Trajanoski,et al.  Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. , 1999, The New England journal of medicine.

[99]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[100]  T. Valle,et al.  Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland Study design and 1-year interim report on the feasibility of the lifestyle intervention programme , 1999, Diabetologia.

[101]  S. Racette,et al.  Effects of endurance exercise training on muscle glycogen accumulation in humans. , 1999, Journal of applied physiology.

[102]  R. Robertson,et al.  Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM. , 1999, Medicine and science in sports and exercise.

[103]  B. Zinman,et al.  Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. , 1998, Diabetes.

[104]  J. Hoekstra,et al.  Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients. , 1997, Clinical science.

[105]  J. Simoneau,et al.  Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. , 1997, Journal of applied physiology.

[106]  B. Howard,et al.  Effects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes Study , 1997, Diabetes Care.

[107]  D L Rothman,et al.  Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. , 1996, The New England journal of medicine.

[108]  M. Uusitupa.  Early lifestyle intervention in patients with non-insulin-dependent diabetes mellitus and impaired glucose tolerance. , 1996, Annals of medicine.

[109]  J. Zierath,et al.  Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients. , 1996, The American journal of physiology.

[110]  A. Ighoroje,et al.  Changes in blood pressure and serum cholesterol following exercise training in Nigerian hypertensive subjects. , 1996, Journal of human hypertension.

[111]  Simon C Watkins,et al.  The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. , 1996, The Journal of clinical investigation.

[112]  E. Richter,et al.  Exercise-induced increase in glucose transport, GLUT-4, and VAMP-2 in plasma membrane from human muscle. , 1996, The American journal of physiology.

[113]  G. Bolstad,et al.  Muscle fibre type and dimension in genetically obese and lean Zucker rats. , 1995, Acta physiologica Scandinavica.

[114]  F. Dela,et al.  Insulin-Stimulated Muscle Glucose Clearance in Patients With NIDDM: Effects of One-Legged Physical Training , 1995, Diabetes.

[115]  O. Pedersen,et al.  Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[116]  K. Patrick,et al.  Physical Activity and Public Health: A Recommendation From the Centers for Disease Control and Prevention and the American College of Sports Medicine , 1995 .

[117]  J. Zierath.  In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport. , 1995, Acta physiologica Scandinavica. Supplementum.

[118]  E. Coyle,et al.  Fat metabolism during low-intensity exercise in endurance-trained and untrained men. , 1994, The American journal of physiology.

[119]  J. Simoneau,et al.  Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. , 1994, The Journal of clinical investigation.

[120]  J. Després,et al.  Low‐intensity endurance exercise training, plasma lipoproteins and the risk of coronary heart disease , 1994, Journal of internal medicine.

[121]  J. Holloszy,et al.  Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle. , 1994, The Journal of biological chemistry.

[122]  R G Shulman,et al.  Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. , 1994, Journal of applied physiology.

[123]  E. Coyle,et al.  Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest , 1993 .

[124]  R. Wolfe,et al.  Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. , 1993, The American journal of physiology.

[125]  N. Secher,et al.  Effect of training on insulin-mediated glucose uptake in human muscle. , 1992, The American journal of physiology.

[126]  P. Neufer,et al.  Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men. , 1991, The American journal of physiology.

[127]  T. Ohkuwa,et al.  Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. , 1990, The American journal of physiology.

[128]  A. Klip,et al.  Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. , 1990, The Journal of biological chemistry.

[129]  R G Shulman,et al.  Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. , 1990, The New England journal of medicine.

[130]  G. Dalsky,et al.  Insulin action and secretion in endurance-trained and untrained humans. , 1987, Journal of applied physiology.

[131]  G. Dalsky,et al.  Muscle triglyceride utilization during exercise: effect of training. , 1986, Journal of applied physiology.

[132]  D. Jacobs,et al.  The effects of exercise and weight loss on plasma lipids in young obese men. , 1985, Metabolism: clinical and experimental.

[133]  E. Coyle,et al.  Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[134]  G. Dudley,et al.  Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[135]  E Jansson,et al.  FIBER TYPES AND METABOLIC POTENTIALS OF SKELETAL MUSCLES IN SEDENTARY MAN AND ENDURANCE RUNNERS * , 1977, Annals of the New York Academy of Sciences.

[136]  F. Booth,et al.  Biochemical adaptations to endurance exercise in muscle. , 1976, Annual review of physiology.

[137]  G Grimby,et al.  Muscle fiber composition in patients with traumatic cord lesion. , 1976, Scandinavian journal of rehabilitation medicine.