Are the personality characteristics of astronauts related to their professional effectiveness? In order to answer this question, effectiveness and personality data were collected from 65 NASA astronauts. Several findings emerged from these data. Five personality subscales were related to effectiveness in one form or another. They were: high Negative Expressivity and Negative Communion (subordinate and gullible), low Impatience and Irritability, low Openness (to new ideas and experiences), low Negative Instrumentality (egoism) and high Agreeableness. Examining the graphs of these relationships indicated that they were not linear. This examination indicated that high levels on these undesirable personality characteristics (e.g., Impatience/Irritability) were distributed across all levels of effectiveness. Low levels of the undesirable personality characteristics were found only among the most effective astronauts. We concluded that these other-directed personality qualities will assume increasing importance in long-term spaceflight, and consequently, should be the focus of greater attention in future astronaut selection and training.