Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials.

BACKGROUND Some intervention studies have suggested that dairy products may influence body weight, but the results remain controversial. OBJECTIVE We identified and quantified the effects of dairy consumption on body weight and fat mass from randomized controlled trials (RCTs). DESIGN We conducted a comprehensive search of PubMed and EMBASE databases (to April 2012) of English reports of RCTs regarding dairy consumption on body weight, body fat, or body weight and body fat in adults. The results across studies were pooled by using a random-effects meta-analysis. RESULTS Twenty-nine RCTs were included with a total of 2101 participants. Overall, consumption of dairy products did not result in a significant reduction in weight (-0.14 kg; 95% CI: -0.66, 0.38 kg; I² = 86.3%). In subgroup analysis, consumption of dairy products reduced body weight in the context of energy restriction or short-term intervention (<1 y) trials but had the opposite effect in ad libitum dietary interventions or long-term trials (≥1 y). Twenty-two RCTs that reported results on body fat showed a modest reduction in the dairy group (-0.45 kg; 95% CI: -0.79, -0.11 kg; I² = 70.9%), and further stratified analysis indicated significant beneficial effects of dairy intervention on body fat in energy-restricted or short-term trials but not in long-term or ad libitum studies. CONCLUSIONS This meta-analysis does not support the beneficial effect of increasing dairy consumption on body weight and fat loss in long-term studies or studies without energy restriction. However, dairy products may have modest benefits in facilitating weight loss in short-term or energy-restricted RCTs.

[1]  Karen R Fitzgerald Review of article: Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 by Katherine M. Flegal, PhD; Margaret D. Carroll, MSPH; Brian K. Kit, MD; Cynthia L. Ogden, PhD (JAMA 2012;307:491-7). , 2013, Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing.

[2]  Katherine M Flegal,et al.  Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. , 2012, JAMA.

[3]  Ahmad Esmaillzadeh,et al.  Effect of dairy consumption on weight and body composition in adults: a systematic review and meta-analysis of randomized controlled clinical trials , 2012, International Journal of Obesity.

[4]  T. Sanders,et al.  The contribution of breakfast cereals to the nutritional intake of the materially deprived UK population , 2012, European Journal of Clinical Nutrition.

[5]  J. German,et al.  Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial , 2011, Nutrition & metabolism.

[6]  J. Rosado,et al.  Intake of milk with added micronutrients increases the effectiveness of an energy-restricted diet to reduce body weight: a randomized controlled clinical trial in Mexican women. , 2011, Journal of the American Dietetic Association.

[7]  M. Van Loan,et al.  Dairy Foods in a Moderate Energy Restricted Diet Do Not Enhance Central Fat, Weight, and Intra-Abdominal Adipose Tissue Losses nor Reduce Adipocyte Size or Inflammatory Markers in Overweight and Obese Adults: A Controlled Feeding Study , 2011, Journal of obesity.

[8]  V. Flood,et al.  Dairy consumption and overweight and obesity: a systematic review of prospective cohort studies , 2011, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[9]  M. Hedayati,et al.  Comparison of the effects of cows' milk, fortified soy milk, and calcium supplement on weight and fat loss in premenopausal overweight and obese women. , 2011, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[10]  M. Zemel,et al.  Dairy attentuates oxidative and inflammatory stress in metabolic syndrome123 , 2011, The American journal of clinical nutrition.

[11]  D. Mozaffarian,et al.  Changes in diet and lifestyle and long-term weight gain in women and men. , 2011, The New England journal of medicine.

[12]  M. Tarnopolsky,et al.  Increased Consumption of Dairy Foods and Protein during Diet- and Exercise-Induced Weight Loss Promotes Fat Mass Loss and Lean Mass Gain in Overweight and Obese Premenopausal Women1234 , 2011, The Journal of nutrition.

[13]  E. Ernst,et al.  Efficacy of calcium supplementation for management of overweight and obesity: systematic review of randomized clinical trials. , 2011, Nutrition reviews.

[14]  L. Wideman,et al.  Effects of a dairy supplement and resistance training on lean mass and insulin-like growth factor in women. , 2011, International journal of sport nutrition and exercise metabolism.

[15]  C. Palacios,et al.  No effects of low and high consumption of dairy products and calcium supplements on body composition and serum lipids in Puerto Rican obese adults. , 2011, Nutrition.

[16]  K. Cianflone,et al.  Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial , 2010, British Journal of Nutrition.

[17]  L. Wideman,et al.  Effects of Calcium and Resistance Exercise on Body Composition in Overweight Premenopausal Women , 2010, Journal of the American College of Nutrition.

[18]  R. Mensink,et al.  Effects of low-fat dairy consumption on markers of low-grade systemic inflammation and endothelial function in overweight and obese subjects: an intervention study , 2010, British Journal of Nutrition.

[19]  S. Pal,et al.  Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals , 2010, British Journal of Nutrition.

[20]  S. Mandrup,et al.  Antiobesity mechanisms of action of conjugated linoleic acid. , 2010, The Journal of nutritional biochemistry.

[21]  Leena Choi,et al.  Effect of Dairy and Nondairy Calcium on Fecal Fat Excretion in Lactose Digester and Maldigester Obese Adults , 2009, International Journal of Obesity.

[22]  P. Mutanen,et al.  Dairy products and metabolic effects in overweight men and women: results from a 6-mo intervention study. , 2009, The American journal of clinical nutrition.

[23]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement , 2009, BMJ.

[24]  A. Astrup,et al.  Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta‐analysis of randomized controlled trials , 2009, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[25]  J. Yanovski,et al.  Effects of Calcium Supplementation on Body Weight and Adiposity in Overweight and Obese Adults , 2009, Annals of Internal Medicine.

[26]  Y. Manios,et al.  Changes in body composition following a dietary and lifestyle intervention trial: the postmenopausal health study. , 2009, Maturitas.

[27]  D. Schoeller,et al.  Dairy-Rich Diets Augment Fat Loss on an Energy-Restricted Diet: A Multicenter Trial , 2009, Nutrients.

[28]  J. Salmon,et al.  Effects of a multi-component exercise program and calcium–vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial , 2009, Osteoporosis International.

[29]  R. DiSilvestro,et al.  Effects of Various Forms of Calcium on Body Weight and Bone Turnover Markers in Women Participating in a Weight Loss Program , 2007, Journal of the American College of Nutrition.

[30]  Parvez Hossain,et al.  Obesity and diabetes in the developing world--a growing challenge. , 2007, The New England journal of medicine.

[31]  G. McCabe,et al.  Fat oxidation and its relation to serum parathyroid hormone in young women enrolled in a 1-y dairy calcium intervention. , 2005, The American journal of clinical nutrition.

[32]  M. Zemel The Role of Dairy Foods in Weight Management , 2005, Journal of the American College of Nutrition.

[33]  J. Harvey-Berino,et al.  The impact of calcium and dairy product consumption on weight loss. , 2005, Obesity research.

[34]  M. Zemel,et al.  Effect of energy-reduced diets high in dairy products and fiber on weight loss in obese adults. , 2005, Obesity research.

[35]  M. Noakes,et al.  Effect of calcium and dairy foods in high protein, energy-restricted diets on weight loss and metabolic parameters in overweight adults , 2005, International Journal of Obesity.

[36]  M. Zemel,et al.  Effects of calcium and dairy on body composition and weight loss in African-American adults. , 2005, Obesity research.

[37]  G. McCabe,et al.  Dairy products do not lead to alterations in body weight or fat mass in young women in a 1-y intervention. , 2005, The American journal of clinical nutrition.

[38]  M. Zemel,et al.  Dairy augmentation of total and central fat loss in obese subjects , 2005, International Journal of Obesity.

[39]  P. Hamet,et al.  The influence of dairy products on plasma uric acid in women , 1995, European Journal of Epidemiology.

[40]  M. Zemel,et al.  Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. , 2004, Obesity research.

[41]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[42]  S. Chan,et al.  The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia , 2003, Osteoporosis International.

[43]  S. Barr Increased dairy product or calcium intake: is body weight or composition affected in humans? , 2003, The Journal of nutrition.

[44]  Theo Stijnen,et al.  Advanced methods in meta‐analysis: multivariate approach and meta‐regression , 2002, Statistics in medicine.

[45]  J. Woo,et al.  Milk Supplementation of the Diet of Postmenopausal Chinese Women on a Low Calcium Intake Retards Bone Loss , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[46]  S. Oparil,et al.  Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk factors in healthy older adults. , 2000, Journal of the American Dietetic Association.

[47]  P. Koskinen,et al.  Angiotensin I-converting enzyme inhibitory properties of whey protein digests: concentration and characterization of active peptides. , 2000, The Journal of dairy research.

[48]  C. Summerbell,et al.  Randomised controlled trial of novel, simple, and well supervised weight reducing diets in outpatients , 1998, BMJ.

[49]  A R Jadad,et al.  Assessing the quality of reports of randomized clinical trials: is blinding necessary? , 1996, Controlled clinical trials.

[50]  R. Lew,et al.  Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. , 1990, The Journal of clinical endocrinology and metabolism.