Spying on cancer: molecular imaging in vivo with genetically encoded reporters.

[1]  Michel Bouvier,et al.  Real-time monitoring of ubiquitination in living cells by BRET , 2004, Nature Methods.

[2]  Meng Yang,et al.  Transgenic Nude Mouse with Ubiquitous Green Fluorescent Protein Expression as a Host for Human Tumors , 2004, Cancer Research.

[3]  R. Tsien,et al.  Evolution of new nonantibody proteins via iterative somatic hypermutation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[4]  R. Tsien,et al.  Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein , 2004, Nature Biotechnology.

[5]  E. Holland,et al.  Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model , 2004, Nature Medicine.

[6]  J. Toppari,et al.  Indirect Sertoli Cell-Mediated Ablation of Germ Cells in Mice Expressing the Inhibin-α Promoter/Herpes Simplex Virus Thymidine Kinase Transgene1 , 2004, Biology of reproduction.

[7]  Haruo Kasai,et al.  Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC‐GFP transgenic mice , 2004 .

[8]  T. Möröy,et al.  Gfi1:Green Fluorescent Protein Knock-in Mutant Reveals Differential Expression and Autoregulation of the Growth Factor Independence 1 (Gfi1) Gene during Lymphocyte Development* , 2004, Journal of Biological Chemistry.

[9]  J. Haug,et al.  Kinetics of In Vivo Elimination of Suicide Gene-Expressing T Cells Affects Engraftment, Graft-versus-Host Disease, and Graft-versus-Leukemia after Allogeneic Bone Marrow Transplantation1 , 2004, The Journal of Immunology.

[10]  Lingyun Zhu,et al.  Non-invasive imaging of GFAP expression after neuronal damage in mice , 2004, Neuroscience Letters.

[11]  Vladimir Ponomarev,et al.  Molecular Imaging of Temporal Dynamics and Spatial Heterogeneity of Hypoxia-Inducible Factor-1 Signal Transduction Activity in Tumors in Living Mice , 2004, Cancer Research.

[12]  H. Piwnica-Worms,et al.  Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Y. Umezawa,et al.  High-throughput sensing and noninvasive imaging of protein nuclear transport by using reconstitution of split Renilla luciferase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Gambhir,et al.  Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors. , 2004, Human gene therapy.

[15]  A. McEwan,et al.  Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells. , 2004, Nuclear medicine and biology.

[16]  S. Gambhir,et al.  Molecular imaging of gene expression in living subjects by spliceosome-mediated RNA trans-splicing. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Peter Lassota,et al.  Bioluminescent imaging of Cdk2 inhibition in vivo , 2004, Nature Medicine.

[18]  G. Sundaresan,et al.  MicroPET imaging of Cre–loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene , 2004, Gene Therapy.

[19]  Sanjiv S. Gambhir,et al.  Molecular Imaging of Drug-Modulated Protein-Protein Interactions in Living Subjects , 2004, Cancer Research.

[20]  D. Piwnica-Worms,et al.  Technoreview: Molecular imaging of host–pathogen interactions in intact small animals , 2004, Cellular microbiology.

[21]  R. Tsien,et al.  Imaging Tri-Fusion Multimodality Reporter Gene Expression in Living Subjects , 2004, Cancer Research.

[22]  Julie L Prior,et al.  Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Christopher H Contag,et al.  Extracellular Replication of Listeria monocytogenes in the Murine Gall Bladder , 2004, Science.

[24]  Anton Berns,et al.  The generation of a conditional reporter that enables bioluminescence imaging of Cre/loxP-dependent tumorigenesis in mice. , 2003, Cancer research.

[25]  W. Webb,et al.  Nonlinear magic: multiphoton microscopy in the biosciences , 2003, Nature Biotechnology.

[26]  Harvey R Herschman,et al.  Molecular Imaging: Looking at Problems, Seeing Solutions , 2003, Science.

[27]  Andrew L Kung,et al.  Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. , 2003, Molecular imaging.

[28]  Kevin C. Chen,et al.  A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[29]  Mary E. Dickinson,et al.  Technicolour transgenics: imaging tools for functional genomics in the mouse , 2003, Nature Reviews Genetics.

[30]  K. Lindsten,et al.  A transgenic mouse model of the ubiquitin/proteasome system , 2003, Nature Biotechnology.

[31]  Jiling Song,et al.  Imaging 26S proteasome activity and inhibition in living mice , 2003, Nature Medicine.

[32]  S. Bouillot,et al.  Expression of thymidine kinase driven by an endothelial-specific promoter inhibits tumor growth of Lewis lung carcinoma cells in transgenic mice , 2003, Gene Therapy.

[33]  Ronald G Blasberg,et al.  Molecular-genetic imaging: current and future perspectives. , 2003, The Journal of clinical investigation.

[34]  Wei Li,et al.  Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo. , 2003, Cancer research.

[35]  R. Blasberg,et al.  Development of a new reporter gene system--dsRed/xanthine phosphoribosyltransferase-xanthine for molecular imaging of processes behind the intact blood-brain barrier. , 2003, Molecular imaging.

[36]  Michel Sadelain,et al.  Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes , 2003, Nature Biotechnology.

[37]  R. Blasberg,et al.  In vivo imaging of molecular-genetic targets for cancer therapy. , 2003, Cancer cell.

[38]  S. Larson,et al.  Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[39]  S. Gambhir,et al.  Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice. , 2003, Cancer research.

[40]  S S Gambhir,et al.  Monitoring protein-protein interactions using split synthetic renilla luciferase protein-fragment-assisted complementation. , 2003, Analytical chemistry.

[41]  S. Gambhir,et al.  Molecular imaging in living subjects: seeing fundamental biological processes in a new light. , 2003, Genes & development.

[42]  Yoram Zilberman,et al.  Molecular Imaging of the Skeleton: Quantitative Real‐Time Bioluminescence Monitoring Gene Expression in Bone Repair and Development , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  W. Heiss,et al.  Improved herpes simplex virus type 1 amplicon vectors for proportional coexpression of positron emission tomography marker and therapeutic genes. , 2003, Human gene therapy.

[44]  R. Weissleder,et al.  Molecular imaging in drug discovery and development , 2003, Nature Reviews Drug Discovery.

[45]  R. Weissleder,et al.  Optical-based molecular imaging: contrast agents and potential medical applications , 2003, European Radiology.

[46]  K. Svoboda,et al.  Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex , 2002, Nature.

[47]  Thomas L. Chenevert,et al.  Noninvasive real-time imaging of apoptosis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[48]  M E Dickinson,et al.  Dynamic in vivo imaging of postimplantation mammalian embryos using whole embryo culture , 2002, Genesis.

[49]  Gary D. Luker,et al.  Noninvasive Bioluminescence Imaging of Herpes Simplex Virus Type 1 Infection and Therapy in Living Mice , 2002, Journal of Virology.

[50]  S S Gambhir,et al.  Noninvasive imaging of protein–protein interactions in living subjects by using reporter protein complementation and reconstitution strategies , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[51]  C. Contag,et al.  It's not just about anatomy: In vivo bioluminescence imaging as an eyepiece into biology , 2002, Journal of magnetic resonance imaging : JMRI.

[52]  Gary D Luker,et al.  Molecular imaging of gene expression and protein function in vivo with PET and SPECT , 2002, Journal of magnetic resonance imaging : JMRI.

[53]  N. Lemoine,et al.  Adenovirus biodistribution and noninvasive imaging of gene expression in vivo by positron emission tomography using human sodium/iodide symporter as reporter gene. , 2002, Human gene therapy.

[54]  Hui Zhao,et al.  Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1 , 2002, Journal of Molecular Medicine.

[55]  J. Barrio,et al.  Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[56]  R. Weissleder,et al.  Fluorescence molecular tomography resolves protease activity in vivo , 2002, Nature Medicine.

[57]  R. Tsien,et al.  A monomeric red fluorescent protein , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Wei Li,et al.  Noninvasive imaging of protein–protein interactions in living animals , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[59]  Jos Jonkers,et al.  Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. , 2002, Cancer research.

[60]  S. Larson,et al.  Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[61]  Sanjiv S Gambhir,et al.  Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancer. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[62]  S S Gambhir,et al.  Noninvasive quantitative imaging of protein–protein interactions in living subjects , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[63]  H. Carlsen,et al.  In Vivo Imaging of NF-κB Activity1 , 2002, The Journal of Immunology.

[64]  Erik D Herzog,et al.  Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[65]  S. Gambhir,et al.  Optical imaging of Renilla luciferase reporter gene expression in living mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[66]  R. Weissleder,et al.  Human transferrin receptor gene as a marker gene for MR imaging. , 2001, Radiology.

[67]  C. Contag,et al.  Adoptive Immunotherapy of Experimental Autoimmune Encephalomyelitis Via T Cell Delivery of the IL-12 p40 Subunit1 , 2001, The Journal of Immunology.

[68]  Xiaoen Wang,et al.  Spatial–temporal imaging of bacterial infection and antibiotic response in intact animals , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[69]  J Humm,et al.  Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[70]  S. Larson,et al.  Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer , 2001, Nature Medicine.

[71]  Ralph Weissleder,et al.  In vivo molecular target assessment of matrix metalloproteinase inhibition , 2001, Nature Medicine.

[72]  S. Larson,et al.  Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. , 2001, Cancer research.

[73]  Eric C. Holland,et al.  Gliomagenesis: genetic alterations and mouse models , 2001, Nature Reviews Genetics.

[74]  S. Rodems,et al.  A ubiquitin-based tagging system for controlled modulation of protein stability , 2000, Nature Biotechnology.

[75]  G. Feng,et al.  Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP , 2000, Neuron.

[76]  K. Zinn,et al.  Gene transfer strategies for improving radiolabeled peptide imaging and therapy. , 2000, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

[77]  M. Yamaguchi,et al.  Visualization of neurogenesis in the central nervous system using nestin promoter‐GFP transgenic mice , 2000, Neuroreport.

[78]  H. Schöler,et al.  The onset of germ cell migration in the mouse embryo , 2000, Mechanisms of Development.

[79]  Scott E. Fraser,et al.  In vivo visualization of gene expression using magnetic resonance imaging , 2000, Nature Biotechnology.

[80]  Anna Moore,et al.  In vivo magnetic resonance imaging of transgene expression , 2000, Nature Medicine.

[81]  R. Blasberg,et al.  Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. , 1999, Cancer research.

[82]  R G Blasberg,et al.  Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[83]  M. Tarpey,et al.  Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation. , 1999, Circulation research.

[84]  R. Weissleder,et al.  In vivo imaging of tumors with protease-activated near-infrared fluorescent probes , 1999, Nature Biotechnology.

[85]  R. Xavier,et al.  Tumor Induction of VEGF Promoter Activity in Stromal Cells , 1998, Cell.

[86]  Masafumi Oshiro,et al.  Visualizing Gene Expression in Living Mammals Using a Bioluminescent Reporter , 1997, Photochemistry and photobiology.

[87]  Weiya Ma,et al.  Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[88]  A. Varshavsky,et al.  Ubiquitin as a degradation signal. , 1992, The EMBO journal.

[89]  D. Piwnica-Worms,et al.  Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters. , 2005, Methods in enzymology.

[90]  B. Ross,et al.  Bioluminescence detection of cells having stabilized p53 in response to a genotoxic event. , 2004, Molecular imaging.

[91]  Kathryn E Luker,et al.  Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals. , 2004, Methods in enzymology.

[92]  Vasilis Ntziachristos,et al.  Shedding light onto live molecular targets , 2003, Nature Medicine.

[93]  A. Maggi,et al.  In vivo imaging of transcriptionally active estrogen receptors , 2003, Nature Medicine.

[94]  R. Weissleder Scaling down imaging: molecular mapping of cancer in mice , 2002, Nature Reviews Cancer.

[95]  C. Contag,et al.  Advances in in vivo bioluminescence imaging of gene expression. , 2002, Annual review of biomedical engineering.

[96]  T. Akhurst,et al.  Tumor-specific transcriptional targeting of suicide gene therapy , 2002, Gene Therapy.

[97]  Daniel E. Hall,et al.  Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. , 2000, Neoplasia.

[98]  V. D’Agati,et al.  Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis. , 1999, Developmental genetics.