The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain
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Joachim Herz | Daniela Hartl | Guido Mastrobuoni | Stefan Kempa | S. Kempa | T. Willnow | J. Heeren | J. Herz | G. Mastrobuoni | Joerg Heeren | A. Nykjaer | M. Nielsen | C. Petersen | C. Gustafsen | Thomas E Willnow | D. Hartl | Anne-Sophie Carlo | Camilla Gustafsen | Morten S Nielsen | Tilman Burgert | Michael Rohe | Anders Nykjaer | Claus Munck Petersen | A. Carlo | Michael Rohe | Tilman Burgert | Camilla Gustafsen
[1] D. Holtzman,et al. The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice* , 2005, Journal of Biological Chemistry.
[2] Matthew P. Frosch,et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[3] J. Herz,et al. ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling , 2010, Proceedings of the National Academy of Sciences.
[4] M. Pericak-Vance,et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[5] Donald A. Wilson,et al. ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models , 2012, Science.
[6] B. Hyman,et al. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. , 2000, The Journal of biological chemistry.
[7] A. Fagan,et al. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. , 1999, The Journal of clinical investigation.
[8] M. Kaghad,et al. The 100-kDa Neurotensin Receptor Is gp95/Sortilin, A Non-G-Protein-coupled Receptor* , 1998, The Journal of Biological Chemistry.
[9] S. Paul,et al. Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression , 2009, The Journal of Neuroscience.
[10] E. Rubin,et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.
[11] S. Paul,et al. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.
[12] J. Heeren,et al. Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells. , 2008, Biochimica et biophysica acta.
[13] C McRae,et al. Myocardial infarction. , 2019, Australian family physician.
[14] D. Holtzman,et al. Apolipoprotein E and Low Density Lipoprotein Receptor-related Protein Facilitate Intraneuronal Aβ42 Accumulation in Amyloid Model Mice* , 2006, Journal of Biological Chemistry.
[15] R. Mahley,et al. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. , 1987, Biochimica et biophysica acta.
[16] P. Nissen,et al. Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain , 2009, Nature Structural &Molecular Biology.
[17] C. Göritz,et al. CNS synaptogenesis promoted by glia-derived cholesterol. , 2001, Science.
[18] Kaj Blennow,et al. Measurement of Apolipoprotein E (apoE) in Cerebrospinal Fluid , 2000, Neurochemical Research.
[19] N. Tommerup,et al. Molecular Identification of a Novel Candidate Sorting Receptor Purified from Human Brain by Receptor-associated Protein Affinity Chromatography* , 1997, The Journal of Biological Chemistry.
[20] Guojun Bu,et al. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.
[21] Alberto Piazza,et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants , 2009, Nature Genetics.
[22] A. Sporbert,et al. SorLA/LR11 Regulates Processing of Amyloid Precursor Protein via Interaction with Adaptors GGA and PACS-1* , 2007, Journal of Biological Chemistry.
[23] Sascha Weggen,et al. The cytoplasmic domain of the LDL receptor‐related protein regulates multiple steps in APP processing , 2002, The EMBO journal.
[24] E. Cooper. Neuron-specific enolase. , 1994, The International journal of biological markers.
[25] T. Saido,et al. Metabolic Regulation of Brain Aβ by Neprilysin , 2001, Science.
[26] D. Holtzman,et al. Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance , 2009, Neuron.
[27] D. Holtzman,et al. ApoE Promotes the Proteolytic Degradation of Aβ , 2008, Neuron.
[28] J. Nyengaard,et al. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury , 2007, Nature Neuroscience.
[29] R. Mahley,et al. Astroglial Regulation of Apolipoprotein E Expression in Neuronal Cells , 2004, Journal of Biological Chemistry.
[30] R. Hammer,et al. Sustained somatic gene inactivation by viral transfer of Cre recombinase , 1996, Nature Biotechnology.
[31] Barbara L. Hempstead,et al. Sortilin is essential for proNGF-induced neuronal cell death , 2004, Nature.
[32] A. Fagan,et al. Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta. , 2005, Neurobiology of disease.
[33] T. Willnow,et al. Sortilin: a receptor to regulate neuronal viability and function , 2012, Trends in Neurosciences.
[34] H. Feldman,et al. Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin , 2010, Neuron.
[35] M. Ohno,et al. Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation , 2006, The Journal of Neuroscience.
[36] J. Wuu,et al. Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease , 2010, Neuroscience Letters.
[37] L. Mucke,et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein , 1995, Nature.
[38] Rudolph E Tanzi,et al. Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex , 2010, The Journal of Neuroscience.
[39] G. Lienhard,et al. Sortilin Is the Major 110-kDa Protein in GLUT4 Vesicles from Adipocytes* , 1998, The Journal of Biological Chemistry.
[40] A. Fagan,et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[41] L. Muglia,et al. Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1 , 2007, Neuron.
[42] Xianlin Han,et al. Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease , 2010, Neurobiology of Aging.
[43] Xianlin Han,et al. Novel Role for Apolipoprotein E in the Central Nervous System , 2003, The Journal of Biological Chemistry.
[44] B. Hyman,et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[45] D. Selkoe,et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[46] Xianlin Han,et al. Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration , 2010, The Journal of Neuroscience.
[47] J. Haines,et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.
[48] R. Mahley,et al. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[49] Olle Melander,et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus , 2010, Nature.
[50] P. Madsen,et al. The sortilin cytoplasmic tail conveys Golgi–endosome transport and binds the VHS domain of the GGA2 sorting protein , 2001, The EMBO journal.
[51] P. Madsen,et al. Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. , 2010, Cell metabolism.
[52] R. Prediger,et al. Folic acid plus α-tocopherol mitigates amyloid-β-induced neurotoxicity through modulation of mitochondrial complexes activity. , 2011, Journal of Alzheimer's disease : JAD.
[53] H. Okada,et al. BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin* , 2011, The Journal of Biological Chemistry.
[54] B. Michalski,et al. The Precursor Pro-Nerve Growth Factor Is the Predominant Form of Nerve Growth Factor in Brain and Is Increased in Alzheimer's Disease , 2001, Molecular and Cellular Neuroscience.
[55] Peter J. Lenting,et al. LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms , 2004, Neuron.
[56] A. Beaudet,et al. Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system , 2003, The Journal of comparative neurology.
[57] J. Heeren,et al. Intracellular processing of endocytosed triglyceride-rich lipoproteins comprises both recycling and degradation. , 1999, Journal of cell science.
[58] Tim West,et al. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis , 2012, Proceedings of the National Academy of Sciences.
[59] Edwin J. Weeber,et al. Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice , 2004, Molecular and Cellular Biology.
[60] S. Paul,et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. , 1997, Nature genetics.
[61] S. Baker,et al. Neuron‐specific enolase‐cre mouse line with cre activity in specific neuronal populations , 2006, Genesis.
[62] C. Buhmann,et al. Characterization of four lipoprotein classes in human cerebrospinal fluid. , 2001, Journal of lipid research.
[63] Barbara L. Hempstead,et al. ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin , 2005, The Journal of Neuroscience.
[64] B. Hyman,et al. The Intracellular Domain of the Low Density Lipoprotein Receptor-related Protein Modulates Transactivation Mediated by Amyloid Precursor Protein and Fe65* , 2003, Journal of Biological Chemistry.
[65] A. Kurz,et al. Amyloid clearance as a treatment target against Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.
[66] David M Holtzman,et al. Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance , 2011, Science Translational Medicine.