Whey protein hydrolysate mitigates both inflammation and endotoxin tolerance in THP‐1 human monocytic leukemia cells

It is important to control both inflammation and immunosuppression after severe insults, such as sepsis, trauma, and surgery. Endotoxin tolerance is one of the immunosuppressive conditions and it has been known that endotoxin tolerance relates to poorer clinical outcomes in patients with severe insults. This study investigated whether whey protein hydrolysate (WPH) mitigates inflammation and endotoxin tolerance in THP‐1 human monocytic leukemia cells.

[1]  Scott R. Presnell,et al.  Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness , 2022, American journal of physiology. Lung cellular and molecular physiology.

[2]  Terri A Meehan-Andrews,et al.  A systematic review and meta-analyses of interleukin-1 receptor associated kinase 3 (IRAK3) action on inflammation in in vivo models for the study of sepsis , 2022, PloS one.

[3]  T. J. Ashaolu,et al.  Whey proteins and peptides in health-promoting functions – A review , 2021, International Dairy Journal.

[4]  H. Simon,et al.  Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function , 2021, Nutrients.

[5]  Min Ji Lee,et al.  The Need of Enterococcal Coverage in Severe Intra-Abdominal Infection: Evidence from Animal Study , 2021, Journal of clinical medicine.

[6]  H. Irving,et al.  Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis , 2020, PloS one.

[7]  Z. Meng,et al.  Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art , 2020, Frontiers in Immunology.

[8]  R. Hotchkiss,et al.  Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections , 2020, JCI insight.

[9]  A. Hoeft,et al.  Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells , 2020, Mediators of inflammation.

[10]  Petra C. Kienesberger,et al.  Whey Peptides Stimulate Differentiation and Lipid Metabolism in Adipocytes and Ameliorate Lipotoxicity-Induced Insulin Resistance in Muscle Cells , 2020, Nutrients.

[11]  B. Relja,et al.  Cytokines in Inflammatory Disease , 2019, International journal of molecular sciences.

[12]  N. Nesseler,et al.  Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis: A prospective observational study. , 2019, Anaesthesia, critical care & pain medicine.

[13]  Yuxia Xiong,et al.  Recent advances in endotoxin tolerance , 2018, Journal of cellular biochemistry.

[14]  C. Rossetti,et al.  MiR-146a induction by cyanobacterial lipopolysaccharide antagonist (CyP) mediates endotoxin cross-tolerance , 2018, Scientific Reports.

[15]  A. González-Córdova,et al.  Milk Fermented by Specific Lactobacillus Strains Regulates the Serum Levels of IL-6, TNF-α and IL-10 Cytokines in a LPS-Stimulated Murine Model , 2018, Nutrients.

[16]  F. Venet,et al.  Advances in the understanding and treatment of sepsis-induced immunosuppression , 2018, Nature Reviews Nephrology.

[17]  P. de Vos,et al.  Toll-like receptor mediated activation is possibly involved in immunoregulating properties of cow's milk hydrolysates , 2017, PloS one.

[18]  R. Guthke,et al.  Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFα expression , 2017, Scientific Reports.

[19]  L. Yu,et al.  Isolation and characterization of anti-inflammatory peptides derived from whey protein. , 2016, Journal of dairy science.

[20]  E. Rios,et al.  The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide. , 2016, Life sciences.

[21]  T. Yamaji,et al.  Protective effect of an immune-modulating diet comprising whey peptides and fermented milk products on indomethacin-induced small-bowel disorders in rats. , 2014, Clinical nutrition.

[22]  G. Besner,et al.  Innate Immune Function Predicts the Development of Nosocomial Infection in Critically Injured Children , 2014, Shock.

[23]  Y. Kimura,et al.  Whey peptides prevent chronic ultraviolet B radiation-induced skin aging in melanin-possessing male hairless mice. , 2014, The Journal of nutrition.

[24]  R. Hotchkiss,et al.  Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy , 2013, Nature Reviews Immunology.

[25]  C. del Fresno,et al.  Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences , 2013, Critical Care.

[26]  F. Malcata,et al.  Antinociceptive and anti-inflammatory effects of novel dietary protein hydrolysate produced from whey by proteases of Cynara cardunculus , 2013 .

[27]  M. Netea,et al.  Pre-treatment with low-dose endotoxin prolongs survival from experimental lethal endotoxic shock: Benefit for lethal peritonitis by Escherichia coli. , 2013, Cytokine.

[28]  E. Rossmanith,et al.  Monocytes, Peripheral Blood Mononuclear Cells, and THP-1 Cells Exhibit Different Cytokine Expression Patterns following Stimulation with Lipopolysaccharide , 2013, Mediators of inflammation.

[29]  R. Hotchkiss,et al.  Immunosuppression in patients who die of sepsis and multiple organ failure. , 2011, JAMA.

[30]  C. Natanson,et al.  The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death , 2011, Expert opinion on investigational drugs.

[31]  M. Bauer,et al.  The late phase of sepsis is characterized by an increased microbiological burden and death rate , 2011, Critical care.

[32]  Olga M. Pena,et al.  Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells , 2011, The Journal of Immunology.

[33]  C. McCall,et al.  NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance* , 2011, The Journal of Biological Chemistry.

[34]  J. G. van der Hoeven,et al.  Development of endotoxin tolerance in humans in vivo , 2009, Critical care medicine.

[35]  K. Kawanaka,et al.  Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake rate in L6 myotubes and isolated skeletal muscles. , 2009, Journal of nutritional science and vitaminology.

[36]  E. Roth,et al.  Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients. , 2006, Shock.

[37]  J. Tabibian,et al.  Development of an in vitro screening assay to test the antiinflammatory properties of dietary supplements and pharmacologic agents. , 2005, Clinical chemistry.

[38]  Gifford Jl,et al.  Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. , 2005 .

[39]  S. Moochhala,et al.  Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome , 2004, The Journal of pathology.

[40]  M. West,et al.  Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients. , 2003, Surgical infections.

[41]  A. Cross.  Endotoxin tolerance-current concepts in historical perspective. , 2002, Journal of endotoxin research.

[42]  H. Volk,et al.  Impaired antigen presentation by human monocytes during endotoxin tolerance , 2000 .

[43]  C. Gogos,et al.  Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. , 2000, The Journal of infectious diseases.

[44]  J. Mege,et al.  Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. , 1997, Critical care medicine.

[45]  K. Rajewsky,et al.  Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. , 1995, The Journal of clinical investigation.

[46]  C. Meisel,et al.  Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta , 1995, The Journal of experimental medicine.

[47]  J. Cavaillon,et al.  Endotoxin tolerance is not a LPS-specific phenomenon: partial mimicry with IL-1, IL-10 and TGFβ , 1994 .

[48]  C. Galanos,et al.  Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages , 1988, Infection and immunity.