Research on peripheral nerve conduction block by high frequency alternating current stimulation

The purpose of this study was to demonstrate completely motor nerve conduction block can be obtained in peripheral nerve by using high frequency electrical stimulation; then investigate the frequency-threshold relationship of the high frequency alternating current (HFAC) blocking signal; and analyze the influence of high frequency signals on the muscles which dominated by the corresponding nerves. The results showed that the complete block could be achieved in certain frequencies and different muscle stiffness actions can be induced due to the different block frequency stimulation.

[1]  Kevin L Kilgore,et al.  Conduction block of peripheral nerve using high‐frequency alternating currents delivered through an intrafascicular electrode , 2010, Muscle & nerve.

[2]  Brian J. Andrews,et al.  Localized electrical nerve blocking , 1996, Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[3]  M M Elhilali,et al.  Reduction of bladder outlet resistance by selective stimulation of the ventral sacral root using high frequency blockade: a chronic study in spinal cord transected dogs. , 2001, The Journal of urology.

[4]  Changfeng Tai,et al.  Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve. , 2004, The Journal of urology.

[5]  G. Brindley,et al.  The first 500 patients with sacral anterior root stimulator implants: general description , 1994, Paraplegia.

[6]  Jeffrey C. Petruska,et al.  Anodally focused polarization of peripheral nerve allows discrimination of myelinated and unmyelinated fiber input to brainstem nuclei , 1998, Experimental Brain Research.

[7]  M Y WOO,et al.  ASYNCHRONOUS FIRING AND BLOCK OF PERIPHERAL NERVE CONDUCTION BY 20 KC ALTERNATING CURRENT. , 1964, Bulletin of the Los Angeles Neurological Society.

[8]  Warren M Grill,et al.  Analysis of the quasi-static approximation for calculating potentials generated by neural stimulation , 2008, Journal of neural engineering.

[9]  C. Tai,et al.  Animal study on selective stimulation of nerve fibers using biphasic rectangular pulses , 1998, Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286).

[10]  Gao Xin-ya.  Blocking effect of high frequency alternating current signal to nerve action potential conduction , 2011 .

[11]  Kevin L Kilgore,et al.  Frequency- and amplitude-transitioned waveforms mitigate the onset response in high-frequency nerve block , 2010, Journal of neural engineering.

[12]  M. Solomonow,et al.  Orderly stimulation of skeletal muscle motor units with tripolar nerve cuff electrode , 1989, IEEE Transactions on Biomedical Engineering.

[13]  Niloy Bhadra,et al.  High‐frequency electrical conduction block of mammalian peripheral motor nerve , 2005, Muscle & nerve.

[14]  E Eldred,et al.  Control of muscle contractile force through indirect high-frequency stimulation. , 1983, American journal of physical medicine.

[15]  J. A. TANNER,et al.  Reversible Blocking of Nerve Conduction by Alternating-Current Excitation , 1962, Nature.

[16]  Chou-Ching K. Lin,et al.  High frequency block of selected axons using an implantable microstimulator , 2004, Journal of Neuroscience Methods.

[17]  Changfeng Tai,et al.  Selective stimulation of smaller fibers in a compound nerve trunk with single cathode by rectangular current pulses , 1994, IEEE Transactions on Biomedical Engineering.

[18]  Brian J. Andrews,et al.  Localized electrical nerve blocking , 1996, IEEE Transactions on Biomedical Engineering.

[19]  J. S. Petrofsky,et al.  Control of the recruitment and firing frequencies of motor units in electrically stimulated muscles in the cat , 1978, Medical and Biological Engineering and Computing.

[20]  J. Mortimer,et al.  Selective activation of small motor axons by quasitrapezoidal current pulses , 1991, IEEE Transactions on Biomedical Engineering.